Annotation Detail for KCNQ1
Basic Information Top
| Gene Symbol: | KCNQ1 ( ATFB1,ATFB3,FLJ26167,JLNS1,KCNA8,KCNA9,KVLQT1,Kv1.9,Kv7.1,LQT,LQT1,RWS,SQT2,WRS ) |
|---|---|
| Gene Full Name: | potassium voltage-gated channel, KQT-like subfamily, member 1 |
| Band: | 11p15.5-p15.4 |
| Quick Links | Entrez ID:3784; OMIM: 607542; Uniprot ID:KCNQ1_HUMAN; ENSEMBL ID: ENSG00000053918; HGNC ID: 6294 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 289 | N-linked (GlcNAc...) (Potential). | |
| 317 | Selectivity filter (By similarity). | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 289 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 6 | Phosphoserine | HMM predict |
| 6 | Phosphoserine(CDC2) | HMM predict |
| 51 | Phosphotyrosine(INSR) | HMM predict |
| 66 | O-linked | HMM predict |
| 66 | O-linked | HMM predict |
| 66 | Phosphoserine(MAPK) | HMM predict |
| 66 | Phosphoserine(CDC2) | HMM predict |
| 289 | N-linked | HMM predict |
| 322 | Phosphothreonine | HMM predict |
| 407 | Phosphoserine(CDC2) | HMM predict |
| 407 | Phosphoserine(MAPK) | HMM predict |
| 409 | Phosphoserine(CDC2) | HMM predict |
| 409 | Phosphoserine(MAPK) | HMM predict |
| 409 | Phosphoserine(CDK) | HMM predict |
| 409 | Phosphoserine(ATM) | HMM predict |
| 432 | Phosphothreonine(MAPK) | HMM predict |
| 439 | Phosphothreonine(PKC) | HMM predict |
| 468 | Phosphoserine(CDK) | HMM predict |
| 484 | Phosphoserine(IKK) | HMM predict |
| 536 | Phosphotyrosine(Syk) | HMM predict |
| 627 | O-linked | HMM predict |
| 632 | Methylarginine | HMM predict |
| 644 | O-linked | HMM predict |
| 672 | Proline | HMM predict |
- RefSeq ID: NM_000218
- Location:chr11 2422796-2826914
- strand:+
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| NRSF | pAb | Jurkat | 2414805 | 2415683 | 878 | 7553 |
| hScc1 | Bcell | GSE12603 | 2418142 | 2418527 | 385 | 4462 |
| No data |
| No data |
| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-miR-1 | hsa-mir-1-2 | 18 | 17443681 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 17443681 |
| hsa-miR-1 | hsa-mir-1-2 | 18 | 17443681 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 17443681 |
| hsa-miR-1 | hsa-mir-1-2 | 18 | 17443681 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 17443681 |
| hsa-miR-1 | hsa-mir-1-2 | 18 | 17443681 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 17443681 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 18711016 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 18711016 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 17443681 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 17443681 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 18711016 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 18711016 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 17443681 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 17443681 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 18711016 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 18711016 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 17443681 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 17443681 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 18711016 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 18711016 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 17443681 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 17443681 |
| hsa-miR-133b | hsa-mir-133b | 6 | 18711016 |
| hsa-miR-133b | hsa-mir-133b | 6 | 17443681 |
| hsa-miR-133b | hsa-mir-133b | 6 | 18711016 |
| hsa-miR-133b | hsa-mir-133b | 6 | 17443681 |
| hsa-miR-133b | hsa-mir-133b | 6 | 18711016 |
| hsa-miR-133b | hsa-mir-133b | 6 | 17443681 |
| hsa-miR-133b | hsa-mir-133b | 6 | 18711016 |
| hsa-miR-133b | hsa-mir-133b | 6 | 17443681 |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 220 | mRNA repression | TRUE | miR-1 | KCNQ1 | Luciferase assay | 17443681 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000053918 | "cardiac and skeletal muscles, cardiogenesis" | n_a | n_a | "lymphocyte, muscle cell" | "benign tumour, malignant tumour, carcinoma, sarcoma, leukaemia" |
| Cluster ID | Plue Type | Plus Gene Name | Plus Chromosome | Plus Start | Plus End | Overlap Length | Minus Type | Minus Gene Name | Minus Chromosome | Minus Star | Minus End | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3980 | mRNA | KCNQ1 | chr11 | 2422796 | 2826915 | 444 | mRNA | chr11 | 2546396 | 2552769 | Sense/Antisense (SA) pairs | |