AutismKB 2.0

Annotation Detail for IRAK2


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Basic Information Top
Gene Symbol:IRAK2 ( IRAK-2,MGC150550 )
Gene Full Name: interleukin-1 receptor-associated kinase 2
Band: 3p25.3
Quick LinksEntrez ID:3656; OMIM: 603304; Uniprot ID:IRAK2_HUMAN; ENSEMBL ID: ENSG00000134070; HGNC ID: 6113
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
368Phosphothreonine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
144Phosphoserine(CDC2)HMM predict
144O-linkedHMM predict
164Phosphoserine(MAPK)HMM predict
175O-linkedHMM predict
217Phosphoserine(PKG)HMM predict
264S-palmitoylHMM predict
265S-palmitoylHMM predict
286SulfotyrosineHMM predict
291N-linkedHMM predict
314Phosphoserine(IKK)HMM predict
367Phosphotyrosine(INSR)HMM predict
418N-linkedHMM predict
434Phosphoserine(CK2)HMM predict
434Phosphoserine(CK1)HMM predict
436O-linkedHMM predict
438Phosphoserine(PKA)HMM predict
438Phosphoserine(IKK)HMM predict
479S-palmitoylHMM predict
481S-palmitoylHMM predict
486N-linkedHMM predict
487Phosphothreonine(PKA)HMM predict
488Phosphoserine(PKB)HMM predict
495Phosphoserine(IKK)HMM predict
521O-linkedHMM predict
521Phosphoserine(CK2)HMM predict
522O-linkedHMM predict
525O-linkedHMM predict
525Phosphothreonine(CDC2)HMM predict
525Phosphothreonine(MAPK)HMM predict
525Phosphothreonine(CDK)HMM predict
575Phosphoserine(CK1)HMM predict
609IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001570
  • Location:chr3 10181562-10260426
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 10181379 10181650 271 48
CTCF CD4SISSRdata 10181379 10181650 271 48
CTCF HelaGSE12889 10181314 10181596 282 108
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 10208132 10209542 1410 0
CTCF CD4GSE12889 10209652 10209790 138 0
CTCF CD4GSE12889 10241617 10241891 274 0
CTCF CD4SISSRdata 10209652 10209790 138 0
CTCF CD4SISSRdata 10241617 10241891 274 0
CTCF HelaGSE12889 10241502 10241886 384 0
CTCF G2GSE9613 10181275 10182089 814 0
CTCF G2GSE9613 10187530 10187887 357 0
CTCF G2GSE9613 10194148 10194529 381 0
CTCF G2GSE9613 10196878 10197355 477 0
CTCF G2GSE9613 10211473 10211713 240 0
CTCF G2GSE9613 10212485 10212768 283 0
CTCF G2GSE9613 10222096 10222284 188 0
CTCF G2GSE9613 10222897 10223195 298 0
FOXA1 MCF7GSE15244 10208008 10209111 1103 0
FOXA1 MCF7GSE15244 10220616 10221168 552 0
Fos K562GSE19551 10189751 10191067 1316 0
Fos K562GSE19551 10251455 10252119 664 0
FoxA1 MCF7MACSdata 10220630 10220950 320 0
Gata2 K562GSE18868 10185858 10186366 508 0
H3ac HepG2E 10210341 10210523 182 0
H3ac HepG2E 10212338 10212731 393 0
NFkBII GM12878GSE19485 10208028 10210468 2440 0
NFkBII GM12878GSE19485 10214733 10216606 1873 0
NFkBII GM12892GSE19485 10208158 10210515 2357 0
Nanog ESGSE20650 10242930 10243507 577 0
