AutismKB 2.0

Annotation Detail for ITPKB


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Basic Information Top
Gene Symbol:ITPKB ( IP3-3KB,IP3K,IP3K-B,IP3KB,PIG37 )
Gene Full Name: inositol 1,4,5-trisphosphate 3-kinase B
Band: 1q42.12
Quick LinksEntrez ID:3707; OMIM: 147522; Uniprot ID:IP3KB_HUMAN; ENSEMBL ID: ENSG00000143772; HGNC ID: 6179
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
43Phosphoserine.
49Phosphoserine.
65Phosphoserine.
71Phosphoserine.
174Phosphoserine.
176Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
29O-linkedHMM predict
31O-linkedHMM predict
33Phosphothreonine(CDC2)HMM predict
33Phosphothreonine(MAPK)HMM predict
33Phosphothreonine(CDK)HMM predict
43Phosphoserine(MAPK)HMM predict
49Phosphoserine(CDC2)HMM predict
65Phosphoserine(IKK)HMM predict
65Phosphoserine(ATM)HMM predict
65Phosphoserine(CDC2)HMM predict
83N-linkedHMM predict
84Phosphoserine(IKK)HMM predict
86Phosphoserine(CK1)HMM predict
86Phosphoserine(CK2)HMM predict
88Phosphoserine(IKK)HMM predict
88Phosphoserine(CK1)HMM predict
95O-linkedHMM predict
95Phosphoserine(IKK)HMM predict
96Phosphoserine(IKK)HMM predict
99Phosphoserine(CDC2)HMM predict
120Phosphoserine(IKK)HMM predict
120Phosphoserine(ATM)HMM predict
120Phosphoserine(CDC2)HMM predict
171MethylarginineHMM predict
174Phosphoserine(IKK)HMM predict
174Phosphoserine(PKB)HMM predict
176Phosphoserine(PKB)HMM predict
183Phosphoserine(CDK)HMM predict
183O-linkedHMM predict
184O-linkedHMM predict
184Phosphoserine(ATM)HMM predict
202Phosphothreonine(PKC)HMM predict
204Phosphoserine(PKB)HMM predict
204Phosphoserine(CAMK2)HMM predict
204Phosphoserine(IKK)HMM predict
224Phosphoserine(IKK)HMM predict
246O-linkedHMM predict
264O-linkedHMM predict
269Phosphoserine(CDC2)HMM predict
269PhosphoserineHMM predict
269Phosphoserine(IKK)HMM predict
280Phosphoserine(CDC2)HMM predict
282Phosphothreonine(MAPK)HMM predict
287Phosphoserine(IKK)HMM predict
312O-linkedHMM predict
364MethylarginineHMM predict
384Phosphoserine(ATM)HMM predict
402O-linkedHMM predict
405Phosphoserine(CK1)HMM predict
408Phosphoserine(CK1)HMM predict
428O-linkedHMM predict
456Phosphoserine(CDC2)HMM predict
544Phosphoserine(MAPK)HMM predict
588Phosphoserine(CDC2)HMM predict
599Phosphoserine(PKG)HMM predict
601O-linkedHMM predict
606O-linkedHMM predict
610Phosphoserine(CK2)HMM predict
612Phosphotyrosine(EGFR)HMM predict
615PhosphoserineHMM predict
615Phosphoserine(CK1)HMM predict
621Phosphoserine(CK1)HMM predict
726Phosphotyrosine(INSR)HMM predict
738Phosphoserine(IKK)HMM predict
764Phosphoserine(PKC)HMM predict
770Phosphotyrosine(EGFR)HMM predict
792Phosphothreonine(PKC)HMM predict
902Phosphothreonine(MAPK)HMM predict
931AsparagineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002221
  • Location:chr1 224886014-224991817
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 224992327 224992633 306 663
CTCF G2GSE9613 224992882 224993237 355 1242
CTCF G2GSE9613 225007916 225008583 667 16432
hScc1 BcellGSE12603 224991330 224993560 2230 628
