AutismKB 2.0

Annotation Detail for KDR


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Basic Information Top
Gene Symbol:KDR ( CD309,FLK1,VEGFR,VEGFR2 )
Gene Full Name: kinase insert domain receptor (a type III receptor tyrosine kinase)
Band: 4q12
Quick LinksEntrez ID:3791; OMIM: 191306; Uniprot ID:VGFR2_HUMAN; ENSEMBL ID: ENSG00000128052; HGNC ID: 6307
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
46N-linked (GlcNAc...) (Potential).
66N-linked (GlcNAc...) (Potential).
96N-linked (GlcNAc...) (Potential).
143N-linked (GlcNAc...) (Potential).
158N-linked (GlcNAc...) (Potential).
245N-linked (GlcNAc...) (Potential).
318N-linked (GlcNAc...) (Potential).
374N-linked (GlcNAc...) (Potential).
395N-linked (GlcNAc...) (Potential).
511N-linked (GlcNAc...) (Potential).
523N-linked (GlcNAc...) (Potential).
580N-linked (GlcNAc...) (Potential).
613N-linked (GlcNAc...) (Potential).
619N-linked (GlcNAc...) (Potential).
631N-linked (GlcNAc...) (Potential).
675N-linked (GlcNAc...) (Potential).
704N-linked (GlcNAc...) (Potential).
721N-linked (GlcNAc...) (Potential).
801Phosphotyrosine.
951Phosphotyrosine.
996Phosphotyrosine.
1054Phosphotyrosine.
1059Phosphotyrosine; by autocatalysis.
1175Phosphotyrosine.
1214Phosphotyrosine.
Location(AA) Modifications Resource
46N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
66N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
96N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
143N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
158N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
245N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
318N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
374N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
395N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
511N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
523N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
580N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
613N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
619N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
631N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
675N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
704N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
721N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
801PhosphotyrosinePhospho.ELM 6.0
951Phosphotyrosine (KDR)Phospho.ELM 6.0
996Phosphotyrosine (KDR)Phospho.ELM 6.0
1054Phosphotyrosine (KDR)Phospho.ELM 6.0
1059Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1059Phosphotyrosine (KDR)Phospho.ELM 6.0
1175Phosphotyrosine (KDR)Phospho.ELM 6.0
1214Phosphotyrosine (KDR)Phospho.ELM 6.0
Location(AA) Modification Resource
21Phosphoserine(CAMK2)HMM predict
46N-linkedHMM predict
66N-linkedHMM predict
96N-linkedHMM predict
105Phosphotyrosine(Syk)HMM predict
143N-linkedHMM predict
158N-linkedHMM predict
209Phosphotyrosine(EGFR)HMM predict
214Phosphotyrosine(Jak)HMM predict
229Phosphoserine(CDK)HMM predict
245N-linkedHMM predict
281Phosphoserine(IKK)HMM predict
305Phosphotyrosine(INSR)HMM predict
315Phosphothreonine(PKC)HMM predict
318N-linkedHMM predict
374N-linkedHMM predict
395N-linkedHMM predict
440O-linkedHMM predict
442O-linkedHMM predict
446O-linkedHMM predict
471Phosphoserine(ATM)HMM predict
475Phosphoserine(IKK)HMM predict
511N-linkedHMM predict
562O-linkedHMM predict
580N-linkedHMM predict
613N-linkedHMM predict
619N-linkedHMM predict
622N-linkedHMM predict
640Phosphotyrosine(Jak)HMM predict
640Phosphotyrosine(INSR)HMM predict
675N-linkedHMM predict
689O-linkedHMM predict
689O-linkedHMM predict
704N-linkedHMM predict
721N-linkedHMM predict
723Phosphothreonine(PKC)HMM predict
735Phosphotyrosine(INSR)HMM predict
842MethylarginineHMM predict
940Phosphothreonine(PKC)HMM predict
951Phosphotyrosine(INSR)HMM predict
965Phosphoserine(IKK)HMM predict
968Phosphoserine(CK2)HMM predict
969Phosphoserine(ATM)HMM predict
972O-linkedHMM predict
982Phosphoserine(CK1)HMM predict
984Phosphoserine(CK2)HMM predict
984Phosphoserine(CK1)HMM predict
996PhosphotyrosineHMM predict
996Phosphotyrosine(Syk)HMM predict
1054Phosphotyrosine(Syk)HMM predict
1104Phosphoserine(CDC2)HMM predict
1130Phosphotyrosine(INSR)HMM predict
1148Phosphoserine(ATM)HMM predict
1175Phosphotyrosine(INSR)HMM predict
1193O-linkedHMM predict
1197Phosphoserine(CDC2)HMM predict
1197Phosphoserine(CDK)HMM predict
1197Phosphoserine(MAPK)HMM predict
1197Phosphoserine(IKK)HMM predict
1231Phosphoserine(PKA)HMM predict
1235Phosphoserine(PKG)HMM predict
1256N-linkedHMM predict
1279Phosphoserine(CDC2)HMM predict
1293Phosphoserine(PKG)HMM predict
1293Phosphoserine(CK2)HMM predict
1300N-linkedHMM predict
1309Phosphotyrosine(Syk)HMM predict
1311PhosphoserineHMM predict
1311Phosphoserine(ATM)HMM predict
1311Phosphoserine(CK2)HMM predict
1319Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002253
  • Location:chr4 55639406-55686518
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 55704809 55704987 178 18380
Nanog ESGSE20650 55693623 55694175 552 7381
Nanog hESGSE18292 55693604 55694202 598 7385
Oct4 hESGSE17917 55693733 55694065 332 7381
TFAP2C MCF7GSE21234 55704798 55705259 461 18510
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 55627595 55628180 585 11519
P300 T0-glioblastomaGSE21026 55627559 55628369 810 11443
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 55647670 55647905 235 0
CTCF G2GSE9613 55686072 55686884 812 0
FOXA1 MCF7GSE15244 55682999 55683682 683 0
FOXA1 eGFPGSE10845 55682999 55683682 683 0
FoxA1 MCF7MACSdata 55683274 55683633 359 0
Oct1 HelaGSE14283 55675979 55676015 36 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-126 hsa-mir-126 9 20816797
hsa-miR-126* hsa-mir-126 9 20816797
hsa-miR-221 hsa-mir-221 X 17379831
hsa-miR-221* hsa-mir-221 X 17379831
hsa-miR-27a hsa-mir-27a 19 21156786
hsa-miR-27a hsa-mir-27a 19 20488920
hsa-miR-27a* hsa-mir-27a 19 21156786
hsa-miR-27a* hsa-mir-27a 19 20488920
hsa-miR-296-3p hsa-mir-296 20 18977327
hsa-miR-296-5p hsa-mir-296 20 18977327
hsa-miR-429 hsa-mir-429 1 21233447
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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