AutismKB 2.0

Annotation Detail for ITGAM


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Basic Information Top
Gene Symbol:ITGAM ( CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6 )
Gene Full Name: integrin, alpha M (complement component 3 receptor 3 subunit)
Band: 16p11.2
Quick LinksEntrez ID:3684; OMIM: 120980; Uniprot ID:ITAM_HUMAN; ENSEMBL ID: ENSG00000169896; HGNC ID: 6149
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
86N-linked (GlcNAc...) (Potential).
240N-linked (GlcNAc...) (Potential).
391N-linked (GlcNAc...) (Potential).
469N-linked (GlcNAc...) (Potential).
692N-linked (GlcNAc...) (Potential).
696N-linked (GlcNAc...) (Potential).
734N-linked (GlcNAc...) (Potential).
801N-linked (GlcNAc...) (Potential).
880N-linked (GlcNAc...) (Potential).
900N-linked (GlcNAc...).
911N-linked (GlcNAc...) (Potential).
940N-linked (GlcNAc...).
946N-linked (GlcNAc...).
978N-linked (GlcNAc...) (Potential).
993N-linked (GlcNAc...) (Potential).
1021N-linked (GlcNAc...) (Potential).
1044N-linked (GlcNAc...) (Potential).
1050N-linked (GlcNAc...) (Potential).
1075N-linked (GlcNAc...) (Potential).
1135GFFKR motif.
Location(AA) Modifications Resource
86N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
240N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
391N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
469N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
692N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
696N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
734N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
801N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
880N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
900N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
911N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
940N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
946N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
978N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
993N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1021N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1044N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1050N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1075N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
96O-linkedHMM predict
98Phosphoserine(IKK)HMM predict
240N-linkedHMM predict
243N-linkedHMM predict
344Phosphoserine(CK2)HMM predict
351Phosphoserine(CK1)HMM predict
391N-linkedHMM predict
439Phosphothreonine(PKC)HMM predict
468O-linkedHMM predict
469N-linkedHMM predict
561O-linkedHMM predict
564Phosphoserine(ATM)HMM predict
564O-linkedHMM predict
568Phosphoserine(ATM)HMM predict
588Phosphoserine(ATM)HMM predict
614Phosphoserine(ATM)HMM predict
661Phosphothreonine(PKC)HMM predict
692N-linkedHMM predict
696N-linkedHMM predict
702Phosphothreonine(PKA)HMM predict
727Phosphoserine(MAPK)HMM predict
734N-linkedHMM predict
740Phosphothreonine(CDK)HMM predict
801N-linkedHMM predict
814Phosphotyrosine(EGFR)HMM predict
849Phosphoserine(IKK)HMM predict
852Phosphoserine(CK1)HMM predict
852O-linkedHMM predict
856O-linkedHMM predict
880N-linkedHMM predict
900N-linkedHMM predict
905N-linkedHMM predict
906N-linkedHMM predict
911N-linkedHMM predict
940N-linkedHMM predict
946N-linkedHMM predict
978N-linkedHMM predict
993N-linkedHMM predict
1021N-linkedHMM predict
1044N-linkedHMM predict
1050N-linkedHMM predict
1075N-linkedHMM predict
1093Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000632
  • Location:chr16 31178788-31251711
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 31163368 31163414 46 15398
Fos K562GSE19551 31172297 31172815 518 6233
Gata2 K562GSE18868 31162811 31163246 435 15760
Oct1 HelaGSE14283 31163362 31163411 49 15402
P300 T30-glioblastomaGSE21026 31172346 31172957 611 6137
STAT1 IFNSISSRdata 31172389 31172860 471 6164
p63 keratinocytesGSE17611 31166878 31167800 922 11450
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF HelaGSE12889 31252600 31252808 208 993
ER E2-MCF7GSE14664 31260849 31260884 35 9155
Oct1 HelaGSE14283 31258595 31258636 41 6904
Oct1 HelaGSE14283 31260850 31260884 34 9156
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 31217898 31218062 164 0
CTCF CD4SISSRdata 31217898 31218062 164 0
NFkBII GM10847GSE19485 31183833 31184909 1076 0
NFkBII GM12878GSE19485 31183676 31185153 1477 0
NFkBII GM12892GSE19485 31183858 31185005 1147 0
NFkBII GM15510GSE19485 31183643 31185047 1404 0
NFkBII GM18526GSE19485 31183826 31184968 1142 0
Oct1 H2O2-HelaGSE14283 31205556 31205587 31 0
Oct1 HelaGSE14283 31199966 31200019 53 0
Oct1 HelaGSE14283 31205542 31205584 42 0
Oct1 HelaGSE14283 31242885 31242926 41 0
P300 T30-glioblastomaGSE21026 31183717 31184799 1082 0
hScc1 BcellGSE12603 31220942 31221151 209 0
hScc1 BcellGSE12603 31249850 31250523 673 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 18158990
hsa-miR-143 hsa-mir-143 5 18158990
hsa-miR-143* hsa-mir-143 5 18158990
hsa-miR-223 hsa-mir-223 X 19059913
hsa-miR-223* hsa-mir-223 X 19059913
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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