Annotation Detail for KIF2A

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	KIF2A ( HK2,KIF2 )
Gene Full Name:	kinesin heavy chain member 2A
Band:	5q12.1
Quick Links	Entrez ID:3796; OMIM: 602591; Uniprot ID:KIF2A_HUMAN; ENSEMBL ID: ENSG00000068796; HGNC ID: 6318
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:4 results
Experimental PTM Sites from dbPTM:4 results
Predicted PTM Sites by profile HMM from dbPTM:25 results

Location(AA)	Modification
75	Phosphoserine.
78	Phosphothreonine.
140	Phosphoserine.
695	Phosphoserine.

Location(AA)	Modification	Resource
9	N-linked	HMM predict
11	Phosphoserine(CK1)	HMM predict
13	Phosphothreonine(PKC)	HMM predict
48	Phosphoserine(CDK)	HMM predict
48	O-linked	HMM predict
51	Phosphothreonine(CDC2)	HMM predict
51	Phosphothreonine(CDK)	HMM predict
57	O-linked	HMM predict
57	Phosphoserine(CDC2)	HMM predict
106	N-linked	HMM predict
108	Phosphoserine(CK2)	HMM predict
130	Phosphoserine(PKB)	HMM predict
130	Phosphoserine(PKG)	HMM predict
244	N-linked	HMM predict
251	Sulfotyrosine	HMM predict
312	Phosphotyrosine(INSR)	HMM predict
328	Phosphotyrosine(INSR)	HMM predict
328	Phosphotyrosine(EGFR)	HMM predict
336	Phosphotyrosine(EGFR)	HMM predict
400	O-linked	HMM predict
475	Phosphothreonine(CDK)	HMM predict
475	Phosphothreonine(CDC2)	HMM predict
559	Phosphoserine(CDC2)	HMM predict
627	Phosphotyrosine(Syk)	HMM predict
627	Sulfotyrosine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_004520
Location:chr5 61678712-61717966
strand:+

Upstream the gene:3 results
Downstream the gene:0 results
Inside the gene:1 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	61672052	61672230	178	6572
CTCF	CD4	SISSRdata	61672052	61672230	178	6572
CTCF	G2	GSE9613	61665997	61666595	598	12417

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ER	MCF7	GSE19013	61679277	61680065	788	0

Validated miRNA targets

miR Walk:18 results
Tarbase V5.0:1 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-183	hsa-mir-183	7	19940135
hsa-miR-183	hsa-mir-183	7	19940135
hsa-miR-183*	hsa-mir-183	7	19940135
hsa-miR-183*	hsa-mir-183	7	19940135
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
184	Unknown	MicroArray	miR-1	KIF2	n_a	15685193
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000068796		"cardiac and skeletal muscles, cardiogenesis"	n_a	n_a	"squamous cell, lymphocyte"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
21013	HTC	KIF2	chr5	61637834	61717966	203	HTC	PRO2214	chr5	61639836	61641366	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved