Annotation Detail for KRAS

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	KRAS ( C-K-RAS,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,KI-RAS,KRAS1,KRAS2,NS,NS3,RASK2 )
Gene Full Name:	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Band:	12p12.1
Quick Links	Entrez ID:3845; OMIM: 190070; Uniprot ID:RASK_HUMAN; ENSEMBL ID: ENSG00000133703; HGNC ID: 6407
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:4 results
Experimental PTM Sites from dbPTM:3 results
Predicted PTM Sites by profile HMM from dbPTM:9 results

Location(AA)	Modification
1	N-acetylmethionine; in GTPase KRas;
2	N-acetylthreonine; in GTPase KRas, N-
40	Effector region.
186	Cysteine methyl ester; in isoform 2A.

Location(AA)	Modifications	Resource
180	S-palmitoyl cysteine.	Swiss-Prot 53.0
186	Cysteine methyl ester; in isoform 2A.	Swiss-Prot 53.0
186	S-farnesyl cysteine; in isoform 2A.	Swiss-Prot 53.0

Location(AA)	Modification	Resource
32	Sulfotyrosine	HMM predict
40	Phosphotyrosine(Jak)	HMM predict
64	Phosphotyrosine(INSR)	HMM predict
64	Phosphotyrosine(SRC)	HMM predict
64	Phosphotyrosine(Syk)	HMM predict
85	N-linked	HMM predict
86	N-linked	HMM predict
180	S-palmitoyl	HMM predict
185	Lysine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_004985
Location:chr12 25249446-25295120
strand:-

Upstream the gene:9 results
Downstream the gene:0 results
Inside the gene:5 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ER	MCF7	GSE19013	25308672	25309293	621	13862
ETS1	Jurkat	GSE17954	25294875	25295547	672	91
FOXA1	DLD1	GSE12801	25299600	25300617	1017	4988
FOXA1	MCF7	GSE15244	25295467	25296046	579	636
KLF4	hES	GSE17917	25295128	25295520	392	204
PHF8	293T	GSE20725	25294820	25295902	1082	241
Rb	Growing	GSE19898	25295086	25295326	240	86
TFAP2C	MCF7	GSE21234	25295149	25295385	236	147
USF1	HepG2	E	25300966	25301496	530	6111

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	25294316	25294634	318
H3ac	HepG2	E	25293824	25294504	680
Oct1	Hela	GSE14283	25273246	25273308	62
TAF	Hela	GSE8489	25289276	25290222	946
hScc1	CdLS	GSE12603	25285035	25285788	753

