AutismKB 2.0

Annotation Detail for ITK


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Basic Information Top
Gene Symbol:ITK ( EMT,LYK,MGC126257,MGC126258,PSCTK2 )
Gene Full Name: IL2-inducible T-cell kinase
Band: 5q33.3
Quick LinksEntrez ID:3702; OMIM: 186973; Uniprot ID:ITK_HUMAN; ENSEMBL ID: ENSG00000113263; HGNC ID: 6171
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
180Phosphotyrosine; by autocatalysis.
296N6-acetyllysine.
512Phosphotyrosine; by autocatalysis.
565Phosphoserine.
Location(AA) Modifications Resource
180Phosphotyrosine (Tec;BTK;ITK)Phospho.ELM 6.0
512Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
512Phosphotyrosine (Lck)Phospho.ELM 6.0
565Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
21Phosphothreonine(PKA)HMM predict
22Phosphoserine(PKB)HMM predict
22Phosphoserine(PKG)HMM predict
22Phosphoserine(CAMK2)HMM predict
50Phosphothreonine(PKC)HMM predict
50Phosphothreonine(PKA)HMM predict
151N-linkedHMM predict
160Phosphothreonine(CDK)HMM predict
160Phosphothreonine(CDC2)HMM predict
182SulfotyrosineHMM predict
220Phosphotyrosine(INSR)HMM predict
241N-linkedHMM predict
392Phosphothreonine(PKC)HMM predict
514Phosphoserine(CDC2)HMM predict
516O-linkedHMM predict
536Phosphoserine(CK2)HMM predict
561N-linkedHMM predict
564N-linkedHMM predict
588Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005546
  • Location:chr5 156540484-156614686
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 156612320 156613361 1041 0
Fos K562GSE19551 156593012 156593431 419 0
Nanog hESGSE18292 156547003 156547294 291 0
STAT1 HeLaGSE12782 156581616 156582875 1259 0
STAT1 HeLaGSE12783 156581690 156582875 1185 0
STAT1 IFNSISSRdata 156581778 156582653 875 0
Sox2 hESGSE18292 156546989 156547308 319 0
Sox2 hESGSE18292 156613215 156613366 151 0
hScc1 BcellGSE12603 156612172 156613425 1253 0
hScc1 CdLSGSE12603 156612543 156613752 1209 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-192 hsa-mir-192 11 18805502
hsa-miR-192* hsa-mir-192 11 18805502
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
21732 mRNA ITK chr5 156540484 156614687 25031 EST chr5 156558937 156583968 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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