AutismKB 2.0

Annotation Detail for ITGA4


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Basic Information Top
Gene Symbol:ITGA4 ( CD49D,IA4,MGC90518 )
Gene Full Name: integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Band: 2q31.3
Quick LinksEntrez ID:3676; OMIM: 192975; Uniprot ID:ITA4_HUMAN; ENSEMBL ID: ENSG00000115232; HGNC ID: 6140
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
79N-linked (GlcNAc...) (Potential).
138N-linked (GlcNAc...) (Potential).
229N-linked (GlcNAc...) (Potential).
480N-linked (GlcNAc...).
518N-linked (GlcNAc...).
538N-linked (GlcNAc...).
616SG1.
626N-linked (GlcNAc...) (Potential).
645N-linked (GlcNAc...).
660N-linked (GlcNAc...) (Potential).
806N-linked (GlcNAc...) (Potential).
821N-linked (GlcNAc...) (Potential).
1007GFFKR motif.
1021Phosphoserine.
Location(AA) Modifications Resource
85N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
144N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
235N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
486N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
524N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
544N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
632N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
651N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
666N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
812N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
827N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1027Phosphoserine.Swiss-Prot 53.0
1027Phosphoserine (PKA
Location(AA) Modification Resource
85N-linkedHMM predict
90N-linkedHMM predict
144N-linkedHMM predict
150S-palmitoylHMM predict
168Phosphothreonine(PKC)HMM predict
235N-linkedHMM predict
239N-linkedHMM predict
370Phosphotyrosine(Syk)HMM predict
421Phosphoserine(ATM)HMM predict
441Phosphoserine(ATM)HMM predict
451Phosphotyrosine(Syk)HMM predict
451Phosphotyrosine(INSR)HMM predict
486N-linkedHMM predict
544N-linkedHMM predict
598Phosphoserine(PKG)HMM predict
599Phosphothreonine(PKA)HMM predict
599Phosphothreonine(PKC)HMM predict
651N-linkedHMM predict
654Phosphotyrosine(Syk)HMM predict
677Phosphotyrosine(EGFR)HMM predict
677Phosphotyrosine(Syk)HMM predict
740Phosphoserine(CK1)HMM predict
749Phosphoserine(CK1)HMM predict
771Phosphothreonine(PKC)HMM predict
789N-linkedHMM predict
812N-linkedHMM predict
837Phosphoserine(IKK)HMM predict
930Phosphoserine(PKG)HMM predict
1036AsparagineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000885
  • Location:chr2 182029863-182110710
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 182027697 182031934 4237 48
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 182081774 182082324 550 0
CTCF CD4GSE12889 182030098 182030404 306 0
CTCF CD4SISSRdata 182030098 182030404 306 0
CTCF G2GSE9613 182030186 182030375 189 0
CTCF G2GSE9613 182039618 182039929 311 0
FOXA1 MCF7GSE15244 182058279 182058883 604 0
GABP k562GSE8489 182035098 182035275 177 0
STAT1 IFNSISSRdata 182047108 182047663 555 0
hScc1 BcellGSE12603 182029758 182030666 908 0
hScc1 BcellGSE12603 182039618 182040046 428 0
hScc1 CdLSGSE12603 182029730 182030484 754 0
hScc1 CdLSGSE12603 182039518 182040003 485 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
15358 mRNA ITGA4 chr2 182212416 182227996 1085 mRNA CERKL chr2 182226911 182347257Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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