AutismKB 2.0

Annotation Detail for INSR


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Basic Information Top
Gene Symbol:INSR ( CD220,HHF5 )
Gene Full Name: insulin receptor
Band: 19p13.2
Quick LinksEntrez ID:3643; OMIM: 147670; Uniprot ID:INSR_HUMAN; ENSEMBL ID: ENSG00000171105; HGNC ID: 6091
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
43N-linked (GlcNAc...).
52N-linked (GlcNAc...) (Potential).
105N-linked (GlcNAc...) (Potential).
138N-linked (GlcNAc...) (Potential).
242N-linked (GlcNAc...).
282N-linked (GlcNAc...) (Potential).
322N-linked (GlcNAc...) (Potential).
364N-linked (GlcNAc...) (Potential).
400Phosphoserine.
401Phosphotyrosine.
407Phosphoserine.
424N-linked (GlcNAc...) (Potential).
445N-linked (GlcNAc...).
541N-linked (GlcNAc...).
633N-linked (GlcNAc...) (Potential).
651N-linked (GlcNAc...) (Potential).
698N-linked (GlcNAc...) (Potential).
769N-linked (GlcNAc...).
782N-linked (GlcNAc...) (Potential).
920N-linked (GlcNAc...).
933N-linked (GlcNAc...) (Potential).
992Phosphotyrosine; by autocatalysis
999Phosphotyrosine; by autocatalysis.
1011Phosphotyrosine; by autocatalysis
1064Phosphoserine.
1112N6-acetyllysine.
1185Phosphotyrosine; by autocatalysis.
1189Phosphotyrosine; by autocatalysis.
1190Phosphotyrosine; by autocatalysis.
1348Phosphoserine.
1354Phosphoserine.
1355Phosphotyrosine; by autocatalysis.
1361Phosphotyrosine; by autocatalysis.
1379Phosphoserine.
Location(AA) Modifications Resource
43N-linked (GlcNAc...).Swiss-Prot 53.0
52N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
105N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
138N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
242N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
282N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
322N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
364N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
424N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
445N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
541N-linked (GlcNAc...).Swiss-Prot 53.0
633N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
651N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
698N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
769N-linked (GlcNAc...).Swiss-Prot 53.0
782N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
920N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
933N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
992Phosphotyrosine (by autocatalysis)(Probable).Swiss-Prot 53.0
992Phosphotyrosine (InsR)Phospho.ELM 6.0
999Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
999Phosphotyrosine (InsR)Phospho.ELM 6.0
1011Phosphotyrosine (InsR)Phospho.ELM 6.0
1011Phosphotyrosine (by autocatalysis)(Probable).Swiss-Prot 53.0
1062Phosphoserine (PKC alpha)Phospho.ELM 6.0
1064Phosphoserine (PKC alpha)Phospho.ELM 6.0
1185Phosphotyrosine (InsR)Phospho.ELM 6.0
1185Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1189Phosphotyrosine (InsR)Phospho.ELM 6.0
1189Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1190Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1190Phosphotyrosine (InsR)Phospho.ELM 6.0
1332PhosphoserinePhospho.ELM 6.0
