AutismKB 2.0

Annotation Detail for LAMC1


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Basic Information Top
Gene Symbol:LAMC1 ( LAMB2,MGC87297 )
Gene Full Name: laminin, gamma 1 (formerly LAMB2)
Band: 1q25.3
Quick LinksEntrez ID:3915; OMIM: 150290; Uniprot ID:LAMC1_HUMAN; ENSEMBL ID: ENSG00000135862; HGNC ID: 6492
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
60N-linked (GlcNAc...) (Potential).
134N-linked (GlcNAc...) (Potential).
576N-linked (GlcNAc...) (Potential).
650N-linked (GlcNAc...).
1022N-linked (GlcNAc...) (Potential).
1107N-linked (GlcNAc...).
1161N-linked (GlcNAc...).
1175N-linked (GlcNAc...).
1205N-linked (GlcNAc...) (Potential).
1223N-linked (GlcNAc...).
1241N-linked (GlcNAc...).
1380N-linked (GlcNAc...) (Potential).
1395N-linked (GlcNAc...).
1439N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
60N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
134N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
576N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
650N-linked (GlcNAc...).Swiss-Prot 53.0
1022N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1107N-linked (GlcNAc...).Swiss-Prot 53.0
1161N-linked (GlcNAc...).Swiss-Prot 53.0
1175N-linked (GlcNAc...).Swiss-Prot 53.0
1205N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1223N-linked (GlcNAc...).Swiss-Prot 53.0
1241N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1380N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1395N-linked (GlcNAc...).Swiss-Prot 53.0
1439N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
60N-linkedHMM predict
62O-linkedHMM predict
134N-linkedHMM predict
186Phosphotyrosine(SRC)HMM predict
274Phosphotyrosine(Syk)HMM predict
337Phosphoserine(IKK)HMM predict
352Phosphotyrosine(Syk)HMM predict
398S-palmitoylHMM predict
405Phosphoserine(CK1)HMM predict
426O-linkedHMM predict
495S-palmitoylHMM predict
554Phosphotyrosine(Jak)HMM predict
588Phosphothreonine(PKA)HMM predict
617O-linkedHMM predict
640Phosphothreonine(MAPK)HMM predict
650N-linkedHMM predict
712Phosphothreonine(PKA)HMM predict
766O-linkedHMM predict
846Phosphothreonine(PKA)HMM predict
896Phosphoserine(IKK)HMM predict
990Phosphoserine(CK1)HMM predict
1022N-linkedHMM predict
1107N-linkedHMM predict
1108N-linkedHMM predict
1161N-linkedHMM predict
1175N-linkedHMM predict
1205N-linkedHMM predict
1223N-linkedHMM predict
1307Phosphotyrosine(INSR)HMM predict
1380N-linkedHMM predict
1395N-linkedHMM predict
1439N-linkedHMM predict
1509Phosphoserine(PKG)HMM predict
1559Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002293
  • Location:chr1 181259175-181381348
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 181257601 181258551 950 1100
KLF4 hESGSE17917 181258837 181259056 219 229
PHF8 HeLaGSE20725 181258005 181260174 2169 86
TAF HelaGSE8489 181257326 181258470 1144 1278
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 181392113 181392769 656 11093
CTCF G2GSE9613 181385572 181385773 201 4324
NRSF mAbJurkat 181385572 181385773 201 4324
Oct1 HelaGSE14283 181387558 181387598 40 6230
Oct1 HelaGSE14283 181393980 181394041 61 12662
Oct1 HelaGSE14283 181394066 181394096 30 12733
P300 T30-glioblastomaGSE21026 181398687 181400629 1942 18310
Rb shRbQuiescentGSE19898 181384023 181384213 190 2770
TFAP2C MCF7GSE21234 181395734 181396415 681 14726
c MYCMCF7 181385572 181386019 447 4447
hScc1 BcellGSE12603 181385572 181385740 168 4308
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 181314791 181315409 618 0
CBP T30-glioblastomaGSE21026 181295893 181297224 1331 0
