AutismKB 2.0

Annotation Detail for IRF2


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Basic Information Top
Gene Symbol:IRF2 ( DKFZp686F0244,IRF-2 )
Gene Full Name: interferon regulatory factor 2
Band: 4q35.1
Quick LinksEntrez ID:3660; OMIM: 147576; Uniprot ID:IRF2_HUMAN; ENSEMBL ID: ENSG00000168310; HGNC ID: 6117
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
75N6-acetyllysine.
78N6-acetyllysine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
119Phosphoserine(CK1)HMM predict
207Phosphothreonine(CK2)HMM predict
215Phosphoserine(IKK)HMM predict
225Phosphoserine(CDK)HMM predict
235O-linkedHMM predict
238Phosphoserine(IKK)HMM predict
241Phosphoserine(CK2)HMM predict
241Phosphoserine(CK1)HMM predict
245Phosphoserine(CK1)HMM predict
302N-linkedHMM predict
318O-linkedHMM predict
318Phosphothreonine(MAPK)HMM predict
318Phosphothreonine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002199
  • Location:chr4 185545909-185632696
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 185633274 185633538 264 710
H3K4me3 colorectalcancer 185633237 185634061 824 953
H3ac HepG2E 185633130 185634061 931 899
H3ac HepG2E 185634859 185635398 539 2432
Rb GrowingGSE19898 185632630 185632999 369 118
Rb GrowingGSE19898 185633457 185633700 243 882
Rb QuiescentGSE19898 185632824 185633008 184 220
STAT1 HeLaGSE12782 185631773 185634119 2346 250
hScc1 BcellGSE12603 185635467 185635989 522 3032
p130 shRbQuiescentGSE19898 185632903 185633905 1002 708
p130 shRbSenescentGSE19898 185632656 185633028 372 146
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 185534582 185534878 296 11180
P300 T30-glioblastomaGSE21026 185541262 185542892 1630 3833
hScc1 BcellGSE12603 185529592 185529812 220 16208
hScc1 BcellGSE12603 185542526 185542910 384 3192
p63 keratinocytesGSE17611 185541621 185543361 1740 3419
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 185554244 185554498 254 0
CTCF G2GSE9613 185557051 185557433 382 0
CTCF G2GSE9613 185586959 185587379 420 0
CTCF G2GSE9613 185598212 185598443 231 0
CTCF G2GSE9613 185607191 185607332 141 0
CTCF G2GSE9613 185615106 185615406 300 0
CTCF G2GSE9613 185631046 185631960 914 0
Fos K562GSE19551 185575859 185576482 623 0
H3ac HepG2E 185597927 185599610 1683 0
H3ac HepG2E 185632092 185632699 607 0
KLF4 hESGSE17917 185562515 185562716 201 0
NFkBII GM10847GSE19485 185630215 185634026 3811 0
NFkBII GM15510GSE19485 185629435 185634078 4643 0
P300 T30-glioblastomaGSE21026 185575796 185576682 886 0
Rb shRbQuiescentGSE19898 185587339 185587599 260 0
VDR GM10861-stimGSE22484 185567110 185569373 2263 0
hScc1 BcellGSE12603 185557196 185557592 396 0
hScc1 BcellGSE12603 185566718 185566932 214 0
hScc1 BcellGSE12603 185583485 185583756 271 0
hScc1 BcellGSE12603 185603055 185603485 430 0
hScc1 BcellGSE12603 185630300 185633643 3343 0
hScc1 CdLSGSE12603 185630270 185633643 3373 0
p130 SenescentGSE19898 185565859 185566142 283 0
p130 SenescentGSE19898 185566342 185566524 182 0
p130 shRbQuiescentGSE19898 185607010 185607457 447 0
p63 keratinocytesGSE17611 185575540 185576742 1202 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-569 hsa-mir-569 3 21360505
hsa-miR-569 hsa-mir-569 3 21162035
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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