1333PhosphoserinePhospho.ELM 6.0
1348PhosphoserinePhospho.ELM 6.0
1354PhosphoserinePhospho.ELM 6.0
1355Phosphotyrosine (InsR)Phospho.ELM 6.0
1355Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1361Phosphotyrosine (InsR)Phospho.ELM 6.0
1361Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1375Phosphothreonine (PKC alpha;PK)Phospho.ELM 6.0
Location(AA) Modification Resource
43N-linkedHMM predict
105N-linkedHMM predict
134Phosphotyrosine(INSR)HMM predict
138N-linkedHMM predict
171Phosphotyrosine(INSR)HMM predict
242N-linkedHMM predict
244Phosphoserine(ATM)HMM predict
282N-linkedHMM predict
322N-linkedHMM predict
325N-linkedHMM predict
331S-palmitoylHMM predict
364N-linkedHMM predict
370N-linkedHMM predict
445N-linkedHMM predict
504Phosphotyrosine(Jak)HMM predict
539Phosphotyrosine(SRC)HMM predict
541N-linkedHMM predict
572Phosphoserine(ATM)HMM predict
605Phosphothreonine(PKC)HMM predict
614SulfotyrosineHMM predict
621N-linkedHMM predict
633N-linkedHMM predict
634Phosphoserine(CK1)HMM predict
651N-linkedHMM predict
694Phosphoserine(CK1)HMM predict
694Phosphoserine(ATM)HMM predict
698N-linkedHMM predict
702SulfotyrosineHMM predict
702Phosphotyrosine(Syk)HMM predict
747Phosphoserine(PKG)HMM predict
747Phosphoserine(PKA)HMM predict
769N-linkedHMM predict
782N-linkedHMM predict
783O-linkedHMM predict
784O-linkedHMM predict
787Phosphoserine(IKK)HMM predict
787Phosphoserine(ATM)HMM predict
791Phosphoserine(ATM)HMM predict
791Phosphoserine(CDC2)HMM predict
791Phosphoserine(IKK)HMM predict
791PhosphoserineHMM predict
929Phosphoserine(IKK)HMM predict
933N-linkedHMM predict
941Phosphotyrosine(SRC)HMM predict
947Phosphotyrosine(Syk)HMM predict
999Phosphotyrosine(INSR)HMM predict
1058Phosphothreonine(PKC)HMM predict
1185SulfotyrosineHMM predict
1185Phosphotyrosine(Syk)HMM predict
1189PhosphotyrosineHMM predict
1237Phosphotyrosine(Syk)HMM predict
1266Phosphothreonine(PKA)HMM predict
1314Phosphoserine(CK2)HMM predict
1354PhosphoserineHMM predict
1355Phosphotyrosine(EGFR)HMM predict
1375Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000208
  • Location:chr19 7067641-7245010
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 7246272 7246833 561 1542
CTCF G2GSE9613 7245880 7246200 320 1030
FOXA1 MCF7GSE15244 7247208 7247470 262 2329
KLF4 hESGSE17917 7245351 7245663 312 497
Oct1 H2O2-HelaGSE14283 7251733 7251764 31 6738
Oct1 H2O2-HelaGSE14283 7257513 7257547 34 12520
Oct1 HelaGSE14283 7248850 7248918 68 3874
Oct1 HelaGSE14283 7249039 7249070 31 4044
Oct1 HelaGSE14283 7251730 7251761 31 6735
Oct1 HelaGSE14283 7257513 7257548 35 12520
Oct1 HelaGSE14283 7258122 7258160 38 13131
P300 T30-glioblastomaGSE21026 7260494 7261589 1095 16031
Rb SenescentGSE19898 7245255 7245666 411 450
hScc1 BcellGSE12603 7245880 7246491 611 1175
hScc1 CdLSGSE12603 7245880 7246491 611 1175
p130 QuiescentGSE19898 7245349 7245581 232 455
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 7053404 7053654 250 14113
CTCF CD4SISSRdata 7053404 7053654 250 14113
CTCF G2GSE9613 7053403 7053651 248 14115
NRSF JurkatGSE13047 7064242 7064700 458 3171
NRSF mAbJurkat 7057347 7057656 309 10140
NRSF mAbJurkat 7062746 7066144 3398 3197
NRSF-mono JurkatQuESTdata 7064241 7064699 458 3172
