AutismKB 2.0

Annotation Detail for KCNJ6


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Basic Information Top
Gene Symbol:KCNJ6 ( BIR1,GIRK-2,GIRK2,KATP-2,KATP2,KCNJ7,KIR3.2,MGC126596,hiGIRK2 )
Gene Full Name: potassium inwardly-rectifying channel, subfamily J, member 6
Band: 21q22.13
Quick LinksEntrez ID:3763; OMIM: 600877; Uniprot ID:IRK6_HUMAN; ENSEMBL ID: ENSG00000157542; HGNC ID: 6267
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
157Selectivity filter (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
49Phosphothreonine(PKC)HMM predict
130PhosphothreonineHMM predict
194Phosphoserine(PKG)HMM predict
194Phosphoserine(ATM)HMM predict
202Phosphothreonine(PKA)HMM predict
202Phosphothreonine(PKC)HMM predict
247Phosphothreonine(CK2)HMM predict
256N-linkedHMM predict
261N-linkedHMM predict
347Phosphotyrosine(Syk)HMM predict
360O-linkedHMM predict
362O-linkedHMM predict
384Phosphoserine(IKK)HMM predict
397Phosphothreonine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002240
  • Location:chr21 37918656-38210565
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 38211210 38212081 871 1080
Nanog hESGSE18292 38215137 38215485 348 4746
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TFAP2C MCF7GSE21234 37913673 37914128 455 4756
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 38143770 38144535 765 0
CTCF CD4GSE12889 37936793 37936994 201 0
CTCF CD4GSE12889 37969463 37969684 221 0
CTCF CD4GSE12889 37994891 37995094 203 0
CTCF CD4GSE12889 38006449 38006594 145 0
CTCF CD4SISSRdata 37936793 37936994 201 0
CTCF CD4SISSRdata 37969463 37969684 221 0
CTCF CD4SISSRdata 37994891 37995094 203 0
CTCF CD4SISSRdata 38006449 38006594 145 0
CTCF HelaGSE12889 38053123 38053498 375 0
CTCF JurkatGSE12889 37969481 37969763 282 0
CTCF JurkatGSE12889 38053244 38053502 258 0
CTCF G2GSE9613 37936557 37936886 329 0
CTCF G2GSE9613 37969297 37969794 497 0
CTCF G2GSE9613 37970317 37971078 761 0
CTCF G2GSE9613 37994827 37995429 602 0
ER Breast-CancerGSE22609 38062032 38062798 766 0
ER MCF7GSE19013 38062141 38062794 653 0
FOXA1 MCF7GSE15244 37998061 37998765 704 0
FOXA1 MCF7GSE15244 38004652 38005217 565 0
FOXA1 MCF7GSE15244 38136303 38136964 661 0
FOXA1 MCF7GSE15244 38139608 38140224 616 0
FoxA1 MCF7MACSdata 37930746 37930937 191 0
H3K27me3 colorectalcancer 38208023 38208387 364 0
H3K27me3 colorectalcancer 38209319 38210120 801 0
Myc K562GSE19551 37994813 37995235 422 0
NFkBII GM10847GSE19485 37925505 37926619 1114 0
NFkBII GM12878GSE19485 37924909 37927190 2281 0
NFkBII GM12892GSE19485 37925189 37926831 1642 0
NFkBII GM15510GSE19485 37925496 37926633 1137 0
NFkBII GM18526GSE19485 37925420 37926690 1270 0
NRSF JurkatGSE13047 38207985 38209088 1103 0
NRSF JurkatSISSRdata 38208115 38208723 608 0
NRSF mAbJurkat 38206026 38207672 1646 0
NRSF mAbJurkat 38208023 38210045 2022 0
NRSF-mono JurkatQuESTdata 38207990 38208858 868 0
NRSF-poly JurkatQuESTdata 38208175 38209028 853 0
Nanog ESGSE20650 37925849 37926446 597 0
Nanog hESGSE18292 37962926 37963304 378 0
P300 T30-glioblastomaGSE21026 37930392 37931279 887 0
P300 T30-glioblastomaGSE21026 37952919 37954314 1395 0
P300 T30-glioblastomaGSE21026 38143826 38144373 547 0
RARA MCF7GSE15244 38062238 38062649 411 0
RARG MCF7GSE15244 38062057 38062649 592 0
Rb QuiescentGSE19898 38093450 38093592 142 0
Sox2 hESGSE18292 38113634 38114104 470 0
Stat6 IL-4-hr4GSE17850 38124184 38124799 615 0
TFAP2C MCF7GSE21234 37930753 37931005 252 0
TFAP2C MCF7GSE21234 38004614 38005204 590 0
TFAP2C MCF7GSE21234 38059295 38059748 453 0
TFAP2C MCF7GSE21234 38062230 38062699 469 0
hScc1 BcellGSE12603 37936693 37936922 229 0
hScc1 BcellGSE12603 37969221 37969832 611 0
hScc1 BcellGSE12603 38053294 38053876 582 0
hScc1 BcellGSE12603 38209748 38210182 434 0
hScc1 CdLSGSE12603 37936425 37937281 856 0
hScc1 CdLSGSE12603 37969297 37969942 645 0
hScc1 CdLSGSE12603 38006195 38006588 393 0
p130 QuiescentGSE19898 38075133 38075281 148 0
p63 keratinocytesGSE17611 37941545 37942668 1123 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
16937 mRNA chr21 37981056 37981752 696 mRNA KCNJ6 chr21 37918656 38210566 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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