AutismKB 2.0

Annotation Detail for ITGA2


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Basic Information Top
Gene Symbol:ITGA2 ( BR,CD49B,GPIa,VLA-2,VLAA2 )
Gene Full Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Band: 5q11.2
Quick LinksEntrez ID:3673; OMIM: 192974; Uniprot ID:ITA2_HUMAN; ENSEMBL ID: ENSG00000164171; HGNC ID: 6137
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
105N-linked (GlcNAc...) (Potential).
112N-linked (GlcNAc...) (Potential).
343N-linked (GlcNAc...).
432N-linked (GlcNAc...) (Potential).
460N-linked (GlcNAc...) (Potential).
475N-linked (GlcNAc...) (Potential).
699N-linked (GlcNAc...) (Potential).
1057N-linked (GlcNAc...) (Potential).
1074N-linked (GlcNAc...) (Potential).
1081N-linked (GlcNAc...) (Potential).
1161GFFKR motif.
1177Phosphothreonine.
Location(AA) Modifications Resource
105N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
112N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
343N-linked (GlcNAc...).Swiss-Prot 53.0
432N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
460N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
475N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
699N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1057N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1074N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1081N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
105N-linkedHMM predict
163O-linkedHMM predict
163Phosphoserine(CDC2)HMM predict
240Phosphoserine(IKK)HMM predict
273Phosphoserine(PKG)HMM predict
273Phosphoserine(PKA)HMM predict
275Phosphothreonine(PKA)HMM predict
345Phosphoserine(CK2)HMM predict
389Phosphoserine(ATM)HMM predict
389Phosphoserine(CK2)HMM predict
432N-linkedHMM predict
445O-linkedHMM predict
460N-linkedHMM predict
475N-linkedHMM predict
576Phosphoserine(CDC2)HMM predict
625Phosphotyrosine(INSR)HMM predict
699N-linkedHMM predict
916Phosphoserine(CK1)HMM predict
916Phosphoserine(ATM)HMM predict
916PhosphoserineHMM predict
981O-linkedHMM predict
985Phosphoserine(IKK)HMM predict
1054O-linkedHMM predict
1057N-linkedHMM predict
1074N-linkedHMM predict
1081N-linkedHMM predict
1095O-linkedHMM predict
1108SulfotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002203
  • Location:chr5 52320912-52426364
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Myc hESGSE17917 52320587 52320948 361 145
RARA MCF7GSE15244 52318964 52320235 1271 1313
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 52427540 52427895 355 1353
CTCF CD4SISSRdata 52427540 52427895 355 1353
hScc1 BcellGSE12603 52427514 52427897 383 1341
hScc1 CdLSGSE12603 52427413 52427932 519 1308
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 52320568 52321440 872 0
CTCF G2GSE9613 52367605 52367921 316 0
ER E2-MCF7GSE14664 52353425 52353500 75 0
ER Fulvestrant-MCF7GSE14664 52392156 52392188 32 0
ER MCF7GSE19013 52421737 52422262 525 0
Fos K562GSE19551 52350835 52351400 565 0
FoxA1 MCF7MACSdata 52350870 52351184 314 0
Oct1 HelaGSE14283 52368144 52368211 67 0
Oct1 HelaGSE14283 52379670 52379739 69 0
Oct1 HelaGSE14283 52385325 52385355 30 0
Oct1 HelaGSE14283 52392160 52392189 29 0
RARA MCF7GSE15244 52420814 52422165 1351 0
RNAII Tamoxifen-MCF7GSE14664 52353413 52353517 104 0
RNAII Tamoxifen-MCF7GSE14664 52388613 52388660 47 0
Rb shRbSenescenceGSE19898 52342947 52343110 163 0
TFAP2C MCF7GSE21234 52421871 52422323 452 0
hScc1 BcellGSE12603 52321295 52321664 369 0
hScc1 BcellGSE12603 52367498 52367921 423 0
hScc1 G2GSE9613 52320568 52321553 985 0
p130 SenescentGSE19898 52327326 52327489 163 0
p63 keratinocytesGSE17611 52359404 52360192 788 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1061 Unknown pSILAC miR-16 ITGA2 down 50-25% 18668040
1238 Unknown pSILAC miR-30 ITGA2 down 75-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000164171 n_a n_a n_a "lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000164171 n_a n_a n_a "lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20945 mRNA ITGA2 chr5 52321013 52423947 103 EST chr5 52410153 52410525Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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