AutismKB 2.0

Annotation Detail for HSPG2


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Basic Information Top
Gene Symbol:HSPG2 ( PLC,PRCAN,SJA,SJS,SJS1 )
Gene Full Name: heparan sulfate proteoglycan 2
Band: 1p36.12
Quick LinksEntrez ID:3339; OMIM: 142461; Uniprot ID:PGBM_HUMAN; ENSEMBL ID: ENSG00000142798; HGNC ID: 5273
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
65O-linked (Xyl...) (heparan sulfate)
71O-linked (Xyl...) (heparan sulfate)
76O-linked (Xyl...) (heparan sulfate)
89N-linked (GlcNAc...) (Potential).
554N-linked (GlcNAc...).
1755N-linked (GlcNAc...).
2121N-linked (GlcNAc...).
2995O-linked (Xyl...) (chondroitin sulfate)
3072N-linked (GlcNAc...).
3105N-linked (GlcNAc...) (Potential).
3279N-linked (GlcNAc...) (Potential).
3780N-linked (GlcNAc...).
3836N-linked (GlcNAc...).
3933O-linked (Xyl...) (chondroitin sulfate)
4068N-linked (GlcNAc...).
4179O-linked (Xyl...) (chondroitin sulfate)
Location(AA) Modifications Resource
65O-linked (Xyl...) (heparan sulfate)(Potential).Swiss-Prot 53.0
71O-linked (Xyl...) (heparan sulfate)(Potential).Swiss-Prot 53.0
76O-linked (Xyl...) (heparan sulfate)(Potential).Swiss-Prot 53.0
89N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
554N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1755N-linked (GlcNAc...).Swiss-Prot 53.0
2121N-linked (GlcNAc...).Swiss-Prot 53.0
2995O-linked (Xyl...) (chondroitin sulfate)(Potential).Swiss-Prot 53.0
3072N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3105N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3279N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3780N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3836N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3933O-linked (Xyl...) (chondroitin sulfate)(Potential).Swiss-Prot 53.0
4068N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
4179O-linked (Xyl...) (chondroitin sulfate)(Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
54Phosphoserine(CK2)HMM predict
54Phosphoserine(CK2)HMM predict
54Phosphoserine(ATM)HMM predict
89N-linkedHMM predict
123Phosphotyrosine(Syk)HMM predict
176O-linkedHMM predict
242Phosphoserine(CDC2)HMM predict
260Phosphothreonine(PKA)HMM predict
269O-linkedHMM predict
392Phosphoserine(CK2)HMM predict
410Phosphothreonine(CDC2)HMM predict
410Phosphothreonine(MAPK)HMM predict
410Phosphothreonine(CDK)HMM predict
423Phosphothreonine(PKC)HMM predict
454O-linkedHMM predict
454Phosphothreonine(PKC)HMM predict
472Phosphoserine(CK2)HMM predict
477Phosphotyrosine(INSR)HMM predict
477Phosphotyrosine(Jak)HMM predict
554N-linkedHMM predict
563Phosphothreonine(MAPK)HMM predict
563Phosphothreonine(CDK)HMM predict
567O-linkedHMM predict
665Phosphoserine(CK1)HMM predict
704Phosphoserine(CAMK2)HMM predict
727Phosphoserine(IKK)HMM predict
764S-palmitoylHMM predict
935Phosphoserine(CK1)HMM predict
970Phosphoserine(CDC2)HMM predict
1017O-linkedHMM predict
1022Phosphothreonine(MAPK)HMM predict
1022Phosphothreonine(CDK)HMM predict
1048O-linkedHMM predict
1048Phosphoserine(IKK)HMM predict
1132Phosphotyrosine(Abl)HMM predict