Validated miRNA targets

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miR Walk:292 results
Tarbase V5.0:1 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	21285251
hsa-let-7a	hsa-let-7a-2	11	21285251
hsa-let-7a	hsa-let-7a-3	22	21285251
hsa-let-7a	hsa-let-7a-1	9	20978195
hsa-let-7a	hsa-let-7a-2	11	20978195
hsa-let-7a	hsa-let-7a-3	22	20978195
hsa-let-7a	hsa-let-7a-1	9	20093556
hsa-let-7a	hsa-let-7a-2	11	20093556
hsa-let-7a	hsa-let-7a-3	22	20093556
hsa-let-7a	hsa-let-7a-1	9	20676756
hsa-let-7a	hsa-let-7a-2	11	20676756
hsa-let-7a	hsa-let-7a-3	22	20676756
hsa-let-7a	hsa-let-7a-1	9	20647319
hsa-let-7a	hsa-let-7a-2	11	20647319
hsa-let-7a	hsa-let-7a-3	22	20647319
hsa-let-7a	hsa-let-7a-1	9	20603437
hsa-let-7a	hsa-let-7a-2	11	20603437
hsa-let-7a	hsa-let-7a-3	22	20603437
hsa-let-7a	hsa-let-7a-1	9	20177422
hsa-let-7a	hsa-let-7a-2	11	20177422
hsa-let-7a	hsa-let-7a-3	22	20177422
hsa-let-7a	hsa-let-7a-1	9	19380522
hsa-let-7a	hsa-let-7a-2	11	19380522
hsa-let-7a	hsa-let-7a-3	22	19380522
hsa-let-7a	hsa-let-7a-1	9	18922928
hsa-let-7a	hsa-let-7a-2	11	18922928
hsa-let-7a	hsa-let-7a-3	22	18922928
hsa-let-7a	hsa-let-7a-1	9	17728006
hsa-let-7a	hsa-let-7a-2	11	17728006
hsa-let-7a	hsa-let-7a-3	22	17728006
hsa-let-7a	hsa-let-7a-1	9	15766527
hsa-let-7a	hsa-let-7a-2	11	15766527
hsa-let-7a	hsa-let-7a-3	22	15766527
hsa-let-7a	hsa-let-7a-1	9	20216554
hsa-let-7a	hsa-let-7a-2	11	20216554
hsa-let-7a	hsa-let-7a-3	22	20216554
hsa-let-7a*	hsa-let-7a-1	9	20676756
hsa-let-7a*	hsa-let-7a-3	22	20676756
hsa-let-7a*	hsa-let-7a-1	9	20647319
hsa-let-7a*	hsa-let-7a-3	22	20647319
hsa-let-7a*	hsa-let-7a-1	9	20603437
hsa-let-7a*	hsa-let-7a-3	22	20603437
hsa-let-7a*	hsa-let-7a-1	9	20177422
hsa-let-7a*	hsa-let-7a-3	22	20177422
hsa-let-7a*	hsa-let-7a-1	9	19380522
hsa-let-7a*	hsa-let-7a-3	22	19380522
hsa-let-7a*	hsa-let-7a-1	9	18922928
hsa-let-7a*	hsa-let-7a-3	22	18922928
hsa-let-7a*	hsa-let-7a-1	9	17728006
hsa-let-7a*	hsa-let-7a-3	22	17728006
hsa-let-7a*	hsa-let-7a-1	9	15766527
hsa-let-7a*	hsa-let-7a-3	22	15766527
hsa-let-7a*	hsa-let-7a-1	9	20216554
hsa-let-7a*	hsa-let-7a-3	22	20216554
hsa-let-7b	hsa-let-7b	22	20676756
hsa-let-7b	hsa-let-7b	22	20647319
hsa-let-7b	hsa-let-7b	22	20603437
hsa-let-7b	hsa-let-7b	22	20177422
hsa-let-7b	hsa-let-7b	22	19380522
hsa-let-7b	hsa-let-7b	22	18922928
hsa-let-7b	hsa-let-7b	22	17728006
hsa-let-7b	hsa-let-7b	22	15766527
hsa-let-7b	hsa-let-7b	22	20216554
hsa-let-7b*	hsa-let-7b	22	20676756
hsa-let-7b*	hsa-let-7b	22	20647319
hsa-let-7b*	hsa-let-7b	22	20603437
hsa-let-7b*	hsa-let-7b	22	20177422
hsa-let-7b*	hsa-let-7b	22	19380522
hsa-let-7b*	hsa-let-7b	22	18922928
hsa-let-7b*	hsa-let-7b	22	17728006
hsa-let-7b*	hsa-let-7b	22	15766527
hsa-let-7b*	hsa-let-7b	22	20216554