hScc1 CdLSGSE12603 224990987 224992980 1993 166
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 224880813 224881062 249 5077
CTCF CD4SISSRdata 224880813 224881062 249 5077
CTCF G2GSE9613 224880277 224881304 1027 5224
Myc K562GSE19551 224880743 224881163 420 5062
hScc1 BcellGSE12603 224880003 224881304 1301 5361
hScc1 BcellGSE12603 224882527 224882705 178 3399
hScc1 CdLSGSE12603 224880770 224881304 534 4978
hScc1 G2GSE9613 224880314 224881304 990 5206
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 224916819 224918034 1215 0
CTCF CD4GSE12889 224888390 224888815 425 0
CTCF CD4GSE12889 224898604 224898948 344 0
CTCF CD4SISSRdata 224888390 224888815 425 0
CTCF CD4SISSRdata 224898604 224898948 344 0
CTCF HelaGSE12889 224888518 224888902 384 0
CTCF G2GSE9613 224888157 224889459 1302 0
CTCF G2GSE9613 224891653 224891895 242 0
CTCF G2GSE9613 224896574 224897019 445 0
CTCF G2GSE9613 224897506 224897719 213 0
CTCF G2GSE9613 224900204 224900637 433 0
CTCF G2GSE9613 224901377 224901701 324 0
CTCF G2GSE9613 224904233 224904804 571 0
CTCF G2GSE9613 224906606 224906857 251 0
CTCF G2GSE9613 224913590 224913845 255 0
CTCF G2GSE9613 224957705 224957965 260 0
CTCF G2GSE9613 224965484 224966123 639 0
ER MCF7GSE19013 224965686 224966210 524 0
ETS1 JurkatGSE17954 224957508 224958398 890 0
FOXA1 MCF7GSE15244 224925458 224926414 956 0
FOXA1 MCF7GSE15244 224956753 224957582 829 0
Fos K562GSE19551 224897377 224897841 464 0
FoxA1 MCF7MACSdata 224957237 224957495 258 0
Myc hESGSE17917 224957906 224958215 309 0
NRSF JurkatSISSRdata 224957829 224958014 185 0
Nanog hESGSE18292 224934578 224934863 285 0
Nanog hESGSE18292 224965570 224965765 195 0
P300 T30-glioblastomaGSE21026 224916749 224917997 1248 0
PHF8 293TGSE20725 224957122 224958516 1394 0
PHF8 HeLaGSE20725 224957338 224958243 905 0
RARA MCF7GSE15244 224956753 224957498 745 0
RARG MCF7GSE15244 224956753 224957413 660 0
TFAP2C MCF7GSE21234 224925475 224926146 671 0
TFAP2C MCF7GSE21234 224951972 224952809 837 0
TFAP2C MCF7GSE21234 224977817 224978438 621 0
USF1 HepG2E 224956753 224957083 330 0
hScc1 BcellGSE12603 224887646 224889277 1631 0
hScc1 BcellGSE12603 224890642 224891035 393 0
hScc1 BcellGSE12603 224897579 224897910 331 0
hScc1 BcellGSE12603 224898691 224899155 464 0
hScc1 BcellGSE12603 224900382 224901592 1210 0
hScc1 BcellGSE12603 224929239 224929490 251 0
hScc1 BcellGSE12603 224934294 224934544 250 0
hScc1 BcellGSE12603 224957677 224958192 515 0
hScc1 BcellGSE12603 224965412 224966696 1284 0
hScc1 CdLSGSE12603 224888302 224889199 897 0
hScc1 CdLSGSE12603 224904233 224904732 499 0
hScc1 CdLSGSE12603 224965367 224965929 562 0
hScc1 G2GSE9613 224888266 224889459 1193 0
p130 SenescentGSE19898 224903695 224903943 248 0
p130 shRbQuiescentGSE19898 224918664 224919451 787 0
p63 keratinocytesGSE17611 224950992 224951975 983 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
2432 EST chr1 223162781 223170741 7960 mRNA ITPKB chr1 223126126 223231930 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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