1136Phosphoserine(PKB)HMM predict
1256N-linkedHMM predict
1396Phosphotyrosine(EGFR)HMM predict
1580Phosphoserine(ATM)HMM predict
1660N-linkedHMM predict
1744Phosphotyrosine(Jak)HMM predict
1755N-linkedHMM predict
1756Phosphothreonine(PKC)HMM predict
1768O-linkedHMM predict
1838Phosphotyrosine(Jak)HMM predict
1860O-linkedHMM predict
1862Phosphothreonine(PKC)HMM predict
1890O-linkedHMM predict
1892Phosphoserine(CDC2)HMM predict
1892Phosphoserine(IKK)HMM predict
1894Phosphothreonine(MAPK)HMM predict
1931Phosphotyrosine(Jak)HMM predict
1961Phosphoserine(CDC2)HMM predict
1972Phosphothreonine(PKC)HMM predict
2029Phosphoserine(CDC2)HMM predict
2057Phosphoserine(CK2)HMM predict
2058O-linkedHMM predict
2059Phosphoserine(CDK)HMM predict
2059Phosphoserine(ATM)HMM predict
2061O-linkedHMM predict
2061Phosphoserine(CK1)HMM predict
2061Phosphoserine(IKK)HMM predict
2090Phosphoserine(PKA)HMM predict
2090Phosphoserine(PKB)HMM predict
2115Phosphotyrosine(INSR)HMM predict
2115Phosphotyrosine(Jak)HMM predict
2121N-linkedHMM predict
2143O-linkedHMM predict
2145O-linkedHMM predict
2191Phosphoserine(PKA)HMM predict
2216Phosphotyrosine(EGFR)HMM predict
2216Phosphotyrosine(INSR)HMM predict
2216Phosphotyrosine(Jak)HMM predict
2251Phosphoserine(CK2)HMM predict
2252O-linkedHMM predict
2254Phosphoserine(CK1)HMM predict
2284Phosphoserine(PKA)HMM predict
2324O-linkedHMM predict
2326O-linkedHMM predict
2328O-linkedHMM predict
2350Phosphoserine(ATM)HMM predict
2380Phosphoserine(PKA)HMM predict
2398Phosphoserine(CAMK2)HMM predict
2405Phosphotyrosine(INSR)HMM predict
2405Phosphotyrosine(Jak)HMM predict
2423O-linkedHMM predict
2443Phosphoserine(PKA)HMM predict
2443Phosphoserine(CK1)HMM predict
2443Phosphoserine(CK2)HMM predict
2446Phosphoserine(CK1)HMM predict
2446Phosphoserine(ATM)HMM predict
2476Phosphoserine(PKA)HMM predict
2501Phosphotyrosine(INSR)HMM predict
2501Phosphotyrosine(Jak)HMM predict
2525Phosphoserine(CK1)HMM predict
2529Phosphoserine(ATM)HMM predict
2540Phosphoserine(CK2)HMM predict
2573Phosphoserine(PKA)HMM predict
2598Phosphotyrosine(EGFR)HMM predict
2598Phosphotyrosine(INSR)HMM predict
2598Phosphotyrosine(Jak)HMM predict
2623O-linkedHMM predict
2627O-linkedHMM predict
2669Phosphoserine(PKA)HMM predict
2694Phosphotyrosine(INSR)HMM predict
2694Phosphotyrosine(Jak)HMM predict
2719Phosphoserine(CDC2)HMM predict
2719Phosphoserine(IKK)HMM predict
2791Phosphotyrosine(INSR)HMM predict
2791Phosphotyrosine(Jak)HMM predict
2809O-linkedHMM predict
2891Phosphotyrosine(INSR)HMM predict
2891Phosphotyrosine(Jak)HMM predict
2896O-linkedHMM predict
2901Phosphothreonine(PKC)HMM predict
2909O-linkedHMM predict
2914O-linkedHMM predict
2914Phosphoserine(CDC2)HMM predict
2914Phosphoserine(CDK)HMM predict
2914Phosphoserine(ATM)HMM predict
2928Phosphotyrosine(Jak)HMM predict
2964Phosphoserine(PKA)HMM predict
2989Phosphotyrosine(INSR)HMM predict
2989Phosphotyrosine(Jak)HMM predict
3004O-linkedHMM predict
3008O-linkedHMM predict
3012O-linkedHMM predict
3015Phosphoserine(CK1)HMM predict
3021Phosphoserine(CDC2)HMM predict