hsa-let-7c	hsa-let-7c	21	20676756
hsa-let-7c	hsa-let-7c	21	20647319
hsa-let-7c	hsa-let-7c	21	20603437
hsa-let-7c	hsa-let-7c	21	20177422
hsa-let-7c	hsa-let-7c	21	19380522
hsa-let-7c	hsa-let-7c	21	18922928
hsa-let-7c	hsa-let-7c	21	17728006
hsa-let-7c	hsa-let-7c	21	15766527
hsa-let-7c	hsa-let-7c	21	20216554
hsa-let-7c*	hsa-let-7c	21	20676756
hsa-let-7c*	hsa-let-7c	21	20647319
hsa-let-7c*	hsa-let-7c	21	20603437
hsa-let-7c*	hsa-let-7c	21	20177422
hsa-let-7c*	hsa-let-7c	21	19380522
hsa-let-7c*	hsa-let-7c	21	18922928
hsa-let-7c*	hsa-let-7c	21	17728006
hsa-let-7c*	hsa-let-7c	21	15766527
hsa-let-7c*	hsa-let-7c	21	20216554
hsa-let-7d	hsa-let-7d	9	21266788
hsa-let-7d	hsa-let-7d	9	20676756
hsa-let-7d	hsa-let-7d	9	20647319
hsa-let-7d	hsa-let-7d	9	20603437
hsa-let-7d	hsa-let-7d	9	20177422
hsa-let-7d	hsa-let-7d	9	19380522
hsa-let-7d	hsa-let-7d	9	18922928
hsa-let-7d	hsa-let-7d	9	17728006
hsa-let-7d	hsa-let-7d	9	15766527
hsa-let-7d	hsa-let-7d	9	20216554
hsa-let-7d*	hsa-let-7d	9	21266788
hsa-let-7d*	hsa-let-7d	9	20676756
hsa-let-7d*	hsa-let-7d	9	20647319
hsa-let-7d*	hsa-let-7d	9	20603437
hsa-let-7d*	hsa-let-7d	9	20177422
hsa-let-7d*	hsa-let-7d	9	19380522
hsa-let-7d*	hsa-let-7d	9	18922928
hsa-let-7d*	hsa-let-7d	9	17728006
hsa-let-7d*	hsa-let-7d	9	15766527
hsa-let-7d*	hsa-let-7d	9	20216554
hsa-let-7e	hsa-let-7e	19	20676756
hsa-let-7e	hsa-let-7e	19	20647319
hsa-let-7e	hsa-let-7e	19	20603437
hsa-let-7e	hsa-let-7e	19	20177422
hsa-let-7e	hsa-let-7e	19	19380522
hsa-let-7e	hsa-let-7e	19	18922928
hsa-let-7e	hsa-let-7e	19	17728006
hsa-let-7e	hsa-let-7e	19	15766527
hsa-let-7e	hsa-let-7e	19	20216554
hsa-let-7e*	hsa-let-7e	19	20676756
hsa-let-7e*	hsa-let-7e	19	20647319
hsa-let-7e*	hsa-let-7e	19	20603437
hsa-let-7e*	hsa-let-7e	19	20177422
hsa-let-7e*	hsa-let-7e	19	19380522
hsa-let-7e*	hsa-let-7e	19	18922928
hsa-let-7e*	hsa-let-7e	19	17728006
hsa-let-7e*	hsa-let-7e	19	15766527
hsa-let-7e*	hsa-let-7e	19	20216554
hsa-let-7f	hsa-let-7f-1	9	20676756
hsa-let-7f	hsa-let-7f-2	X	20676756
hsa-let-7f	hsa-let-7f-1	9	20647319
hsa-let-7f	hsa-let-7f-2	X	20647319
hsa-let-7f	hsa-let-7f-1	9	20603437
hsa-let-7f	hsa-let-7f-2	X	20603437
hsa-let-7f	hsa-let-7f-1	9	20177422
hsa-let-7f	hsa-let-7f-2	X	20177422
hsa-let-7f	hsa-let-7f-1	9	19380522
hsa-let-7f	hsa-let-7f-2	X	19380522
hsa-let-7f	hsa-let-7f-1	9	18922928
hsa-let-7f	hsa-let-7f-2	X	18922928
hsa-let-7f	hsa-let-7f-1	9	17728006
hsa-let-7f	hsa-let-7f-2	X	17728006
hsa-let-7f	hsa-let-7f-1	9	15766527
hsa-let-7f	hsa-let-7f-2	X	15766527
hsa-let-7f	hsa-let-7f-1	9	20216554
hsa-let-7f	hsa-let-7f-2	X	20216554
hsa-let-7f-1*	hsa-let-7f-1	9	20676756
hsa-let-7f-1*	hsa-let-7f-1	9	20647319
hsa-let-7f-1*	hsa-let-7f-1	9	20603437
hsa-let-7f-1*	hsa-let-7f-1	9	20177422