NRSF-poly JurkatQuESTdata 7064209 7064757 548 3159
Nanog hESGSE18292 7061067 7061446 379 6385
Sox2 hESGSE18292 7053436 7053643 207 14102
TAF k562GSE8489 7057347 7057656 309 10140
hScc1 BcellGSE12603 7053403 7053651 248 14115
hScc1 CdLSGSE12603 7053403 7053651 248 14115
hScc1 G2GSE9613 7053403 7053651 248 14115
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 7075554 7075949 395 0
CBP T30-glioblastomaGSE21026 7238659 7239378 719 0
CTCF CD4GSE12889 7100220 7100427 207 0
CTCF CD4SISSRdata 7100220 7100427 207 0
CTCF G2GSE9613 7094125 7094340 215 0
CTCF G2GSE9613 7100223 7100508 285 0
ER Fulvestrant-MCF7GSE14664 7094671 7094712 41 0
ER MCF7GSE19013 7205416 7206511 1095 0
Fos K562GSE19551 7088154 7088607 453 0
Fos K562GSE19551 7170788 7171197 409 0
Fos K562GSE19551 7208193 7208573 380 0
FoxA1 MCF7MACSdata 7095835 7096076 241 0
FoxA1 MCF7MACSdata 7096561 7096843 282 0
H3K4me3 colorectalcancer 7243874 7244472 598 0
H3ac HepG2E 7243634 7244331 697 0
HIF1 HypoHepG2 7148120 7148493 373 0
NFkBII GM10847GSE19485 7129759 7130976 1217 0
NFkBII GM10847GSE19485 7167228 7168259 1031 0
NFkBII GM12878GSE19485 7129618 7131312 1694 0
NFkBII GM12878GSE19485 7166864 7168920 2056 0
NFkBII GM12892GSE19485 7167177 7168173 996 0
Nanog hESGSE18292 7235444 7235611 167 0
Oct1 H2O2-HelaGSE14283 7074687 7074728 41 0
Oct1 H2O2-HelaGSE14283 7090912 7090945 33 0
Oct1 H2O2-HelaGSE14283 7137619 7137667 48 0
Oct1 HelaGSE14283 7074687 7074775 88 0
Oct1 HelaGSE14283 7075011 7075038 27 0
Oct1 HelaGSE14283 7089482 7089515 33 0
Oct1 HelaGSE14283 7090913 7090945 32 0
Oct1 HelaGSE14283 7094664 7094706 42 0
Oct1 HelaGSE14283 7108138 7108185 47 0
Oct1 HelaGSE14283 7124148 7124207 59 0
Oct1 HelaGSE14283 7137627 7137667 40 0
Oct1 HelaGSE14283 7138494 7138525 31 0
Oct1 HelaGSE14283 7241683 7241716 33 0
Oct1 HelaGSE14283 7244712 7244787 75 0
Oct4 hESGSE17917 7175852 7176115 263 0
P300 T0-glioblastomaGSE21026 7075195 7075768 573 0
P300 T0-glioblastomaGSE21026 7238480 7239204 724 0
P300 T30-glioblastomaGSE21026 7238485 7239179 694 0
PHF8 HeLaGSE20725 7148652 7149868 1216 0
RNAII Tamoxifen-MCF7GSE14664 7078650 7078708 58 0
RNAII Tamoxifen-MCF7GSE14664 7094669 7094709 40 0
RNAII Tamoxifen-MCF7GSE14664 7137628 7137665 37 0
SRF k562GSE8489 7230334 7230658 324 0
TAF k562GSE8489 7116324 7116546 222 0
TAF k562GSE8489 7230334 7230689 355 0
TFAP2C MCF7GSE21234 7096537 7096879 342 0
TFAP2C MCF7GSE21234 7148151 7148623 472 0
TFAP2C MCF7GSE21234 7148678 7149264 586 0
TFAP2C MCF7GSE21234 7191278 7191705 427 0
TFAP2C MCF7GSE21234 7208652 7209006 354 0
USF1 HepG2E 7165390 7165608 218 0
USF1 HepG2E 7169949 7170416 467 0
VDR GM10855-stimGSE22484 7223206 7224719 1513 0
hScc1 BcellGSE12603 7083010 7083259 249 0
hScc1 BcellGSE12603 7100223 7100508 285 0
hScc1 BcellGSE12603 7148050 7148493 443 0
hScc1 BcellGSE12603 7243713 7244165 452 0
hScc1 CdLSGSE12603 7100223 7100508 285 0
hScc1 CdLSGSE12603 7148050 7148493 443 0
hScc1 G2GSE9613 7100223 7100508 285 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-199a-5p hsa-mir-199a-1 19 20193759
hsa-miR-199a-5p hsa-mir-199a-2 1 20193759
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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