3031O-linkedHMM predict
3032O-linkedHMM predict
3072N-linkedHMM predict
3105N-linkedHMM predict
3131Phosphothreonine(PKC)HMM predict
3151Phosphoserine(PKB)HMM predict
3161Phosphotyrosine(INSR)HMM predict
3161Phosphotyrosine(SRC)HMM predict
3183Phosphotyrosine(INSR)HMM predict
3230Phosphothreonine(PKA)HMM predict
3234O-linkedHMM predict
3236O-linkedHMM predict
3238O-linkedHMM predict
3238Phosphoserine(CDC2)HMM predict
3238Phosphoserine(IKK)HMM predict
3242Phosphothreonine(PKC)HMM predict
3276Phosphotyrosine(INSR)HMM predict
3279N-linkedHMM predict
3300Phosphotyrosine(Abl)HMM predict
3302O-linkedHMM predict
3302O-linkedHMM predict
3303O-linkedHMM predict
3325Phosphothreonine(CDK)HMM predict
3388O-linkedHMM predict
3392O-linkedHMM predict
3393O-linkedHMM predict
3393O-linkedHMM predict
3398O-linkedHMM predict
3399Phosphothreonine(MAPK)HMM predict
3405O-linkedHMM predict
3405Phosphothreonine(MAPK)HMM predict
3556O-linkedHMM predict
3558O-linkedHMM predict
3639Phosphotyrosine(Jak)HMM predict
3683Phosphotyrosine(EGFR)HMM predict
3683Phosphotyrosine(Jak)HMM predict
3696Phosphoserine(IKK)HMM predict
3712Phosphoserine(CDC2)HMM predict
3712Phosphoserine(IKK)HMM predict
3745Phosphothreonine(PKC)HMM predict
3780N-linkedHMM predict
3836N-linkedHMM predict
3864Phosphoserine(CK1)HMM predict
3912S-palmitoylHMM predict
3929O-linkedHMM predict
3929Phosphothreonine(CDK)HMM predict
3931O-linkedHMM predict
3931O-linkedHMM predict
4039Phosphoserine(CDC2)HMM predict
4039Phosphoserine(CDK)HMM predict
4064Phosphoserine(CDC2)HMM predict
4064Phosphoserine(IKK)HMM predict
4096Phosphoserine(ATM)HMM predict
4131S-palmitoylHMM predict
4166S-palmitoylHMM predict
4237Phosphoserine(PKG)HMM predict
4306Phosphoserine(PKG)HMM predict
4319Phosphoserine(CDC2)HMM predict
4333Phosphotyrosine(INSR)HMM predict
4386Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005529
  • Location:chr1 22021324-22136333
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF HelaGSE12889 22138758 22138931 173 2511
CTCF G2GSE9613 22136679 22136992 313 502
CTCF G2GSE9613 22138712 22139028 316 2537
CTCF G2GSE9613 22140250 22140394 144 3989
ER MCF7GSE19013 22155755 22156500 745 19794
Fos K562GSE19551 22141911 22142635 724 5940
H3K4me2 HCT116GSE10453 22136758 22137152 394 622
H3ac HepG2E 22136897 22137152 255 691
PAX3-FKHR Rh4GSE19063 22138461 22139546 1085 2670
RARA MCF7GSE15244 22155906 22156404 498 19822
TAF k562GSE8489 22136823 22137152 329 654
USF1 HepG2E 22140250 22141900 1650 4742
USF2 HepG2E 22140507 22141900 1393 4870
hScc1 BcellGSE12603 22136679 22137110 431 561
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 22060943 22061856 913 0
CBP T30-glioblastomaGSE21026 22129825 22130888 1063 0
CTCF G2GSE9613 22028074 22028779 705 0
CTCF G2GSE9613 22030105 22030465 360 0
CTCF G2GSE9613 22040116 22040406 290 0
CTCF G2GSE9613 22042149 22042481 332 0
CTCF G2GSE9613 22049078 22049447 369 0
CTCF G2GSE9613 22053359 22054819 1460 0
CTCF G2GSE9613 22058629 22058864 235 0
CTCF G2GSE9613 22064486 22064757 271 0
CTCF G2GSE9613 22069809 22070207 398 0
