AutismKB 2.0

Annotation Detail for AFF3


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Basic Information Top
Gene Symbol:AFF3 ( LAF4,MLLT2-like )
Gene Full Name: AF4/FMR2 family, member 3
Band: 2q11.2
Quick LinksEntrez ID:3899; OMIM: 601464; Uniprot ID:AFF3_HUMAN; ENSEMBL ID: ENSG00000144218; HGNC ID: 6473
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
310Phosphothreonine.
316Phosphoserine.
393Phosphoserine.
755Phosphoserine.
881Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
47N-linkedHMM predict
76Phosphotyrosine(INSR)HMM predict
76SulfotyrosineHMM predict
103Phosphothreonine(CDC2)HMM predict
103Phosphothreonine(MAPK)HMM predict
123O-linkedHMM predict
124O-linkedHMM predict
124O-linkedHMM predict
124Phosphoserine(IKK)HMM predict
128O-linkedHMM predict
129O-linkedHMM predict
131O-linkedHMM predict
131O-linkedHMM predict
132Phosphothreonine(MAPK)HMM predict
163Phosphothreonine(PKA)HMM predict
195Phosphothreonine(PKC)HMM predict
255Phosphoserine(CK1)HMM predict
257O-linkedHMM predict
270Phosphoserine(IKK)HMM predict
295Phosphoserine(CK1)HMM predict
355Phosphoserine(ATM)HMM predict
358O-linkedHMM predict
358Phosphoserine(IKK)HMM predict
373Phosphoserine(CK2)HMM predict
374Phosphoserine(CK2)HMM predict
409O-linkedHMM predict
410Phosphoserine(IKK)HMM predict
417Phosphoserine(CK1)HMM predict
428O-linkedHMM predict
428Phosphoserine(IKK)HMM predict
430Phosphoserine(CK1)HMM predict
430Phosphoserine(IKK)HMM predict
431Phosphoserine(CK1)HMM predict
432Phosphoserine(ATM)HMM predict
432Phosphoserine(IKK)HMM predict
434Phosphoserine(CK1)HMM predict
434Phosphoserine(ATM)HMM predict
436Phosphoserine(CK2)HMM predict
436Phosphoserine(IKK)HMM predict
443Phosphoserine(CK1)HMM predict
448Phosphoserine(CK1)HMM predict
463Phosphoserine(CK1)HMM predict
491Phosphoserine(CK1)HMM predict
496Phosphotyrosine(INSR)HMM predict
496Phosphotyrosine(Jak)HMM predict
496Phosphotyrosine(Syk)HMM predict
497Phosphotyrosine(Syk)HMM predict
559O-linkedHMM predict
559O-linkedHMM predict
582Phosphoserine(PKG)HMM predict
588Phosphothreonine(PKA)HMM predict
588Phosphothreonine(PKC)HMM predict
591Phosphothreonine(PKA)HMM predict
594Phosphothreonine(PKA)HMM predict
652Phosphothreonine(PKA)HMM predict
679Phosphoserine(CK1)HMM predict
679Phosphoserine(CK2)HMM predict
683Phosphoserine(CK2)HMM predict
695O-linkedHMM predict
695Phosphothreonine(PKC)HMM predict
699Phosphoserine(PKG)HMM predict
702Phosphoserine(CK1)HMM predict
702Phosphoserine(CK2)HMM predict
743Phosphotyrosine(SRC)HMM predict
755Phosphoserine(CDC2)HMM predict
755Phosphoserine(MAPK)HMM predict
797O-linkedHMM predict
799O-linkedHMM predict
799O-linkedHMM predict
803O-linkedHMM predict
805O-linkedHMM predict
806O-linkedHMM predict
808Phosphothreonine(MAPK)HMM predict
808PhosphothreonineHMM predict
829Phosphotyrosine(EGFR)HMM predict
829Phosphotyrosine(INSR)HMM predict