Nanog hESGSE18292 10243071 10243337 266 0
Oct1 H2O2-HelaGSE14283 10212234 10212264 30 0
Oct1 HelaGSE14283 10225663 10225696 33 0
Oct1 HelaGSE14283 10252193 10252269 76 0
P300 T30-glioblastomaGSE21026 10208460 10210367 1907 0
P300 T30-glioblastomaGSE21026 10221781 10223006 1225 0
RARA MCF7GSE15244 10208359 10209980 1621 0
RARA MCF7GSE15244 10215368 10216291 923 0
RARA MCF7GSE15244 10220616 10221168 552 0
RARA MCF7GSE15244 10222061 10222284 223 0
RARA MCF7GSE15244 10223950 10224354 404 0
RARG MCF7GSE15244 10208008 10209111 1103 0
RARG MCF7GSE15244 10209608 10209980 372 0
RARG MCF7GSE15244 10220616 10221168 552 0
RARG MCF7GSE15244 10223950 10224354 404 0
TFAP2C MCF7GSE21234 10185809 10186316 507 0
TFAP2C MCF7GSE21234 10208365 10209219 854 0
VDR GM10855-stimGSE22484 10236853 10238257 1404 0
VDR GM10861-stimGSE22484 10236749 10238115 1366 0
VDR GM10861-stimGSE22484 10239819 10242495 2676 0
hScc1 BcellGSE12603 10181275 10182089 814 0
hScc1 BcellGSE12603 10217967 10218496 529 0
hScc1 BcellGSE12603 10223048 10223195 147 0
hScc1 BcellGSE12603 10243112 10243285 173 0
hScc1 BcellGSE12603 10255894 10256085 191 0
hScc1 CdLSGSE12603 10181275 10181953 678 0
hScc1 CdLSGSE12603 10208437 10209076 639 0
hScc1 CdLSGSE12603 10209638 10209980 342 0
hScc1 CdLSGSE12603 10241242 10242107 865 0
p130 QuiescentGSE19898 10209736 10209859 123 0
p130 SenescentGSE19898 10222198 10222731 533 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 18508790
hsa-let-7a hsa-let-7a-2 11 18508790
hsa-let-7a hsa-let-7a-3 22 18508790
hsa-let-7g hsa-let-7g 3 19284987
hsa-let-7g* hsa-let-7g 3 19284987
hsa-miR-143 hsa-mir-143 5 19284987
hsa-miR-143 hsa-mir-143 5 18508790
hsa-miR-143* hsa-mir-143 5 19284987
hsa-miR-143* hsa-mir-143 5 18508790
hsa-miR-145 hsa-mir-145 5 18508790
hsa-miR-145* hsa-mir-145 5 18508790
hsa-miR-146a hsa-mir-146a 5 20937840
hsa-miR-146a hsa-mir-146a 5 19596990
hsa-miR-146a* hsa-mir-146a 5 20937840
hsa-miR-146a* hsa-mir-146a 5 19596990
hsa-miR-146b-3p hsa-mir-146b 10 19284987
hsa-miR-146b-5p hsa-mir-146b 10 19284987
hsa-miR-150 hsa-mir-150 19 19284987
hsa-miR-150 hsa-mir-150 19 18508790
hsa-miR-150* hsa-mir-150 19 19284987
hsa-miR-150* hsa-mir-150 19 18508790
hsa-miR-182 hsa-mir-182 7 18508790
hsa-miR-182* hsa-mir-182 7 18508790
hsa-miR-223 hsa-mir-223 X 18508790
hsa-miR-223* hsa-mir-223 X 18508790
hsa-miR-26b hsa-mir-26b 2 18508790
hsa-miR-26b* hsa-mir-26b 2 18508790
hsa-miR-30b hsa-mir-30b 8 18508790
hsa-miR-30b* hsa-mir-30b 8 18508790
hsa-miR-30c hsa-mir-30c-2 6 18508790
hsa-miR-30c hsa-mir-30c-1 1 18508790
hsa-miR-342-3p hsa-mir-342 14 19284987
hsa-miR-342-3p hsa-mir-342 14 18508790
hsa-miR-342-5p hsa-mir-342 14 19284987
hsa-miR-342-5p hsa-mir-342 14 18508790
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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