AutismKB 2.0

Annotation Detail for ITGAL


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Basic Information Top
Gene Symbol:ITGAL ( CD11A,LFA-1,LFA1A )
Gene Full Name: integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Band: 16p11.2
Quick LinksEntrez ID:3683; OMIM: 153370; Uniprot ID:ITAL_HUMAN; ENSEMBL ID: ENSG00000005844; HGNC ID: 6148
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
65N-linked (GlcNAc...) (Potential).
89N-linked (GlcNAc...) (Potential).
188N-linked (GlcNAc...).
649N-linked (GlcNAc...) (Potential).
670N-linked (GlcNAc...) (Potential).
726N-linked (GlcNAc...) (Potential).
730N-linked (GlcNAc...) (Potential).
862N-linked (GlcNAc...) (Potential).
885N-linked (GlcNAc...) (Potential).
897N-linked (GlcNAc...) (Potential).
1060N-linked (GlcNAc...) (Potential).
1071N-linked (GlcNAc...) (Potential).
1119GFFKR motif.
Location(AA) Modifications Resource
65N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
89N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
188N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
649N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
670N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
726N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
730N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
862N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
885N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
897N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1060N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1071N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
37Phosphoserine(CDC2)HMM predict
65N-linkedHMM predict
89N-linkedHMM predict
90Phosphotyrosine(INSR)HMM predict
107Phosphoserine(IKK)HMM predict
396Phosphothreonine(MAPK)HMM predict
418Phosphoserine(IKK)HMM predict
562Phosphoserine(ATM)HMM predict
562Phosphoserine(CDC2)HMM predict
566Phosphoserine(ATM)HMM predict
625Phosphoserine(ATM)HMM predict
649N-linkedHMM predict
670N-linkedHMM predict
682Phosphothreonine(PKC)HMM predict
685MethylarginineHMM predict
760Phosphoserine(CK1)HMM predict
786Phosphoserine(CDK)HMM predict
786Phosphoserine(CDC2)HMM predict
796O-linkedHMM predict
806Phosphoserine(CK1)HMM predict
862N-linkedHMM predict
885N-linkedHMM predict
897N-linkedHMM predict
901N-linkedHMM predict
902N-linkedHMM predict
980O-linkedHMM predict
1054Phosphoserine(IKK)HMM predict
1054Phosphoserine(CK1)HMM predict
1060N-linkedHMM predict
1157ProlineHMM predict
1163Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002209
  • Location:chr16 30391571-30442005
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7E 30386601 30386891 290 4826
VDR GM10861-stimGSE22484 30387877 30393553 5676 857
p63 keratinocytesGSE17611 30388113 30388827 714 3102
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 30401323 30401615 292 0
ER E2-MCF7GSE14664 30432124 30432163 39 0
ER Fulvestrant-MCF7GSE14664 30432124 30432156 32 0
Fos K562GSE19551 30410534 30411155 621 0
H3ac HepG2E 30417755 30418166 411 0
Myc K562GSE19551 30410470 30411079 609 0
Oct1 HelaGSE14283 30400748 30400782 34 0
Oct1 HelaGSE14283 30417116 30417153 37 0
Oct1 HelaGSE14283 30432129 30432162 33 0
RNAII Tamoxifen-MCF7GSE14664 30400745 30400782 37 0
RNAII Tamoxifen-MCF7GSE14664 30401837 30401882 45 0
STAT1 IFNSISSRdata 30410581 30411121 540 0
TAF HelaGSE8489 30397549 30398065 516 0
VDR GM10861-stimGSE22484 30439945 30443217 3272 0
p63 keratinocytesGSE17611 30408893 30409705 812 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-126 hsa-mir-126 9 21165896
hsa-miR-126* hsa-mir-126 9 21165896
hsa-miR-148a hsa-mir-148a 7 20483747
hsa-miR-148a* hsa-mir-148a 7 20483747
hsa-miR-21 hsa-mir-21 17 20483747
hsa-miR-21* hsa-mir-21 17 20483747
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
9838 mRNA ITGAL chr16 30391571 30442006 478 mRNA chr16 30399693 30418376Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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