AutismKB 2.0

Annotation Detail for LHX1


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Basic Information Top
Gene Symbol:LHX1 ( LIM-1,LIM1,MGC126723,MGC138141 )
Gene Full Name: LIM homeobox 1
Band: 17q12
Quick LinksEntrez ID:3975; OMIM: 601999; Uniprot ID:LHX1_HUMAN; ENSEMBL ID: ENSG00000132130; HGNC ID: 6593
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
37N-linkedHMM predict
50Phosphotyrosine(INSR)HMM predict
81Phosphoserine(PKB)HMM predict
100Phosphothreonine(CK2)HMM predict
121N-linkedHMM predict
129Phosphoserine(CK1)HMM predict
140O-linkedHMM predict
142Phosphoserine(CDC2)HMM predict
142Phosphoserine(MAPK)HMM predict
145Phosphoserine(IKK)HMM predict
145Phosphoserine(ATM)HMM predict
149Phosphoserine(ATM)HMM predict
186Phosphothreonine(PKC)HMM predict
202Phosphothreonine(MAPK)HMM predict
202O-linkedHMM predict
254Phosphoserine(CDC2)HMM predict
282SulfotyrosineHMM predict
286Phosphotyrosine(Syk)HMM predict
302O-linkedHMM predict
303O-linkedHMM predict
303O-linkedHMM predict
303Phosphoserine(ATM)HMM predict
307Phosphothreonine(MAPK)HMM predict
316O-linkedHMM predict
317O-linkedHMM predict
317Phosphoserine(ATM)HMM predict
317O-linkedHMM predict
320O-linkedHMM predict
344Phosphothreonine(PKA)HMM predict
354Phosphoserine(CDC2)HMM predict
356Phosphoserine(ATM)HMM predict
356Phosphoserine(IKK)HMM predict
356O-linkedHMM predict
360O-linkedHMM predict
360Phosphoserine(CK1)HMM predict
367Phosphoserine(MAPK)HMM predict
376Phosphoserine(CDC2)HMM predict
376O-linkedHMM predict
380O-linkedHMM predict
403AlanineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005568
  • Location:chr17 32368611-32374606
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 32352897 32353398 501 15464
H3K27me3 colorectalcancer 32361131 32363721 2590 6186
H3K27me3 colorectalcancer 32364010 32364664 654 4275
H3K27me3 colorectalcancer 32364906 32365780 874 3269
H3K27me3 colorectalcancer 32366651 32367807 1156 1383
Nanog hESGSE18292 32360104 32360632 528 8244
Sox2 hESGSE18292 32360214 32360645 431 8182
TFAP2C MCF7GSE21234 32349604 32350452 848 18584
TFAP2C MCF7GSE21234 32351175 32351926 751 17061
TFAP2C MCF7GSE21234 32352086 32352464 378 16337
hScc1 BcellGSE12603 32362595 32362879 284 5875
hScc1 BcellGSE12603 32367734 32368427 693 531
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 32369014 32369859 845 0
H3K27me3 colorectalcancer 32372912 32373339 427 0
TFAP2C MCF7GSE21234 32369519 32370468 949 0
hScc1 BcellGSE12603 32369287 32370535 1248 0
hScc1 BcellGSE12603 32371774 32372196 422 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-30a hsa-mir-30a 6 19906860
hsa-miR-30a* hsa-mir-30a 6 19906860
hsa-miR-30b hsa-mir-30b 8 19906860
hsa-miR-30b* hsa-mir-30b 8 19906860
hsa-miR-30c hsa-mir-30c-2 6 19906860
hsa-miR-30c hsa-mir-30c-1 1 19906860
hsa-miR-30c-1* hsa-mir-30c-1 1 19906860
hsa-miR-30c-2* hsa-mir-30c-2 6 19906860
hsa-miR-30d hsa-mir-30d 8 19906860
hsa-miR-30d* hsa-mir-30d 8 19906860
hsa-miR-30e hsa-mir-30e 1 19906860
hsa-miR-30e* hsa-mir-30e 1 19906860
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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