Annotation Detail for RHOB

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Basic Information Top

Gene Symbol:	RHOB ( ARH6,ARHB,MST081,MSTP081,RHOH6 )
Gene Full Name:	ras homolog gene family, member B
Band:	2p24.1
Quick Links	Entrez ID:388; OMIM: 165370; Uniprot ID:RHOB_HUMAN; ENSEMBL ID: ENSG00000143878; HGNC ID: 668
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
41	ADP-ribosylasparagine; by botulinum toxin
42	Effector region (Potential).
154	Phosphotyrosine (By similarity).
193	Cysteine methyl ester.

Location(AA)	Modifications	Resource
41	ADP-ribosylasparagine (by botulinumtoxin) (By similarity).	Swiss-Prot 53.0
189	S-palmitoyl cysteine.	Swiss-Prot 53.0
192	S-palmitoyl cysteine.	Swiss-Prot 53.0
193	Cysteine methyl ester.	Swiss-Prot 53.0
193	S-farnesyl cysteine; in plasma membraneform.	Swiss-Prot 53.0
193	S-geranylgeranyl cysteine; in endosomalform.	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	20497258	20497682	424	12846
Fos	K562	GSE19551	20493900	20494596	696	16068
Fos	K562	GSE19551	20509939	20510419	480	137
H3ac	HepG2	E	20508444	20508810	366	1689
KLF4	hES	GSE17917	20504273	20504441	168	5959
Oct1	H2O2-Hela	GSE14283	20492444	20492471	27	17858
Pol2	GM12878	GSE19551	20509880	20510655	775	48
VDR	GM10861-stim	GSE22484	20492262	20493637	1375	17366
hScc1	Bcell	GSE12603	20506428	20506849	421	3677

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	20515948	20516220	272	3404
CTCF	G2	GSE9613	20530459	20530666	207	17882
FOXA1	MCF7	GSE15244	20521154	20521355	201	8574
FOXA1	MCF7	GSE15244	20531948	20533219	1271	19903
FoxA1	MCF7	MACSdata	20520950	20521147	197	8368
FoxA1	MCF7	MACSdata	20521191	20521304	113	8567
RARA	MCF7	GSE15244	20528902	20530132	1230	16837

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	20509885	20511580	1695
H3ac	HepG2	E	20511632	20512422	790
PHF8	293T	GSE20725	20509857	20511150	1293
PHF8	Hs68minusFBS	GSE20725	20509805	20511016	1211
PHF8	Hs68plusFBS	GSE20725	20509802	20512276	2474
hScc1	Bcell	GSE12603	20510150	20510622	472
hScc1	Bcell	GSE12603	20510890	20511474	584
hScc1	G2	GSE9613	20509657	20512031	2374

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-21	hsa-mir-21	17	21347332
hsa-miR-21	hsa-mir-21	17	20460403
hsa-miR-21*	hsa-mir-21	17	21347332
hsa-miR-21*	hsa-mir-21	17	20460403
hsa-miR-223	hsa-mir-223	X	19850724
hsa-miR-223*	hsa-mir-223	X	19850724
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
889	Unknown	pSILAC	let-7b	RHOB	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000143878		n_a	n_a	n_a	"epithelium, lymphoblast, lymphocyte"	"benign tumour, malignant tumour, carcinoma, leukaemia"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018