AutismKB 2.0

Annotation Detail for LCT


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Basic Information Top
Gene Symbol:LCT ( LAC,LPH,LPH1 )
Gene Full Name: lactase
Band: 2q21.3
Quick LinksEntrez ID:3938; OMIM: 603202; Uniprot ID:LPH_HUMAN; ENSEMBL ID: ENSG00000115850; HGNC ID: 6530
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1303Phosphotyrosine.
1313Phosphotyrosine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
62Phosphotyrosine(Jak)HMM predict
62Phosphotyrosine(EGFR)HMM predict
82Phosphoserine(ATM)HMM predict
140Phosphothreonine(PKC)HMM predict
190Phosphoserine(IKK)HMM predict
206SulfotyrosineHMM predict
269Phosphothreonine(PKC)HMM predict
324Phosphoserine(CDC2)HMM predict
325Phosphoserine(CDC2)HMM predict
326O-linkedHMM predict
331Phosphoserine(IKK)HMM predict
337Phosphoserine(IKK)HMM predict
353Phosphoserine(IKK)HMM predict
354Phosphoserine(CDK)HMM predict
368N-linkedHMM predict
418N-linkedHMM predict
468O-linkedHMM predict
470O-linkedHMM predict
610Phosphoserine(MAPK)HMM predict
610Phosphoserine(CDC2)HMM predict
692Phosphoserine(PKG)HMM predict
710Phosphoserine(ATM)HMM predict
751Phosphotyrosine(Jak)HMM predict
778Phosphotyrosine(INSR)HMM predict
821N-linkedHMM predict
830Phosphothreonine(CDK)HMM predict
830Phosphothreonine(PKC)HMM predict
830Phosphothreonine(MAPK)HMM predict
830Phosphothreonine(CDC2)HMM predict
934N-linkedHMM predict
946N-linkedHMM predict
989N-linkedHMM predict
990Phosphoserine(PKG)HMM predict
991Phosphoserine(PKB)HMM predict
993N-linkedHMM predict
1125Phosphoserine(CK1)HMM predict
1133Phosphoserine(CDC2)HMM predict
1174N-linkedHMM predict
1188Phosphoserine(PKB)HMM predict
1226SulfotyrosineHMM predict
1239Phosphoserine(IKK)HMM predict
1253Phosphothreonine(PKC)HMM predict
1295Phosphotyrosine(INSR)HMM predict
1340N-linkedHMM predict
1341N-linkedHMM predict
1343N-linkedHMM predict
1347Phosphothreonine(PKC)HMM predict
1351Phosphoserine(PKG)HMM predict
1374Phosphotyrosine(EGFR)HMM predict
1412Phosphothreonine(MAPK)HMM predict
1464Phosphotyrosine(INSR)HMM predict
1473Phosphotyrosine(EGFR)HMM predict
1508N-linkedHMM predict
1518Phosphotyrosine(Syk)HMM predict
1656N-linkedHMM predict
1664Phosphothreonine(CK2)HMM predict
1672N-linkedHMM predict
1713Phosphoserine(IKK)HMM predict
1740Phosphotyrosine(Syk)HMM predict
1746Phosphotyrosine(INSR)HMM predict
1753Phosphoserine(ATM)HMM predict
1761N-linkedHMM predict
1772Phosphotyrosine(INSR)HMM predict
1814N-linkedHMM predict
1859O-linkedHMM predict
1861Phosphoserine(CDC2)HMM predict
1896S-palmitoylHMM predict
1922Phosphoserine(ATM)HMM predict
1922Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002299
  • Location:chr2 136261884-136311219
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
P300 T30-glioblastomaGSE21026 136260700 136261610 910 730
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 136298649 136302058 3409 0
CTCF CD4GSE12889 136271611 136271890 279 0
CTCF CD4SISSRdata 136271611 136271890 279 0
CTCF JurkatGSE12889 136271578 136271865 287 0
CTCF G2GSE9613 136270682 136270943 261 0
CTCF G2GSE9613 136271431 136272134 703 0
CTCF G2GSE9613 136274790 136275427 637 0
CTCF G2GSE9613 136279486 136279664 178 0
CTCF G2GSE9613 136293247 136293678 431 0
CTCF G2GSE9613 136305218 136305367 149 0
ER Fulvestrant-MCF7GSE14664 136302546 136302594 48 0
KLF4 hESGSE17917 136268832 136269081 249 0
Myc K562GSE19551 136271556 136272001 445 0
Oct1 HelaGSE14283 136302552 136302592 40 0
hScc1 BcellGSE12603 136280892 136281160 268 0
p130 SenescentGSE19898 136293493 136293632 139 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-125a-3p hsa-mir-125a 19 20569443
hsa-miR-125a-5p hsa-mir-125a 19 20569443
hsa-miR-143 hsa-mir-143 5 20363096
hsa-miR-143* hsa-mir-143 5 20363096
hsa-miR-181a hsa-mir-181a-2 9 20363096
hsa-miR-181a hsa-mir-181a-1 1 20363096
hsa-miR-181a* hsa-mir-181a-1 1 20363096
hsa-miR-21 hsa-mir-21 17 20363096
hsa-miR-21* hsa-mir-21 17 20363096
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
15060 mRNA chr2 136411492 136414389 79 mRNA LCT chr2 136379146 136428482Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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