AutismKB 2.0

Annotation Detail for FREM2


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Basic Information Top
Gene Symbol:FREM2 ( DKFZp686J0811,DKFZp781I048,KIAA1074 )
Gene Full Name: FRAS1 related extracellular matrix protein 2
Band: 13q13.3
Quick LinksEntrez ID:341640; OMIM: 608945; Uniprot ID:FREM2_HUMAN; ENSEMBL ID: ENSG00000150893; HGNC ID: 25396
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
358N-linked (GlcNAc...) (Potential).
1244N-linked (GlcNAc...) (Potential).
1369N-linked (GlcNAc...) (Potential).
1584N-linked (GlcNAc...) (Potential).
1741N-linked (GlcNAc...).
Location(AA) Modifications Resource
358N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1244N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1369N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1584N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1741N-linked (GlcNAc...).Swiss-Prot 53.0
Location(AA) Modification Resource
16N-linkedHMM predict
57Phosphoserine(MAPK)HMM predict
145Phosphoserine(CDC2)HMM predict
244MethylarginineHMM predict
358N-linkedHMM predict
369Phosphotyrosine(Jak)HMM predict
471Phosphoserine(CK2)HMM predict
502O-linkedHMM predict
508Phosphothreonine(PKC)HMM predict
527Phosphoserine(CK1)HMM predict
527Phosphoserine(IKK)HMM predict
636Phosphotyrosine(EGFR)HMM predict
662Phosphoserine(CDC2)HMM predict
662Phosphoserine(MAPK)HMM predict
682N-linkedHMM predict
719Phosphothreonine(MAPK)HMM predict
743O-linkedHMM predict
743O-linkedHMM predict
745Phosphoserine(IKK)HMM predict
749PhosphothreonineHMM predict
766N-linkedHMM predict
848Phosphoserine(CK1)HMM predict
1040Phosphoserine(CK1)HMM predict
1054O-linkedHMM predict
1097Phosphoserine(CK1)HMM predict
1117N-linkedHMM predict
1148Phosphotyrosine(Jak)HMM predict
1172N-linkedHMM predict
1230O-linkedHMM predict
1244N-linkedHMM predict
1265SulfotyrosineHMM predict
1270Phosphoserine(CK1)HMM predict
1303Phosphothreonine(MAPK)HMM predict
1358Phosphothreonine(PKA)HMM predict
1358Phosphothreonine(PKC)HMM predict
1369N-linkedHMM predict
1371Phosphothreonine(CK2)HMM predict
1409Phosphotyrosine(Jak)HMM predict
1451Phosphoserine(IKK)HMM predict
1494SulfotyrosineHMM predict
1584N-linkedHMM predict
1585N-linkedHMM predict
1611Phosphoserine(CK2)HMM predict
1615O-linkedHMM predict
1666Phosphothreonine(PKC)HMM predict
1691Phosphoserine(CK1)HMM predict
1716N-linkedHMM predict
1741N-linkedHMM predict
1778Phosphotyrosine(Jak)HMM predict
1778Phosphotyrosine(Syk)HMM predict
1892Phosphoserine(CK1)HMM predict
1892Phosphoserine(CK2)HMM predict
1911Phosphoserine(ATM)HMM predict
1911Phosphoserine(IKK)HMM predict
1928O-linkedHMM predict
1931O-linkedHMM predict
1941Phosphoserine(CK2)HMM predict
1971Phosphotyrosine(EGFR)HMM predict
1971Phosphotyrosine(INSR)HMM predict
1971Phosphotyrosine(Syk)HMM predict
2018Phosphoserine(CK1)HMM predict
2018Phosphoserine(CK2)HMM predict
2025Phosphotyrosine(INSR)HMM predict
2025Phosphotyrosine(Abl)HMM predict
2044Phosphothreonine(PKC)HMM predict
2061Phosphotyrosine(INSR)HMM predict
2119Phosphoserine(IKK)HMM predict
2121N-linkedHMM predict
2142Phosphoserine(ATM)HMM predict
2209Phosphotyrosine(Syk)HMM predict
2226Phosphoserine(CDC2)HMM predict
2236N-linkedHMM predict
2303Phosphotyrosine(INSR)HMM predict
