AutismKB 2.0

Annotation Detail for LCP2


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Basic Information Top
Gene Symbol:LCP2 ( SLP-76,SLP76 )
Gene Full Name: lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Band: 5q35.1
Quick LinksEntrez ID:3937; OMIM: 601603; Uniprot ID:LCP2_HUMAN; ENSEMBL ID: ENSG00000043462; HGNC ID: 6529
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
23Phosphotyrosine (By similarity).
173Phosphotyrosine.
207Phosphoserine.
Location(AA) Modifications Resource
113Phosphotyrosine (Syk;ZAP70;TX)Phospho.ELM 6.0
128Phosphotyrosine (Syk;ZAP70;TX)Phospho.ELM 6.0
145Phosphotyrosine (ZAP70;TXK)Phospho.ELM 6.0
173Phosphotyrosine.Swiss-Prot 53.0
173PhosphotyrosinePhospho.ELM 6.0
207Phosphoserine.Swiss-Prot 53.0
207PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
25MethyllysineHMM predict
26MethyllysineHMM predict
30MethyllysineHMM predict
48N-linkedHMM predict
52N-linkedHMM predict
69Phosphoserine(ATM)HMM predict
97Phosphoserine(CK1)HMM predict
97Phosphoserine(CK2)HMM predict
113Phosphotyrosine(INSR)HMM predict
113Phosphotyrosine(Syk)HMM predict
113Phosphotyrosine(EGFR)HMM predict
113Phosphotyrosine(SRC)HMM predict
113PhosphotyrosineHMM predict
113SulfotyrosineHMM predict
115Phosphoserine(ATM)HMM predict
128Phosphotyrosine(Syk)HMM predict
128SulfotyrosineHMM predict
128PhosphotyrosineHMM predict
128Phosphotyrosine(INSR)HMM predict
128Phosphotyrosine(EGFR)HMM predict
130Phosphoserine(ATM)HMM predict
145Phosphotyrosine(EGFR)HMM predict
145SulfotyrosineHMM predict
145Phosphotyrosine(INSR)HMM predict
145Phosphotyrosine(Syk)HMM predict
182Phosphothreonine(CDK)HMM predict
182Phosphothreonine(CDC2)HMM predict
205N-linkedHMM predict
207O-linkedHMM predict
207Phosphoserine(CDC2)HMM predict
207Phosphoserine(CDK)HMM predict
207Phosphoserine(IKK)HMM predict
214O-linkedHMM predict
220Phosphoserine(CK1)HMM predict
264Phosphoserine(ATM)HMM predict
346O-linkedHMM predict
350Phosphoserine(CDC2)HMM predict
357O-linkedHMM predict
368N-linkedHMM predict
370Phosphoserine(IKK)HMM predict
382Phosphoserine(ATM)HMM predict
410Phosphoserine(CDC2)HMM predict
410PhosphoserineHMM predict
410Phosphoserine(IKK)HMM predict
417Phosphoserine(CK1)HMM predict
459Phosphotyrosine(SRC)HMM predict
497Phosphoserine(CK2)HMM predict
522Phosphotyrosine(EGFR)HMM predict
524CysteineHMM predict
524S-farnesylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005565
  • Location:chr5 169607666-169657399
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 169666969 169667806 837 9988
CTCF G2GSE9613 169662342 169662729 387 5136
CTCF G2GSE9613 169669011 169669397 386 11805
P300 T30-glioblastomaGSE21026 169666943 169667815 872 9980
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
RARA MCF7GSE15244 169605914 169607236 1322 1092
TFAP2C MCF7GSE21234 169606082 169606544 462 1354
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 169637534 169639797 2263 0
CTCF G2GSE9613 169627464 169627786 322 0
CTCF G2GSE9613 169656220 169656555 335 0
FOXA1 MCF7GSE15244 169632954 169634059 1105 0
FoxA1 MCF7MACSdata 169633478 169633764 286 0
RUNX JurkatGSE17954 169638042 169638285 243 0
Rb QuiescentGSE19898 169626734 169626867 133 0
TFAP2C MCF7GSE21234 169632646 169633113 467 0
TFAP2C MCF7GSE21234 169633258 169633873 615 0
hScc1 BcellGSE12603 169627427 169627786 359 0
hScc1 CdLSGSE12603 169626968 169627827 859 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
21821 mRNA LOC133874 chr5 169592523 169612151 78 mRNA LCP2 chr5 169607666 169657400Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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