AutismKB 2.0

Annotation Detail for KCNN4


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Basic Information Top
Gene Symbol:KCNN4 ( IK1,IKCA1,KCA4,KCa3.1,SK4,hIKCa1,hKCa4,hSK4 )
Gene Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Band: 19q13.31
Quick LinksEntrez ID:3783; OMIM: 602754; Uniprot ID:KCNN4_HUMAN; ENSEMBL ID: ENSG00000104783; HGNC ID: 6293
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
358Phosphohistidine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
137O-linkedHMM predict
176N-linkedHMM predict
232N-linkedHMM predict
276S-palmitoylHMM predict
277S-palmitoylHMM predict
307SulfotyrosineHMM predict
314Phosphoserine(PKG)HMM predict
329Phosphothreonine(PKC)HMM predict
334Phosphoserine(PKG)HMM predict
384N-linkedHMM predict
387Phosphoserine(CK1)HMM predict
420ProlineHMM predict
423Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002250
  • Location:chr19 48962526-48977248
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 48981312 48981657 345 4236
CTCF CD4SISSRdata 48981312 48981657 345 4236
CTCF G2GSE9613 48978531 48979279 748 1657
CTCF G2GSE9613 48981166 48981476 310 4073
Fos K562GSE19551 48980253 48980865 612 3311
GABP k562GSE8489 48977294 48978853 1559 825
H3K4me2 HCT116GSE10453 48977222 48978821 1599 773
NRSF mAbJurkat 48977978 48979279 1301 1380
NRSF mAbJurkat 48983645 48983973 328 6561
Rb QuiescentGSE19898 48980565 48980702 137 3385
SRF k562GSE8489 48977368 48978786 1418 829
TAF HelaGSE8489 48977258 48978821 1563 791
TAF k562GSE8489 48977222 48978888 1666 807
TFAP2C MCF7GSE21234 48980255 48981681 1426 3720
hScc1 BcellGSE12603 48981139 48981694 555 4168
hScc1 CdLSGSE12603 48981139 48981694 555 4168
p130 SenescentGSE19898 48980391 48980850 459 3372
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 48961206 48961604 398 1122
CBP T30-glioblastomaGSE21026 48960922 48961955 1033 1088
NFkBII GM10847GSE19485 48959081 48960222 1141 2875
NFkBII GM12878GSE19485 48958758 48960498 1740 2899
NFkBII GM12878GSE19485 48960730 48962918 2188 703
NFkBII GM12892GSE19485 48958828 48960528 1700 2849
NFkBII GM12892GSE19485 48960692 48963203 2511 579
NFkBII GM15510GSE19485 48958951 48960258 1307 2922
NFkBII GM18526GSE19485 48958870 48960508 1638 2838
P300 T30-glioblastomaGSE21026 48960938 48961974 1036 1071
Rb GrowingGSE19898 48961288 48961538 250 1114
Rb QuiescentGSE19898 48961079 48961514 435 1230
Rb SenescentGSE19898 48961245 48961583 338 1113
Rb shRbQuiescentGSE19898 48961305 48961551 246 1099
Rb shRbSenescenceGSE19898 48961289 48961446 157 1159
TFAP2C MCF7GSE21234 48961086 48961747 661 1110
VDR GM10855-stimGSE22484 48958594 48963340 4746 1560
VDR GM10861-stimGSE22484 48958456 48963254 4798 1672
p130 QuiescentGSE19898 48961285 48961516 231 1126
p130 SenescentGSE19898 48955577 48955895 318 6791
p130 SenescentGSE19898 48961140 48961598 458 1158
p130 shRbQuiescentGSE19898 48961223 48961676 453 1077
p130 shRbSenescentGSE19898 48961186 48961745 559 1061
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 48962507 48962753 246 0
CTCF CD4SISSRdata 48962507 48962753 246 0
CTCF G2GSE9613 48962360 48963255 895 0
CTCF G2GSE9613 48970214 48970899 685 0
ER Fulvestrant-MCF7GSE14664 48966204 48966279 75 0
Gata1 K562GSE18868 48970240 48971093 853 0
Gata2 K562GSE18868 48969736 48971124 1388 0
Pol2 GM12878GSE19551 48976646 48977849 1203 0
Rb SenescentGSE19898 48970546 48970848 302 0
TFAP2C MCF7GSE21234 48972111 48972711 600 0
TFAP2C MCF7GSE21234 48976582 48977494 912 0
hScc1 BcellGSE12603 48962360 48963079 719 0
hScc1 BcellGSE12603 48970251 48970824 573 0
hScc1 BcellGSE12603 48975191 48975484 293 0
hScc1 BcellGSE12603 48976695 48976898 203 0
hScc1 CdLSGSE12603 48962360 48962861 501 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1062 Unknown pSILAC miR-16 KCNN4 down >75% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000104783 n_a n_a n_a "lymphocyte, leukocyte" "tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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