AutismKB 2.0

Annotation Detail for IL6ST


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Basic Information Top
Gene Symbol:IL6ST ( CD130,CDW130,DKFZp564F053,GP130,IL-6RB )
Gene Full Name: interleukin 6 signal transducer (gp130, oncostatin M receptor)
Band: 5q11.2
Quick LinksEntrez ID:3572; OMIM: 600694; Uniprot ID:IL6RB_HUMAN; ENSEMBL ID: ENSG00000134352; HGNC ID: 6021
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
43N-linked (GlcNAc...).
83N-linked (GlcNAc...).
131N-linked (GlcNAc...).
157N-linked (GlcNAc...).
227N-linked (GlcNAc...).
314WSXWS motif.
379N-linked (GlcNAc...).
383N-linked (GlcNAc...).
390N-linked (GlcNAc...).
553N-linked (GlcNAc...).
564N-linked (GlcNAc...).
659Box 1 motif.
667Phosphoserine.
782Phosphoserine.
820Phosphoserine.
829Phosphoserine.
Location(AA) Modifications Resource
43N-linked (GlcNAc...).Swiss-Prot 53.0
83N-linked (GlcNAc...).Swiss-Prot 53.0
131N-linked (GlcNAc...).Swiss-Prot 53.0
157N-linked (GlcNAc...).Swiss-Prot 53.0
227N-linked (GlcNAc...).Swiss-Prot 53.0
379N-linked (GlcNAc...).Swiss-Prot 53.0
383N-linked (GlcNAc...).Swiss-Prot 53.0
553N-linked (GlcNAc...).Swiss-Prot 53.0
564N-linked (GlcNAc...).Swiss-Prot 53.0
667PhosphoserinePhospho.ELM 6.0
667Phosphoserine.Swiss-Prot 53.0
683Phosphotyrosine (JAK1;JAK2)Phospho.ELM 6.0
759PhosphotyrosinePhospho.ELM 6.0
767PhosphotyrosinePhospho.ELM 6.0
782Phosphoserine.Swiss-Prot 53.0
782PhosphoserinePhospho.ELM 6.0
814PhosphotyrosinePhospho.ELM 6.0
820Phosphoserine.Swiss-Prot 53.0
820PhosphoserinePhospho.ELM 6.0
829Phosphoserine.Swiss-Prot 53.0
829PhosphoserinePhospho.ELM 6.0
890Phosphothreonine (PKC delta)Phospho.ELM 6.0
905PhosphotyrosinePhospho.ELM 6.0
915PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
30Phosphotyrosine(Jak)HMM predict
30Phosphotyrosine(Syk)HMM predict
30Phosphotyrosine(INSR)HMM predict
43N-linkedHMM predict
83N-linkedHMM predict
90O-linkedHMM predict
157N-linkedHMM predict
178Phosphothreonine(MAPK)HMM predict
183O-linkedHMM predict
279O-linkedHMM predict
295Phosphotyrosine(Jak)HMM predict
379N-linkedHMM predict
383N-linkedHMM predict
390N-linkedHMM predict
393N-linkedHMM predict
449Phosphoserine(PKG)HMM predict
506Phosphoserine(CDC2)HMM predict
520O-linkedHMM predict
524Phosphothreonine(PKC)HMM predict
553N-linkedHMM predict
564N-linkedHMM predict
569N-linkedHMM predict
578O-linkedHMM predict
670Phosphothreonine(CDK)HMM predict
670Phosphothreonine(MAPK)HMM predict
670Phosphothreonine(CDC2)HMM predict
683Phosphotyrosine(Jak)HMM predict
687N-linkedHMM predict
721Phosphothreonine(PKC)HMM predict
735Phosphoserine(CK1)HMM predict
740Phosphoserine(CK1)HMM predict
740Phosphoserine(IKK)HMM predict
742Phosphoserine(CK2)HMM predict
743Phosphoserine(CK1)HMM predict
747N-linkedHMM predict
749Phosphoserine(CK2)HMM predict
750Phosphoserine(ATM)HMM predict
750Phosphoserine(CK1)HMM predict
752N-linkedHMM predict
753O-linkedHMM predict
761Phosphothreonine(PKC)HMM predict
761O-linkedHMM predict
818N-linkedHMM predict
820Phosphoserine(ATM)HMM predict
824Phosphoserine(CK2)HMM predict
857Phosphoserine(ATM)HMM predict
905Phosphotyrosine(Jak)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002184
  • Location:chr5 55272451-55326519
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 55345027 55345303 276 18646
Fos K562GSE19551 55326351 55327045 694 179
FoxA1 MCF7MACSdata 55345007 55345253 246 18611
KLF4 hESGSE17917 55326941 55327100 159 501
Oct1 H2O2-HelaGSE14283 55344574 55344604 30 18070
Oct1 HelaGSE14283 55344574 55344604 30 18070
PHF8 HeLaGSE20725 55325936 55327283 1347 90
PHF8 Hs68plusFBSGSE20725 55325863 55327534 1671 179
STAT1 HeLaGSE12782 55325807 55327892 2085 330
USF1 HepG2E 55344393 55344638 245 17996
hScc1 BcellGSE12603 55326075 55327072 997 54
hScc1 CdLSGSE12603 55325897 55327605 1708 232
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 55267649 55268032 383 4611
CTCF CD4SISSRdata 55267649 55268032 383 4611
CTCF HelaGSE12889 55267593 55267953 360 4679
CTCF G2GSE9613 55264930 55265333 403 7320
CTCF G2GSE9613 55267643 55268110 467 4575
FOXA1 MCF7GSE15244 55265297 55266345 1048 6631
FoxA1 MCF7MACSdata 55265657 55265924 267 6661
RARA MCF7GSE15244 55265480 55266453 973 6485
USF1 HepG2E 55265086 55266381 1295 6718
USF2 HepG2E 55265152 55266129 977 6811
hScc1 BcellGSE12603 55267716 55268110 394 4539
hScc1 CdLSGSE12603 55267643 55268260 617 4500
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 55309782 55310024 242 0
CTCF CD4SISSRdata 55309782 55310024 242 0
CTCF G2GSE9613 55276219 55276472 253 0
CTCF G2GSE9613 55326248 55326496 248 0
E2F4 G0GSE7516 55276219 55276586 367 0
ER MCF7GSE19013 55293234 55293730 496 0
H3K4me3 colorectalcancer 55325418 55326358 940 0
H3ac HepG2E 55322855 55326248 3393 0
LIN9 G0GSE7516 55276219 55276586 367 0
PHF8 Hs68minusFBSGSE20725 55325964 55326633 669 0
TAF HelaGSE8489 55276219 55276586 367 0
hScc1 BcellGSE12603 55276219 55276586 367 0
p130 SenescentGSE19898 55325968 55326322 354 0
p130 G0GSE7516 55276261 55276586 325 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-19a hsa-mir-19a 13 19713220
hsa-miR-19a* hsa-mir-19a 13 19713220
hsa-miR-19b hsa-mir-19b-1 13 19713220
hsa-miR-19b hsa-mir-19b-2 X 19713220
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20975 EST chr5 55267727 55273312 572 mRNA IL6ST chr5 55272451 55326520Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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