AutismKB 2.0

Annotation Detail for SBK1


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Basic Information Top
Gene Symbol:SBK1 ( Sbk )
Gene Full Name: SH3-binding domain kinase 1
Band: 16p11.2
Quick LinksEntrez ID:388228; OMIM: NA; Uniprot ID:SBK1_HUMAN; ENSEMBL ID: ENSG00000188322; HGNC ID: 17699
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
63Phosphothreonine.
64Phosphotyrosine.
Location(AA) Modifications Resource
63Phosphothreonine.Swiss-Prot 53.0
63PhosphothreoninePhospho.ELM 6.0
64Phosphotyrosine.Swiss-Prot 53.0
64PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
13O-linkedHMM predict
17S-palmitoylHMM predict
64Phosphotyrosine(INSR)HMM predict
85N-linkedHMM predict
107Phosphoserine(CDC2)HMM predict
107Phosphoserine(ATM)HMM predict
285Phosphothreonine(PKA)HMM predict
363O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001024401
  • Location:chr16 28211340-28242662
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 28196479 28196938 459 14632
CTCF CD4SISSRdata 28196479 28196938 459 14632
CTCF G2GSE9613 28196492 28196968 476 14611
CTCF G2GSE9613 28200162 28200606 444 10957
Rb SenescentGSE19898 28196585 28196909 324 14594
Rb shRbQuiescentGSE19898 28196482 28196762 280 14719
TAF HelaGSE8489 28208937 28209150 213 2297
hScc1 BcellGSE12603 28196492 28196968 476 14611
hScc1 CdLSGSE12603 28196492 28196968 476 14611
hScc1 G2GSE9613 28196492 28196968 476 14611
p130 shRbQuiescentGSE19898 28196414 28197175 761 14546
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 28245739 28246121 382 3268
CTCF CD4SISSRdata 28245739 28246121 382 3268
CTCF HelaGSE12889 28245782 28245962 180 3210
CTCF JurkatGSE12889 28245724 28246140 416 3270
CTCF G2GSE9613 28245771 28246198 427 3322
FOXA1 MCF7GSE15244 28243059 28243718 659 726
Fos K562GSE19551 28249106 28249478 372 6630
FoxA1 MCF7MACSdata 28243425 28243736 311 918
RNAII Tamoxifen-MCF7GSE14664 28244199 28244235 36 1555
TFAP2C MCF7GSE21234 28243106 28243938 832 860
hScc1 BcellGSE12603 28245771 28246198 427 3322
hScc1 CdLSGSE12603 28245629 28246198 569 3251
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 28227219 28229998 2779 0
CTCF CD4GSE12889 28235897 28236303 406 0
CTCF CD4SISSRdata 28235897 28236303 406 0
CTCF HelaGSE12889 28240649 28240856 207 0
CTCF JurkatGSE12889 28235855 28236258 403 0
CTCF G2GSE9613 28228746 28229176 430 0
CTCF G2GSE9613 28231389 28231514 125 0
CTCF G2GSE9613 28235853 28236251 398 0
CTCF G2GSE9613 28238302 28238969 667 0
CTCF G2GSE9613 28239585 28239923 338 0
CTCF G2GSE9613 28240491 28241058 567 0
CTCF G2GSE9613 28242275 28242441 166 0
Myc K562GSE19551 28222977 28223232 255 0
Myc K562GSE19551 28234803 28235353 550 0
NRSF JurkatGSE13047 28222600 28223401 801 0
NRSF JurkatSISSRdata 28222894 28223340 446 0
NRSF mAbJurkat 28218454 28219009 555 0
NRSF mAbJurkat 28220843 28222279 1436 0
NRSF mAbJurkat 28224664 28224841 177 0
NRSF mAbJurkat 28225275 28225649 374 0
NRSF-mono JurkatQuESTdata 28222625 28223406 781 0
NRSF pAbJurkat 28221919 28222279 360 0
NRSF-poly JurkatQuESTdata 28216835 28217404 569 0
NRSF-poly JurkatQuESTdata 28222600 28223383 783 0
Oct1 H2O2-HelaGSE14283 28222409 28222437 28 0
Oct1 HelaGSE14283 28236409 28236438 29 0
TFAP2C MCF7GSE21234 28235878 28236267 389 0
hScc1 BcellGSE12603 28211475 28212116 641 0
hScc1 BcellGSE12603 28235853 28236427 574 0
hScc1 BcellGSE12603 28239405 28240105 700 0
hScc1 BcellGSE12603 28240629 28241058 429 0
hScc1 CdLSGSE12603 28235853 28236464 611 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018