829Phosphotyrosine(Syk)HMM predict
847O-linkedHMM predict
850O-linkedHMM predict
850Phosphoserine(IKK)HMM predict
881Phosphoserine(CDC2)HMM predict
881Phosphoserine(MAPK)HMM predict
891Phosphotyrosine(INSR)HMM predict
898Phosphoserine(CK1)HMM predict
899Phosphoserine(CDC2)HMM predict
910O-linkedHMM predict
910Phosphoserine(IKK)HMM predict
912Phosphoserine(CDC2)HMM predict
921Phosphoserine(IKK)HMM predict
950Phosphothreonine(PKC)HMM predict
954Phosphoserine(IKK)HMM predict
1029Phosphotyrosine(Syk)HMM predict
1052N-linkedHMM predict
1054Phosphothreonine(CDC2)HMM predict
1054Phosphothreonine(MAPK)HMM predict
1096N-linkedHMM predict
1110O-linkedHMM predict
1116O-linkedHMM predict
1116Phosphothreonine(CDC2)HMM predict
1118O-linkedHMM predict
1118Phosphoserine(CDC2)HMM predict
1118Phosphoserine(CDK)HMM predict
1121O-linkedHMM predict
1121Phosphoserine(IKK)HMM predict
1123N-linkedHMM predict
1125O-linkedHMM predict
1125Phosphoserine(CDC2)HMM predict
1128Phosphoserine(IKK)HMM predict
1129Phosphoserine(CK1)HMM predict
1138N-linkedHMM predict
1140O-linkedHMM predict
1143Phosphoserine(CDC2)HMM predict
1220ArginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001025108
  • Location:chr2 99530149-100088476
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 99518380 99518594 214 11663
CTCF G2GSE9613 99519495 99519883 388 10461
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 99680852 99682383 1531 0
CTCF CD4GSE12889 99542012 99542335 323 0
CTCF CD4SISSRdata 99542012 99542335 323 0
CTCF HelaGSE12889 99541819 99542276 457 0
CTCF G2GSE9613 100078651 100079065 414 0
CTCF G2GSE9613 100086970 100087141 171 0
CTCF G2GSE9613 100087895 100088271 376 0
CTCF G2GSE9613 99541559 99542509 950 0
CTCF G2GSE9613 99598357 99598766 409 0
CTCF G2GSE9613 99605701 99605885 184 0
CTCF G2GSE9613 99619557 99619824 267 0
CTCF G2GSE9613 99648865 99649192 327 0
CTCF G2GSE9613 99809646 99810051 405 0
CTCF G2GSE9613 99853087 99853475 388 0
CTCF G2GSE9613 99874356 99874538 182 0
CTCF G2GSE9613 99884745 99884894 149 0
CTCF G2GSE9613 99887796 99888173 377 0
CTCF G2GSE9613 99923764 99924130 366 0
CTCF G2GSE9613 99925210 99925370 160 0
CTCF G2GSE9613 99991666 99991812 146 0
ER Breast-CancerGSE22609 99556657 99557655 998 0
ER Breast-CancerGSE22609 99619465 99619948 483 0
ER Breast-CancerGSE22609 99860715 99861453 738 0
ER E2-MCF7GSE14664 99549786 99549836 50 0
ER E2-MCF7GSE14664 99978432 99978469 37 0
ER Fulvestrant-MCF7GSE14664 99919150 99919185 35 0
ER MCF7GSE19013 99556620 99557469 849 0
ER MCF7GSE19013 99592411 99593436 1025 0
ER MCF7GSE19013 99600649 99601582 933 0
ER MCF7GSE19013 99619348 99620459 1111 0
ER MCF7GSE19013 99996375 99997239 864 0
FOXA1 MCF7GSE15244 100049616 100051348 1732 0
FOXA1 MCF7GSE15244 99784210 99784605 395 0
FOXA1 MCF7GSE15244 99789116 99790180 1064 0
FOXA1 MCF7GSE15244 99793042 99793491 449 0