2303Phosphotyrosine(Syk)HMM predict
2392Phosphoserine(PKG)HMM predict
2414Phosphotyrosine(Syk)HMM predict
2419Phosphoserine(IKK)HMM predict
2427N-linkedHMM predict
2448Phosphoserine(CDC2)HMM predict
2448Phosphoserine(CDK)HMM predict
2536Phosphotyrosine(INSR)HMM predict
2569Phosphoserine(CDC2)HMM predict
2569Phosphoserine(ATM)HMM predict
2569Phosphoserine(IKK)HMM predict
2623Phosphothreonine(PKC)HMM predict
2642Phosphotyrosine(Syk)HMM predict
2684Phosphoserine(CDC2)HMM predict
2762O-linkedHMM predict
2762Phosphoserine(IKK)HMM predict
2789Phosphotyrosine(SRC)HMM predict
2789Phosphotyrosine(Abl)HMM predict
2911Phosphotyrosine(EGFR)HMM predict
2926Phosphotyrosine(INSR)HMM predict
2926Phosphotyrosine(Jak)HMM predict
3039Phosphoserine(ATM)HMM predict
3046Phosphothreonine(PKC)HMM predict
3049Phosphoserine(PKC)HMM predict
3104Phosphoserine(CDC2)HMM predict
3104Phosphoserine(CDK)HMM predict
3140Phosphoserine(PKC)HMM predict
3152O-linkedHMM predict
3153O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_207361
  • Location:chr13 38159481-38352922
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 38156443 38157577 1134 2472
FOXA1 MCF7GSE15244 38158173 38159007 834 892
Oct1 HelaGSE14283 38151280 38151351 71 8166
RARA MCF7GSE15244 38156745 38157266 521 2476
RARA MCF7GSE15244 38157806 38158971 1165 1093
RARG MCF7GSE15244 38156885 38157234 349 2422
RARG MCF7GSE15244 38158136 38159007 871 910
TFAP2C MCF7GSE21234 38156816 38157285 469 2431
TFAP2C MCF7GSE21234 38158043 38159305 1262 808
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 38354011 38354068 57 1117
Oct1 HelaGSE14283 38353763 38353820 57 869
Stat6 IL-4-hr4GSE17850 38371338 38372118 780 18806
TFAP2C MCF7GSE21234 38360440 38360890 450 7743
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 38159534 38160497 963 0
CTCF G2GSE9613 38160779 38161099 320 0
CTCF G2GSE9613 38161971 38162223 252 0
CTCF G2GSE9613 38235865 38236248 383 0
ER E2-MCF7GSE14664 38228701 38228733 32 0
ER E2-MCF7GSE14664 38350210 38350248 38 0
ER MCF7GSE19013 38236641 38237209 568 0
FOXA1 MCF7GSE15244 38314266 38315178 912 0
Oct1 H2O2-HelaGSE14283 38223056 38223084 28 0
Oct1 H2O2-HelaGSE14283 38223477 38223542 65 0
Oct1 H2O2-HelaGSE14283 38296558 38296593 35 0
Oct1 H2O2-HelaGSE14283 38346214 38346245 31 0
Oct1 HelaGSE14283 38170063 38170104 41 0
Oct1 HelaGSE14283 38180024 38180101 77 0
Oct1 HelaGSE14283 38182566 38182626 60 0
Oct1 HelaGSE14283 38192373 38192408 35 0
Oct1 HelaGSE14283 38223477 38223532 55 0
Oct1 HelaGSE14283 38236720 38236753 33 0
Oct1 HelaGSE14283 38263396 38263483 87 0
Oct1 HelaGSE14283 38276679 38276712 33 0
Oct1 HelaGSE14283 38280451 38280483 32 0
Oct1 HelaGSE14283 38310759 38310794 35 0
Oct1 HelaGSE14283 38334871 38334905 34 0
Oct1 HelaGSE14283 38342941 38342979 38 0
Oct1 HelaGSE14283 38346212 38346248 36 0
RARA MCF7GSE15244 38176330 38176798 468 0
TFAP2C MCF7GSE21234 38298351 38298898 547 0
hScc1 CdLSGSE12603 38344746 38345239 493 0
hScc1 G2GSE9613 38235898 38236355 457 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
7085 mRNA FREM2 chr13 38255292 38358072 5908 EST chr13 38293820 38299728 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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