AutismKB 2.0

Annotation Detail for LIFR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LIFR ( CD118,FLJ98106,FLJ99923,LIF-R,SJS2,STWS,SWS )
Gene Full Name: leukemia inhibitory factor receptor alpha
Band: 5p13.1
Quick LinksEntrez ID:3977; OMIM: 151443; Uniprot ID:LIFR_HUMAN; ENSEMBL ID: ENSG00000113594; HGNC ID: 6597
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
64N-linked (GlcNAc...) (Potential).
85N-linked (GlcNAc...) (Potential).
131N-linked (GlcNAc...).
143N-linked (GlcNAc...) (Potential).
191N-linked (GlcNAc...) (Potential).
243N-linked (GlcNAc...) (Potential).
303N-linked (GlcNAc...).
390N-linked (GlcNAc...) (Potential).
407N-linked (GlcNAc...).
426N-linked (GlcNAc...).
445N-linked (GlcNAc...) (Potential).
481N-linked (GlcNAc...) (Potential).
489N-linked (GlcNAc...) (Potential).
523WSXWS motif.
572N-linked (GlcNAc...) (Potential).
652N-linked (GlcNAc...) (Potential).
663N-linked (GlcNAc...) (Potential).
680N-linked (GlcNAc...) (Potential).
729N-linked (GlcNAc...) (Potential).
787N-linked (GlcNAc...) (Potential).
877Box 1 motif.
927Phosphoserine.
Location(AA) Modifications Resource
64N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
85N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
131N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
143N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
191N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
243N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
303N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
390N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
407N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
426N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
445N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
481N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
489N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
572N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
652N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
663N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
680N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
729N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
787N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1044Phosphoserine (MAPK1;MAPK3;)Phospho.ELM 6.0
Location(AA) Modification Resource
12Phosphoserine(PKA)HMM predict
85N-linkedHMM predict
122Phosphothreonine(PKC)HMM predict
131N-linkedHMM predict
191N-linkedHMM predict
195N-linkedHMM predict
235C-linkedHMM predict
243N-linkedHMM predict
271S-palmitoylHMM predict
305Phosphoserine(CAMK2)HMM predict
307O-linkedHMM predict
335Phosphothreonine(MAPK)HMM predict
368Phosphoserine(PKB)HMM predict
407N-linkedHMM predict
411N-linkedHMM predict
426N-linkedHMM predict
435Phosphothreonine(MAPK)HMM predict
437Phosphothreonine(MAPK)HMM predict
445N-linkedHMM predict
473Phosphoserine(PKG)HMM predict
481N-linkedHMM predict
534Phosphoserine(CDC2)HMM predict
534PhosphoserineHMM predict
536O-linkedHMM predict
572N-linkedHMM predict
577Phosphoserine(CK1)HMM predict
583Phosphoserine(CK1)HMM predict
615O-linkedHMM predict
616Phosphoserine(ATM)HMM predict
616Phosphoserine(CDC2)HMM predict
616Phosphoserine(CDK)HMM predict
652N-linkedHMM predict
663N-linkedHMM predict
680N-linkedHMM predict
729N-linkedHMM predict
770Phosphothreonine(PKA)HMM predict
787N-linkedHMM predict
870Phosphotyrosine(EGFR)HMM predict
904Phosphothreonine(CDC2)HMM predict
927Phosphoserine(MAPK)HMM predict
974Phosphotyrosine(Jak)HMM predict
1010N-linkedHMM predict
1041Phosphoserine(CDC2)HMM predict
1044Phosphoserine(CDC2)HMM predict
1050Phosphoserine(CK2)HMM predict
1077Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002310
  • Location:chr5 38510822-38631252
  • strand:-
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 38587383 38587577 194 0
CTCF CD4SISSRdata 38587383 38587577 194 0
CTCF G2GSE9613 38519863 38520133 270 0
CTCF G2GSE9613 38533947 38534310 363 0
CTCF G2GSE9613 38587020 38587770 750 0
CTCF G2GSE9613 38591754 38592910 1156 0
CTCF G2GSE9613 38623068 38623318 250 0
CTCF G2GSE9613 38630832 38631263 431 0
ER E2-MCF7GSE14664 38565863 38565912 49 0
ER E2-MCF7GSE14664 38591050 38591136 86 0
Oct1 H2O2-HelaGSE14283 38556765 38556797 32 0
Oct1 HelaGSE14283 38547915 38547955 40 0
Oct1 HelaGSE14283 38556765 38556797 32 0
Oct1 HelaGSE14283 38587999 38588035 36 0
Oct1 HelaGSE14283 38591004 38591071 67 0
Oct1 HelaGSE14283 38608535 38608655 120 0
Oct1 HelaGSE14283 38614265 38614296 31 0
P300 T30-glioblastomaGSE21026 38585420 38586312 892 0
PHF8 HeLaGSE20725 38591687 38593532 1845 0
RNAII Tamoxifen-MCF7GSE14664 38547925 38547959 34 0
TAF HelaGSE8489 38573304 38573502 198 0
TAF HelaGSE8489 38590644 38591876 1232 0
TAF HelaGSE8489 38593049 38593566 517 0
TAF HelaGSE8489 38613589 38613881 292 0
TAFII hESGSE17917 38551574 38551788 214 0
TFAP2C MCF7GSE21234 38569516 38569804 288 0
hScc1 BcellGSE12603 38587134 38587679 545 0
hScc1 BcellGSE12603 38591950 38592376 426 0
hScc1 CdLSGSE12603 38591924 38592376 452 0
hScc1 G2GSE9613 38533947 38534384 437 0
hScc1 G2GSE9613 38587091 38587644 553 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20873 mRNA chr5 38592644 38644714 38609 mRNA LIFR chr5 38515661 38631253 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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