CBP T30-glioblastomaGSE21026 181375096 181375998 902 0
CTCF G2GSE9613 181259017 181260125 1108 0
CTCF G2GSE9613 181337705 181337950 245 0
ER Breast-CancerGSE22609 181259568 181260130 562 0
ER E2-MCF7GSE14664 181338501 181338535 34 0
ER E2-MCF7GSE14664 181339365 181339403 38 0
ER Fulvestrant-MCF7GSE14664 181338779 181338820 41 0
ER MCF7GSE19013 181258524 181260421 1897 0
FOXA1 MCF7GSE15244 181288528 181288973 445 0
FoxA1 MCF7MACSdata 181288596 181288925 329 0
FoxA1 MCF7MACSdata 181296169 181296559 390 0
FoxA1 MCF7MACSdata 181322784 181323017 233 0
H3ac HepG2E 181260053 181262170 2117 0
Nanog hESGSE18292 181333096 181333692 596 0
Oct1 H2O2-HelaGSE14283 181354841 181354879 38 0
Oct1 H2O2-HelaGSE14283 181356203 181356232 29 0
Oct1 HelaGSE14283 181271532 181271561 29 0
Oct1 HelaGSE14283 181278415 181278448 33 0
Oct1 HelaGSE14283 181285258 181285296 38 0
Oct1 HelaGSE14283 181296578 181296610 32 0
Oct1 HelaGSE14283 181330153 181330191 38 0
Oct1 HelaGSE14283 181339340 181339403 63 0
Oct1 HelaGSE14283 181354841 181354882 41 0
Oct1 HelaGSE14283 181371321 181371358 37 0
P300 T30-glioblastomaGSE21026 181295880 181296994 1114 0
P300 T30-glioblastomaGSE21026 181375106 181375946 840 0
PAX3-FKHR Rh4GSE19063 181261215 181262704 1489 0
PAX3-FKHR Rh4GSE19063 181345700 181346876 1176 0
RARA MCF7GSE15244 181296366 181297006 640 0
RNAII Tamoxifen-MCF7GSE14664 181339364 181339411 47 0
STAT1 HeLaGSE12783 181328530 181331284 2754 0
STAT1 IFNSISSRdata 181329357 181330779 1422 0
TFAP2C MCF7GSE21234 181287270 181287901 631 0
TFAP2C MCF7GSE21234 181296170 181296673 503 0
TFAP2C MCF7GSE21234 181322775 181323244 469 0
TFAP2C MCF7GSE21234 181329753 181330176 423 0
hScc1 BcellGSE12603 181258629 181259985 1356 0
p130 SenescentGSE19898 181275694 181276052 358 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-124 hsa-mir-124-1 8 17344415
hsa-miR-124 hsa-mir-124-2 8 17344415
hsa-miR-124 hsa-mir-124-3 20 17344415
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-124 hsa-mir-124-1 8 17344415
hsa-miR-124 hsa-mir-124-2 8 17344415
hsa-miR-124 hsa-mir-124-3 20 17344415
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-29a hsa-mir-29a 7 18390668
hsa-miR-29a hsa-mir-29a 7 18390668
hsa-miR-29a* hsa-mir-29a 7 18390668
hsa-miR-29a* hsa-mir-29a 7 18390668
hsa-miR-29b hsa-mir-29b-1 7 19956414
hsa-miR-29b hsa-mir-29b-2 1 19956414
hsa-miR-29b hsa-mir-29b-1 7 19956414
hsa-miR-29b hsa-mir-29b-2 1 19956414
hsa-miR-29b-1* hsa-mir-29b-1 7 19956414
hsa-miR-29b-1* hsa-mir-29b-1 7 19956414
hsa-miR-29c hsa-mir-29c 1 18390668
hsa-miR-29c hsa-mir-29c 1 18390668
hsa-miR-29c* hsa-mir-29c 1 18390668
hsa-miR-29c* hsa-mir-29c 1 18390668
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
420 mRNA cleavage TRUE miR-124 LAMC1 / laminin gamma n_a 16549876
592 Unknown TRUE miR-29c LAMC1 / laminin gamma Luciferase assay 18390668
1064 Unknown pSILAC miR-16 LAMC1 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000135862 G1-to-S transition n_a n_a "epithelium, squamous cell, lymphocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000135862 nasopharyngeal epithelium nasopharyngeal carcinomas (NPC) down regulated "epithelium, squamous cell, lymphocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000135862 n_a n_a n_a "epithelium, squamous cell, lymphocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
2045 mRNA LAMC1 chr1 179724209 179846384 148 EST chr1 179839192 179843579Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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