CTCF G2GSE9613 22071727 22072165 438 0
CTCF G2GSE9613 22074702 22075773 1071 0
CTCF G2GSE9613 22077750 22078224 474 0
CTCF G2GSE9613 22083969 22084352 383 0
CTCF G2GSE9613 22093065 22093472 407 0
CTCF G2GSE9613 22096403 22096640 237 0
CTCF G2GSE9613 22097970 22098265 295 0
CTCF G2GSE9613 22100532 22100947 415 0
CTCF G2GSE9613 22101230 22101411 181 0
CTCF G2GSE9613 22108208 22108782 574 0
CTCF G2GSE9613 22113824 22114155 331 0
CTCF G2GSE9613 22124602 22124813 211 0
CTCF G2GSE9613 22130397 22131084 687 0
CTCF G2GSE9613 22131627 22131837 210 0
CTCF G2GSE9613 22132328 22132554 226 0
CTCF G2GSE9613 22133010 22133366 356 0
FOXA1 MCF7GSE15244 22054893 22055453 560 0
Fos K562GSE19551 22118523 22119009 486 0
FoxA1 MCF7MACSdata 22055030 22055222 192 0
GABP k562GSE8489 22104108 22104477 369 0
Gata1 K562GSE18868 22103648 22104660 1012 0
Gata2 K562GSE18868 22103502 22104608 1106 0
Gata2 K562GSE18868 22115776 22116411 635 0
H3ac HepG2E 22110773 22111449 676 0
H3ac HepG2E 22122525 22122695 170 0
H3ac HepG2E 22123229 22124161 932 0
H3ac HepG2E 22128732 22129254 522 0
H3ac HepG2E 22130901 22131837 936 0
H3ac HepG2E 22132328 22132772 444 0
H3ac HepG2E 22133189 22133366 177 0
H3ac HepG2E 22134471 22135858 1387 0
NFkBII GM10847GSE19485 22108424 22109477 1053 0
Oct1 HelaGSE14283 22039407 22039452 45 0
Oct1 HelaGSE14283 22050518 22050552 34 0
Oct1 HelaGSE14283 22102303 22102342 39 0
Oct1 HelaGSE14283 22103553 22103584 31 0
P300 T0-glioblastomaGSE21026 22068784 22069301 517 0
P300 T30-glioblastomaGSE21026 22060947 22061814 867 0
P300 T30-glioblastomaGSE21026 22068639 22069475 836 0
P300 T30-glioblastomaGSE21026 22129586 22131043 1457 0
RARA MCF7GSE15244 22054922 22055312 390 0
TAF k562GSE8489 22107143 22107877 734 0
TFAP2C MCF7GSE21234 22052050 22052480 430 0
TFAP2C MCF7GSE21234 22054783 22055491 708 0
TFAP2C MCF7GSE21234 22068575 22069484 909 0
hScc1 BcellGSE12603 22040116 22040651 535 0
hScc1 BcellGSE12603 22049328 22049547 219 0
hScc1 BcellGSE12603 22053436 22053715 279 0
hScc1 BcellGSE12603 22054269 22054752 483 0
hScc1 BcellGSE12603 22058436 22058776 340 0
hScc1 BcellGSE12603 22059204 22059553 349 0
hScc1 BcellGSE12603 22062988 22064106 1118 0
hScc1 BcellGSE12603 22079381 22079875 494 0
hScc1 BcellGSE12603 22083530 22084821 1291 0
hScc1 BcellGSE12603 22086797 22087735 938 0
hScc1 BcellGSE12603 22100777 22101342 565 0
hScc1 BcellGSE12603 22105253 22105615 362 0
hScc1 BcellGSE12603 22108997 22109613 616 0
hScc1 BcellGSE12603 22110304 22110707 403 0
hScc1 BcellGSE12603 22130829 22131049 220 0
p130 QuiescentGSE19898 22130266 22130490 224 0
p130 shRbQuiescentGSE19898 22130282 22130811 529 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 20150764
hsa-miR-122* hsa-mir-122 18 20150764
hsa-miR-125a-5p hsa-mir-125a 19 21317190
hsa-miR-21 hsa-mir-21 17 20978511
hsa-miR-21* hsa-mir-21 17 20978511
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
351 mRNA LOC401944 chr1 21884063 21897020 1156 mRNA HSPG2 chr1 21894545 22009053Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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