AutismKB 2.0

Annotation Detail for ITGB3


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Basic Information Top
Gene Symbol:ITGB3 ( CD61,GP3A,GPIIIa )
Gene Full Name: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Band: 17q21.32
Quick LinksEntrez ID:3690; OMIM: 173470; Uniprot ID:ITB3_HUMAN; ENSEMBL ID: ENSG00000056345; HGNC ID: 6156
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
125N-linked (GlcNAc...).
346N-linked (GlcNAc...) (Potential).
397N-linked (GlcNAc...) (Potential).
478N-linked (GlcNAc...).
585N-linked (GlcNAc...) (Potential).
680N-linked (GlcNAc...).
773Phosphotyrosine.
779Phosphothreonine; by PDPK1 and PKB/AKT1;
785Phosphotyrosine.
Location(AA) Modifications Resource
125N-linked (GlcNAc...).Swiss-Prot 53.0
346N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
397N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
478N-linked (GlcNAc...).Swiss-Prot 53.0
585N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
680N-linked (GlcNAc...).Swiss-Prot 53.0
773Phosphotyrosine (Syk;Src)Phospho.ELM 6.0
773Phosphotyrosine.Swiss-Prot 53.0
777Phosphothreonine (PDK-1)Phospho.ELM 6.0
779Phosphothreonine; by PDPK1 and PKB/AKT1;in vitro.Swiss-Prot 53.0
779Phosphothreonine (PDK-1)Phospho.ELM 6.0
785Phosphotyrosine.Swiss-Prot 53.0
785Phosphotyrosine (Syk;Src)Phospho.ELM 6.0
Location(AA) Modification Resource
37Phosphoserine(IKK)HMM predict
100Phosphoserine(IKK)HMM predict
104Phosphoserine(ATM)HMM predict
104Phosphoserine(IKK)HMM predict
110Phosphoserine(CDC2)HMM predict
141SulfotyrosineHMM predict
166Phosphothreonine(PKC)HMM predict
172Phosphothreonine(PKA)HMM predict
312O-linkedHMM predict
326Phosphoserine(ATM)HMM predict
397N-linkedHMM predict
402N-linkedHMM predict
403N-linkedHMM predict
441Phosphothreonine(PKC)HMM predict
478N-linkedHMM predict
488S-palmitoylHMM predict
504Phosphotyrosine(Syk)HMM predict
507Phosphoserine(ATM)HMM predict
513Phosphoserine(ATM)HMM predict
585N-linkedHMM predict
630S-palmitoylHMM predict
680N-linkedHMM predict
685N-linkedHMM predict
696Phosphotyrosine(EGFR)HMM predict
696Phosphotyrosine(Syk)HMM predict
779O-linkedHMM predict
782N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000212
  • Location:chr17 42686206-42745074
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 42672029 42673455 1426 13465
P300 T30-glioblastomaGSE21026 42671959 42673325 1366 13565
TFAP2C MCF7GSE21234 42684504 42685013 509 1448
USF1 HepG2E 42684538 42685735 1197 1070
USF2 HepG2E 42684538 42685505 967 1185
p130 SenescentGSE19898 42672108 42672802 694 13752
p130 shRbSenescentGSE19898 42672105 42672516 411 13896
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 42747556 42748506 950 2957
CTCF CD4GSE12889 42748000 42748440 440 3146
CTCF CD4SISSRdata 42748000 42748440 440 3146
Myc K562GSE19551 42747985 42748327 342 3082
P300 T30-glioblastomaGSE21026 42747458 42749041 1583 3175
hScc1 BcellGSE12603 42747944 42748395 451 3095
hScc1 CdLSGSE12603 42747944 42748429 485 3112
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 42710972 42713541 2569 0
CBP T30-glioblastomaGSE21026 42737409 42738572 1163 0
CTCF CD4GSE12889 42686195 42686356 161 0
CTCF CD4SISSRdata 42686195 42686356 161 0
CTCF G2GSE9613 42685976 42686620 644 0
Fos K562GSE19551 42698196 42698774 578 0
Myc K562GSE19551 42698230 42698698 468 0
Oct1 H2O2-HelaGSE14283 42695685 42695712 27 0
Oct1 H2O2-HelaGSE14283 42715878 42715912 34 0
Oct1 HelaGSE14283 42695684 42695717 33 0
Oct1 HelaGSE14283 42699598 42699631 33 0
Oct1 HelaGSE14283 42711506 42711533 27 0
Oct1 HelaGSE14283 42715885 42715914 29 0
Oct1 HelaGSE14283 42731227 42731265 38 0
P300 T0-glioblastomaGSE21026 42737618 42738720 1102 0
P300 T30-glioblastomaGSE21026 42737291 42738709 1418 0
RARG MCF7GSE15244 42737603 42738190 587 0
RNAII Tamoxifen-MCF7GSE14664 42695683 42695719 36 0
hScc1 CdLSGSE12603 42711328 42712022 694 0
hScc1 CdLSGSE12603 42718516 42719871 1355 0
p130 QuiescentGSE19898 42738045 42738333 288 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 18679415
hsa-let-7a hsa-let-7a-2 11 18679415
hsa-let-7a hsa-let-7a-3 22 18679415
hsa-let-7a hsa-let-7a-1 9 20498642
hsa-let-7a hsa-let-7a-2 11 20498642
hsa-let-7a hsa-let-7a-3 22 20498642
hsa-let-7a* hsa-let-7a-1 9 20498642
hsa-let-7a* hsa-let-7a-3 22 20498642
hsa-let-7b hsa-let-7b 22 20498642
hsa-let-7b* hsa-let-7b 22 20498642
hsa-let-7c hsa-let-7c 21 20498642
hsa-let-7c* hsa-let-7c 21 20498642
hsa-let-7d hsa-let-7d 9 20498642
hsa-let-7d* hsa-let-7d 9 20498642
hsa-let-7e hsa-let-7e 19 20498642
hsa-let-7e* hsa-let-7e 19 20498642
hsa-let-7f hsa-let-7f-1 9 20498642
hsa-let-7f hsa-let-7f-2 X 20498642
hsa-let-7f-1* hsa-let-7f-1 9 20498642
hsa-let-7f-2* hsa-let-7f-2 X 20498642
hsa-let-7g hsa-let-7g 3 20498642
hsa-let-7g* hsa-let-7g 3 20498642
hsa-let-7i hsa-let-7i 12 20498642
hsa-let-7i* hsa-let-7i 12 20498642
hsa-miR-30a hsa-mir-30a 6 20498642
hsa-miR-30a* hsa-mir-30a 6 20498642
hsa-miR-30b hsa-mir-30b 8 20498642
hsa-miR-30b* hsa-mir-30b 8 20498642
hsa-miR-30c hsa-mir-30c-2 6 20498642
hsa-miR-30c hsa-mir-30c-1 1 20498642
hsa-miR-30c-1* hsa-mir-30c-1 1 20498642
hsa-miR-30c-2* hsa-mir-30c-2 6 20498642
hsa-miR-30d hsa-mir-30d 8 20498642
hsa-miR-30d* hsa-mir-30d 8 20498642
hsa-miR-30e hsa-mir-30e 1 20498642
hsa-miR-30e* hsa-mir-30e 1 20498642
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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