Fos K562GSE19551 99996641 99997219 578 0
FoxA1 MCF7MACSdata 100050532 100051054 522 0
FoxA1 MCF7MACSdata 100058630 100058825 195 0
FoxA1 MCF7MACSdata 99784237 99784468 231 0
FoxA1 MCF7MACSdata 99789108 99789359 251 0
GABP k562GSE8489 99754330 99754830 500 0
GABP k562GSE8489 99762810 99762953 143 0
H3K27me3 colorectalcancer 100086003 100086731 728 0
H3K27me3 colorectalcancer 100088169 100088721 552 0
Myc K562GSE19551 100029985 100030216 231 0
Myc K562GSE19551 99573402 99573690 288 0
Myc K562GSE19551 99598358 99598651 293 0
Myc K562GSE19551 99996812 99997159 347 0
NRSF JurkatSISSRdata 99681150 99681319 169 0
Oct1 H2O2-HelaGSE14283 99616780 99616811 31 0
Oct1 H2O2-HelaGSE14283 99642365 99642396 31 0
Oct1 H2O2-HelaGSE14283 99801649 99801676 27 0
Oct1 H2O2-HelaGSE14283 99834355 99834383 28 0
Oct1 HelaGSE14283 100078689 100078719 30 0
Oct1 HelaGSE14283 99571952 99571990 38 0
Oct1 HelaGSE14283 99616778 99616810 32 0
Oct1 HelaGSE14283 99834355 99834383 28 0
Oct1 HelaGSE14283 99919156 99919187 31 0
Oct1 HelaGSE14283 99959675 99959708 33 0
P300 T0-glioblastomaGSE21026 99645112 99646335 1223 0
P300 T0-glioblastomaGSE21026 99680826 99682519 1693 0
P300 T30-glioblastomaGSE21026 99645267 99646384 1117 0
P300 T30-glioblastomaGSE21026 99680674 99682495 1821 0
P300 T30-glioblastomaGSE21026 99736985 99737893 908 0
P300 T30-glioblastomaGSE21026 99862809 99863955 1146 0
RARA MCF7GSE15244 99618926 99620321 1395 0
RARA MCF7GSE15244 99789042 99790180 1138 0
RARA MCF7GSE15244 99792716 99793491 775 0
Rb GrowingGSE19898 99711957 99712142 185 0
Rb SenescentGSE19898 99631328 99631596 268 0
Stat6 IL-4-hr4GSE17850 99660427 99660894 467 0
TFAP2C MCF7GSE21234 100049719 100050241 522 0
TFAP2C MCF7GSE21234 99592613 99593177 564 0
TFAP2C MCF7GSE21234 99619400 99620076 676 0
TFAP2C MCF7GSE21234 99683275 99683810 535 0
TFAP2C MCF7GSE21234 99691180 99691494 314 0
TFAP2C MCF7GSE21234 99793015 99793632 617 0
TFAP2C MCF7GSE21234 99803981 99804263 282 0
TFAP2C MCF7GSE21234 99863068 99863491 423 0
TFAP2C MCF7GSE21234 99996808 99997083 275 0
hScc1 BcellGSE12603 100078787 100079065 278 0
hScc1 BcellGSE12603 100087895 100088242 347 0
hScc1 BcellGSE12603 99541627 99542462 835 0
hScc1 BcellGSE12603 99881351 99881651 300 0
hScc1 BcellGSE12603 99887902 99888036 134 0
hScc1 CdLSGSE12603 99541627 99542509 882 0
hScc1 G2GSE9613 100078718 100079065 347 0
hScc1 G2GSE9613 99541627 99542509 882 0
p130 QuiescentGSE19898 99712145 99712325 180 0
p130 SenescentGSE19898 99645622 99646048 426 0
p130 shRbQuiescentGSE19898 99645579 99646112 533 0
p130 shRbSenescentGSE19898 99631980 99632136 156 0
p63 keratinocytesGSE17611 99684110 99685177 1067 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
14717 mRNA chr2 100179898 100182484 169 mRNA LAF4 chr2 99657964 100181108Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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