AutismKB 2.0

Annotation Detail for IREB2


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Basic Information Top
Gene Symbol:IREB2 ( ACO3,FLJ23381,IRP2,IRP2AD )
Gene Full Name: iron-responsive element binding protein 2
Band: 15q25.1
Quick LinksEntrez ID:3658; OMIM: 147582; Uniprot ID:IREB2_HUMAN; ENSEMBL ID: ENSG00000136381; HGNC ID: 6115
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
157Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
18N-linkedHMM predict
157Phosphoserine(CDC2)HMM predict
361Phosphoserine(ATM)HMM predict
389N-linkedHMM predict
423N-linkedHMM predict
425Phosphoserine(CK2)HMM predict
430Phosphotyrosine(Abl)HMM predict
430Phosphotyrosine(SRC)HMM predict
430Phosphotyrosine(EGFR)HMM predict
431Phosphoserine(ATM)HMM predict
431Phosphoserine(CK1)HMM predict
547Phosphoserine(CDC2)HMM predict
580O-linkedHMM predict
628Phosphoserine(MAPK)HMM predict
765Phosphoserine(PKG)HMM predict
777Phosphothreonine(MAPK)HMM predict
939Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004136
  • Location:chr15 76517680-76578521
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 76502303 76502593 290 15233
CTCF CD4SISSRdata 76502303 76502593 290 15233
CTCF HelaGSE12889 76502330 76502635 305 15198
CTCF G2GSE9613 76502232 76502496 264 15317
ER E2-MCF7GSE14664 76513720 76513756 36 3943
ETS1 JurkatGSE17954 76516829 76518175 1346 179
H3K4me3 colorectalcancer 76516914 76517224 310 612
H3ac HepG2E 76516694 76517548 854 560
Myc K562GSE19551 76502289 76502615 326 15229
Oct1 H2O2-HelaGSE14283 76500609 76500641 32 17056
Oct1 H2O2-HelaGSE14283 76507707 76507744 37 9955
Oct1 H2O2-HelaGSE14283 76513711 76513739 28 3956
Oct1 HelaGSE14283 76500610 76500641 31 17055
Oct1 HelaGSE14283 76502271 76502326 55 15382
Oct1 HelaGSE14283 76507698 76507744 46 9960
Oct1 HelaGSE14283 76513711 76513739 28 3956
P300 T30-glioblastomaGSE21026 76516774 76517963 1189 312
TAF HelaGSE8489 76516694 76517468 774 600
USF1 HepG2E 76501103 76501333 230 16463
hScc1 BcellGSE12603 76502232 76502496 264 15317
hScc1 BcellGSE12603 76517019 76517583 564 380
hScc1 CdLSGSE12603 76502232 76502533 301 15298
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 76561756 76562039 283 0
CTCF CD4SISSRdata 76561756 76562039 283 0
CTCF G2GSE9613 76561657 76561863 206 0
ER E2-MCF7GSE14664 76559950 76560029 79 0
FoxA1 MCF7MACSdata 76536525 76536756 231 0
H3ac HepG2E 76518104 76519509 1405 0
Myc K562GSE19551 76561809 76562097 288 0
Nanog hESGSE18292 76561667 76562255 588 0
Oct1 H2O2-HelaGSE14283 76535324 76535352 28 0
Oct1 HelaGSE14283 76535321 76535355 34 0
Oct1 HelaGSE14283 76573717 76573752 35 0
PHF8 HeLaGSE20725 76517014 76518505 1491 0
STAT1 HeLaGSE12783 76527718 76529405 1687 0
Sox2 hESGSE18292 76561850 76562043 193 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018