AutismKB 2.0

Annotation Detail for AGRN


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Basic Information Top
Gene Symbol:AGRN ( FLJ45064 )
Gene Full Name: agrin
Band: 1p36.33
Quick LinksEntrez ID:375790; OMIM: 103320; Uniprot ID:AGRIN_HUMAN; ENSEMBL ID: ENSG00000188157; HGNC ID: 329
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
135N-linked (GlcNAc...).
250N-linked (GlcNAc...) (Potential).
777N-linked (GlcNAc...) (Potential).
932N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
135N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
250N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
777N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
932N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
135N-linkedHMM predict
167Phosphothreonine(CDK)HMM predict
167Phosphothreonine(MAPK)HMM predict
200Phosphoserine(CDC2)HMM predict
212Phosphoserine(IKK)HMM predict
250N-linkedHMM predict
614O-linkedHMM predict
620S-palmitoylHMM predict
711Phosphoserine(IKK)HMM predict
777N-linkedHMM predict
791Phosphoserine(IKK)HMM predict
896O-linkedHMM predict
896Phosphoserine(IKK)HMM predict
932N-linkedHMM predict
976O-linkedHMM predict
980O-linkedHMM predict
981O-linkedHMM predict
981O-linkedHMM predict
983O-linkedHMM predict
985O-linkedHMM predict
987O-linkedHMM predict
994Phosphoserine(ATM)HMM predict
1010O-linkedHMM predict
1010O-linkedHMM predict
1014Phosphoserine(ATM)HMM predict
1014Phosphoserine(IKK)HMM predict
1017PhosphothreonineHMM predict
1017O-linkedHMM predict
1017O-linkedHMM predict
1021O-linkedHMM predict
1022O-linkedHMM predict
1022O-linkedHMM predict
1026Phosphothreonine(PKC)HMM predict
1027O-linkedHMM predict
1034O-linkedHMM predict
1034O-linkedHMM predict
1047Phosphoserine(CDC2)HMM predict
1047PhosphoserineHMM predict
1047Phosphoserine(CDK)HMM predict
1047O-linkedHMM predict
1051O-linkedHMM predict
1062Phosphoserine(IKK)HMM predict
1066Phosphoserine(CK2)HMM predict
1072Phosphoserine(CK1)HMM predict
1078O-linkedHMM predict
1092O-linkedHMM predict
1095O-linkedHMM predict
1150SulfotyrosineHMM predict
1171Phosphoserine(CK2)HMM predict
1230O-linkedHMM predict
1234Phosphoserine(PKG)HMM predict
1270O-linkedHMM predict
1274Phosphothreonine(PKC)HMM predict
1275Phosphothreonine(PKC)HMM predict
1277O-linkedHMM predict
1281O-linkedHMM predict
1282O-linkedHMM predict
1285Phosphothreonine(CDC2)HMM predict
1285Phosphothreonine(MAPK)HMM predict
1292O-linkedHMM predict
1292O-linkedHMM predict
1301O-linkedHMM predict
1306Phosphothreonine(PKC)HMM predict
1307Phosphothreonine(PKC)HMM predict
1316O-linkedHMM predict
1445O-linkedHMM predict
1467Phosphothreonine(PKA)HMM predict
1469Phosphoserine(CAMK2)HMM predict
1480Phosphoserine(CDC2)HMM predict
1590Phosphoserine(IKK)HMM predict
1622PhosphothreonineHMM predict
1800Phosphothreonine(MAPK)HMM predict
1949Phosphothreonine(PKC)HMM predict
1977O-linkedHMM predict
1978Phosphoserine(CDC2)HMM predict
1978O-linkedHMM predict
2045ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_198576
  • Location:chr1 945365-981354
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 944615 944778 163 669
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 988932 989926 994 8075
CTCF CD4GSE12889 989028 989369 341 7844
CTCF CD4SISSRdata 989028 989369 341 7844
CTCF G2GSE9613 986533 987168 635 5496
CTCF G2GSE9613 989054 989464 410 7905
CTCF G2GSE9613 991860 992030 170 10591
CTCF G2GSE9613 992568 993382 814 11621
Fos K562GSE19551 989285 989979 694 8278
P300 T30-glioblastomaGSE21026 988960 990027 1067 8139
Rb shRbSenescenceGSE19898 985080 985292 212 3832
TFAP2C MCF7GSE21234 982005 982420 415 858
hScc1 BcellGSE12603 987635 987921 286 6424
hScc1 BcellGSE12603 988804 989586 782 7841
p130 SenescentGSE19898 989472 989683 211 8223
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 958128 958501 373 0
CTCF CD4GSE12889 965971 966142 171 0
CTCF CD4SISSRdata 958128 958501 373 0
CTCF CD4SISSRdata 965971 966142 171 0
CTCF JurkatGSE12889 958254 958497 243 0
RUNX JurkatGSE17954 955476 955635 159 0
Rb SenescentGSE19898 945475 945716 241 0
TFAP2C MCF7GSE21234 946272 947179 907 0
TFAP2C MCF7GSE21234 949890 950193 303 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1124 Unknown pSILAC miR-1 AGRN down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000188157 n_a n_a n_a n_a n_a
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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