hsa-let-7f-1*	hsa-let-7f-1	9	19380522
hsa-let-7f-1*	hsa-let-7f-1	9	18922928
hsa-let-7f-1*	hsa-let-7f-1	9	17728006
hsa-let-7f-1*	hsa-let-7f-1	9	15766527
hsa-let-7f-1*	hsa-let-7f-1	9	20216554
hsa-let-7f-2*	hsa-let-7f-2	X	20676756
hsa-let-7f-2*	hsa-let-7f-2	X	20647319
hsa-let-7f-2*	hsa-let-7f-2	X	20603437
hsa-let-7f-2*	hsa-let-7f-2	X	20177422
hsa-let-7f-2*	hsa-let-7f-2	X	19380522
hsa-let-7f-2*	hsa-let-7f-2	X	18922928
hsa-let-7f-2*	hsa-let-7f-2	X	17728006
hsa-let-7f-2*	hsa-let-7f-2	X	15766527
hsa-let-7f-2*	hsa-let-7f-2	X	20216554
hsa-let-7g	hsa-let-7g	3	20818338
hsa-let-7g	hsa-let-7g	3	19745602
hsa-let-7g	hsa-let-7g	3	20676756
hsa-let-7g	hsa-let-7g	3	20647319
hsa-let-7g	hsa-let-7g	3	20603437
hsa-let-7g	hsa-let-7g	3	20177422
hsa-let-7g	hsa-let-7g	3	19380522
hsa-let-7g	hsa-let-7g	3	18922928
hsa-let-7g	hsa-let-7g	3	17728006
hsa-let-7g	hsa-let-7g	3	15766527
hsa-let-7g	hsa-let-7g	3	20216554
hsa-let-7g*	hsa-let-7g	3	20818338
hsa-let-7g*	hsa-let-7g	3	19745602
hsa-let-7g*	hsa-let-7g	3	20676756
hsa-let-7g*	hsa-let-7g	3	20647319
hsa-let-7g*	hsa-let-7g	3	20603437
hsa-let-7g*	hsa-let-7g	3	20177422
hsa-let-7g*	hsa-let-7g	3	19380522
hsa-let-7g*	hsa-let-7g	3	18922928
hsa-let-7g*	hsa-let-7g	3	17728006
hsa-let-7g*	hsa-let-7g	3	15766527
hsa-let-7g*	hsa-let-7g	3	20216554
hsa-let-7i	hsa-let-7i	12	20676756
hsa-let-7i	hsa-let-7i	12	20647319
hsa-let-7i	hsa-let-7i	12	20603437
hsa-let-7i	hsa-let-7i	12	20177422
hsa-let-7i	hsa-let-7i	12	19380522
hsa-let-7i	hsa-let-7i	12	18922928
hsa-let-7i	hsa-let-7i	12	17728006
hsa-let-7i	hsa-let-7i	12	15766527
hsa-let-7i	hsa-let-7i	12	20216554
hsa-let-7i*	hsa-let-7i	12	20676756
hsa-let-7i*	hsa-let-7i	12	20647319
hsa-let-7i*	hsa-let-7i	12	20603437
hsa-let-7i*	hsa-let-7i	12	20177422
hsa-let-7i*	hsa-let-7i	12	19380522
hsa-let-7i*	hsa-let-7i	12	18922928
hsa-let-7i*	hsa-let-7i	12	17728006
hsa-let-7i*	hsa-let-7i	12	15766527
hsa-let-7i*	hsa-let-7i	12	20216554
hsa-miR-125b	hsa-mir-125b-1	11	20216554
hsa-miR-125b	hsa-mir-125b-2	21	20216554
hsa-miR-126	hsa-mir-126	9	20216554
hsa-miR-126*	hsa-mir-126	9	20216554
hsa-miR-137	hsa-mir-137	1	20818338
hsa-miR-143	hsa-mir-143	5	19137007
hsa-miR-143	hsa-mir-143	5	21159816
hsa-miR-143*	hsa-mir-143	5	19137007
hsa-miR-143*	hsa-mir-143	5	21159816
hsa-miR-144	hsa-mir-144	17	21285251
hsa-miR-144*	hsa-mir-144	17	21285251
hsa-miR-145	hsa-mir-145	5	21159816
hsa-miR-145*	hsa-mir-145	5	21159816
hsa-miR-155	hsa-mir-155	21	20978195
hsa-miR-155	hsa-mir-155	21	20818338
hsa-miR-155*	hsa-mir-155	21	20978195
hsa-miR-155*	hsa-mir-155	21	20818338
hsa-miR-15a	hsa-mir-15a	13	20216554
hsa-miR-15a*	hsa-mir-15a	13	20216554
hsa-miR-15b	hsa-mir-15b	3	20216554
hsa-miR-15b*	hsa-mir-15b	3	20216554
hsa-miR-16	hsa-mir-16-1	13	20216554
hsa-miR-16	hsa-mir-16-2	3	20216554
