AutismKB 2.0

Annotation Detail for LASP1


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Basic Information Top
Gene Symbol:LASP1 ( Lasp-1,MLN50 )
Gene Full Name: LIM and SH3 protein 1
Band: 17q12
Quick LinksEntrez ID:3927; OMIM: 602920; Uniprot ID:LASP1_HUMAN; ENSEMBL ID: ENSG00000002834; HGNC ID: 6513
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
42N6-acetyllysine.
68Phosphothreonine.
104Phosphothreonine.
128N6-acetyllysine.
146Phosphoserine.
151Phosphoserine.
171Phosphotyrosine.
Location(AA) Modifications Resource
1N-acetylmethionine.Swiss-Prot 53.0
146Phosphoserine (PKA
171Phosphotyrosine.Swiss-Prot 53.0
171Phosphotyrosine (PKA
Location(AA) Modification Resource
68Phosphothreonine(MAPK)HMM predict
104Phosphothreonine(MAPK)HMM predict
146Phosphoserine(PKA)HMM predict
146Phosphoserine(IKK)HMM predict
146Phosphoserine(ATM)HMM predict
146Phosphoserine(CK1)HMM predict
146Phosphoserine(CAMK2)HMM predict
146Phosphoserine(PKG)HMM predict
151Phosphoserine(PKC)HMM predict
171Phosphotyrosine(SRC)HMM predict
171Phosphotyrosine(Abl)HMM predict
186Phosphotyrosine(INSR)HMM predict
186Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006148
  • Location:chr17 34279893-34331539
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me2 HCT116GSE10453 34273021 34273339 318 6714
H3ac HepG2E 34277794 34278937 1143 1528
LIN9 SGSE7516 34273021 34273339 318 6714
Pol3 GM12878GSE19551 34277254 34277852 598 2341
Pol3 GM12878GSE19551 34278838 34279366 528 792
hScc1 BcellGSE12603 34279507 34279949 442 166
p130 shRbSenescentGSE19898 34278683 34279040 357 1032
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 34333766 34333995 229 2341
CTCF CD4SISSRdata 34333766 34333995 229 2341
Myc K562GSE19551 34333731 34334009 278 2331
Oct1 HelaGSE14283 34335484 34335514 30 3960
p130 SenescentGSE19898 34335236 34335600 364 3879
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 34307165 34309876 2711 0
CTCF CD4GSE12889 34287296 34287506 210 0
CTCF CD4SISSRdata 34287296 34287506 210 0
CTCF G2GSE9613 34279574 34280469 895 0
CTCF G2GSE9613 34318469 34318795 326 0
ER MCF7GSE19013 34321973 34322427 454 0
Gata2 K562GSE18868 34304025 34304493 468 0
H3ac HepG2E 34279949 34280299 350 0
H3ac HepG2E 34280778 34282440 1662 0
H3ac HepG2E 34284051 34285544 1493 0
H3ac HepG2E 34288309 34288574 265 0
Myc K562GSE19551 34291188 34291664 476 0
NFkBII GM12892GSE19485 34318047 34319279 1232 0
P300 T0-glioblastomaGSE21026 34310318 34311227 909 0
P300 T30-glioblastomaGSE21026 34310269 34311440 1171 0
PHF8 HeLaGSE20725 34278926 34280931 2005 0
RARA MCF7GSE15244 34310466 34311250 784 0
RARA MCF7GSE15244 34321880 34322760 880 0
RARG MCF7GSE15244 34310466 34311250 784 0
RARG MCF7GSE15244 34321985 34322723 738 0
Rb SenescentGSE19898 34310809 34311181 372 0
Sox2 hESGSE18292 34293420 34293887 467 0
TFAP2C MCF7GSE21234 34283420 34284323 903 0
TFAP2C MCF7GSE21234 34285456 34285801 345 0
TFAP2C MCF7GSE21234 34325400 34325929 529 0
VDR GM10861-UnstimGSE22484 34307817 34309786 1969 0
hScc1 BcellGSE12603 34281365 34281722 357 0
hScc1 BcellGSE12603 34308506 34309055 549 0
hScc1 BcellGSE12603 34320818 34320967 149 0
hScc1 CdLSGSE12603 34279507 34280705 1198 0
p130 QuiescentGSE19898 34280044 34280408 364 0
p130 SenescentGSE19898 34307735 34308031 296 0
p130 shRbQuiescentGSE19898 34306125 34306630 505 0
p63 keratinocytesGSE17611 34318548 34319228 680 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-203 hsa-mir-203 14 21368580
hsa-miR-218 hsa-mir-218-1 4 19168627
hsa-miR-218 hsa-mir-218-2 5 19168627
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
176 Unknown MicroArray miR-1 LASP1 n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000002834 "cardiac and skeletal muscles, cardiogenesis" n_a n_a "epithelium, lymphoblast, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, non-Hodgkin's, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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