AutismKB 2.0

Annotation Detail for KCNA4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KCNA4 ( HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,PCN2 )
Gene Full Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Band: 11p14.1
Quick LinksEntrez ID:3739; OMIM: 176266; Uniprot ID:KCNA4_HUMAN; ENSEMBL ID: ENSG00000182255; HGNC ID: 6222
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
90Phosphoserine; by PKA (Potential).
122Phosphoserine (By similarity).
181N-linked (GlcNAc...) (Potential).
352N-linked (GlcNAc...) (Potential).
529Selectivity filter (By similarity).
599Phosphoserine; by PKA (Potential).
653PDZ-binding (By similarity).
Location(AA) Modifications Resource
90Phosphoserine (by PKA) (Potential).Swiss-Prot 53.0
122Phosphoserine (By similarity).Swiss-Prot 53.0
181N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
352N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
599Phosphoserine (by PKA) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
11Phosphoserine(IKK)HMM predict
54O-linkedHMM predict
57O-linkedHMM predict
82PhosphoserineHMM predict
88Phosphothreonine(CK2)HMM predict
122Phosphoserine(CK1)HMM predict
122Phosphoserine(CK2)HMM predict
141SulfotyrosineHMM predict
142SulfotyrosineHMM predict
143Phosphoserine(CK2)HMM predict
153SulfotyrosineHMM predict
166Phosphotyrosine(Jak)HMM predict
166Phosphotyrosine(INSR)HMM predict
181N-linkedHMM predict
352N-linkedHMM predict
393S-palmitoylHMM predict
461Phosphoserine(CK1)HMM predict
588Phosphotyrosine(Jak)HMM predict
600Phosphoserine(CK2)HMM predict
600Phosphoserine(PKA)HMM predict
601Phosphothreonine(PKC)HMM predict
603Phosphoserine(CK1)HMM predict
611Phosphotyrosine(EGFR)HMM predict
611Phosphotyrosine(Syk)HMM predict
611Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002233
  • Location:chr11 29988341-29995063
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog ESGSE20650 30003445 30004437 992 8878
Nanog ESGSE20650 30012321 30012659 338 17427
Nanog hESGSE18292 30003473 30004478 1005 8912
Oct1 HelaGSE14283 30006297 30006330 33 11250
Oct4 ESGSE20650 30003544 30003913 369 8665
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 29979838 29979866 28 8490
No data
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018