hsa-miR-17	hsa-mir-17	13	16878133
hsa-miR-17*	hsa-mir-17	13	16878133
hsa-miR-181c	hsa-mir-181c	19	20080834
hsa-miR-181c*	hsa-mir-181c	19	20080834
hsa-miR-183	hsa-mir-183	7	19047896
hsa-miR-183*	hsa-mir-183	7	19047896
hsa-miR-18a	hsa-mir-18a	13	19372139
hsa-miR-18a*	hsa-mir-18a	13	19372139
hsa-miR-18b	hsa-mir-18b	0	20818338
hsa-miR-18b*	hsa-mir-18b	0	20818338
hsa-miR-192	hsa-mir-192	11	19047896
hsa-miR-192*	hsa-mir-192	11	19047896
hsa-miR-200a	hsa-mir-200a	1	21285251
hsa-miR-200a*	hsa-mir-200a	1	21285251
hsa-miR-203	hsa-mir-203	14	20216554
hsa-miR-205	hsa-mir-205	1	20093556
hsa-miR-20a	hsa-mir-20a	13	20818338
hsa-miR-20a*	hsa-mir-20a	13	20818338
hsa-miR-21	hsa-mir-21	17	20978195
hsa-miR-21	hsa-mir-21	17	20093556
hsa-miR-21	hsa-mir-21	17	18335499
hsa-miR-21	hsa-mir-21	17	20216554
hsa-miR-21*	hsa-mir-21	17	20978195
hsa-miR-21*	hsa-mir-21	17	20093556
hsa-miR-21*	hsa-mir-21	17	18335499
hsa-miR-21*	hsa-mir-21	17	20216554
hsa-miR-216a	hsa-mir-216a	2	20216554
hsa-miR-217	hsa-mir-217	2	20675343
hsa-miR-217	hsa-mir-217	2	20216554
hsa-miR-221	hsa-mir-221	X	20093556
hsa-miR-221*	hsa-mir-221	X	20093556
hsa-miR-222	hsa-mir-222	X	20093556
hsa-miR-222*	hsa-mir-222	X	20093556
hsa-miR-23b	hsa-mir-23b	9	20216554
hsa-miR-23b*	hsa-mir-23b	9	20216554
hsa-miR-25	hsa-mir-25	7	20818338
hsa-miR-25*	hsa-mir-25	7	20818338
hsa-miR-29b	hsa-mir-29b-1	7	20978195
hsa-miR-29b	hsa-mir-29b-2	1	20978195
hsa-miR-32	hsa-mir-32	9	20818338
hsa-miR-32*	hsa-mir-32	9	20818338
hsa-miR-324-5p	hsa-mir-324	17	20216554
hsa-miR-326	hsa-mir-326	11	20216554
hsa-miR-328	hsa-mir-328	16	20818338
hsa-miR-342-3p	hsa-mir-342	14	20818338
hsa-miR-342-5p	hsa-mir-342	14	20818338
hsa-miR-34a	hsa-mir-34a	1	20978195
hsa-miR-34a*	hsa-mir-34a	1	20978195
hsa-miR-34b	hsa-mir-34b	11	20978195
hsa-miR-34b*	hsa-mir-34b	11	20978195
hsa-miR-34c-3p	hsa-mir-34c	11	20978195
hsa-miR-34c-3p	hsa-mir-34c	11	20818338
hsa-miR-34c-5p	hsa-mir-34c	11	20978195
hsa-miR-34c-5p	hsa-mir-34c	11	20818338
hsa-miR-372	hsa-mir-372	19	20216554
hsa-miR-373	hsa-mir-373	19	20216554
hsa-miR-373*	hsa-mir-373	19	20216554
hsa-miR-495	hsa-mir-495	14	20818338
hsa-miR-9	hsa-mir-9-1	1	19137007
hsa-miR-9	hsa-mir-9-2	5	19137007
hsa-miR-9	hsa-mir-9-3	15	19137007
hsa-miR-92a	hsa-mir-92a-1	13	16878133
hsa-miR-92a	hsa-mir-92a-2	X	16878133
hsa-miR-96	hsa-mir-96	7	20610624
hsa-miR-96*	hsa-mir-96	7	20610624

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
100	mRNA repression	TRUE	let-7	KRAS	in vitro reporter gene assay (Luciferase)	15766527
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000133703		adult and embryonic CNS	n_a	n_a	"epithelium, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for KRAS

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics