AutismKB 2.0

Annotation Detail for LIMK1


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Basic Information Top
Gene Symbol:LIMK1 ( LIMK )
Gene Full Name: LIM domain kinase 1
Band: 7q11.23
Quick LinksEntrez ID:3984; OMIM: 601329; Uniprot ID:LIMK1_HUMAN; ENSEMBL ID: ENSG00000106683; HGNC ID: 6613
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
210Phosphoserine.
229Phosphothreonine.
261Phosphothreonine.
270Phosphothreonine.
296Phosphoserine.
298Phosphoserine.
302Phosphoserine.
307Phosphoserine.
310Phosphoserine.
313Phosphoserine.
337Phosphoserine.
508Phosphothreonine; by ROCK1.
Location(AA) Modifications Resource
298Phosphoserine.Swiss-Prot 53.0
310Phosphoserine.Swiss-Prot 53.0
508Phosphothreonine (by ROCK1).Swiss-Prot 53.0
508Phosphothreonine (PAK1;ROCK
Location(AA) Modification Resource
7S-palmitoylHMM predict
8S-palmitoylHMM predict
52S-palmitoylHMM predict
53S-palmitoylHMM predict
63Phosphotyrosine(Syk)HMM predict
64Phosphotyrosine(Syk)HMM predict
124Phosphotyrosine(INSR)HMM predict
139Phosphotyrosine(Syk)HMM predict
154Phosphoserine(ATM)HMM predict
157O-linkedHMM predict
227N-linkedHMM predict
229Phosphothreonine(CDC2)HMM predict
233N-linkedHMM predict
271O-linkedHMM predict
274O-linkedHMM predict
275O-linkedHMM predict
275Phosphoserine(CDC2)HMM predict
279Phosphothreonine(MAPK)HMM predict
279PhosphothreonineHMM predict
310Phosphoserine(IKK)HMM predict
313Phosphoserine(ATM)HMM predict
323Phosphoserine(PKA)HMM predict
435Phosphoserine(ATM)HMM predict
526Phosphotyrosine(EGFR)HMM predict
596Phosphoserine(PKA)HMM predict
637Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002314
  • Location:chr7 73136091-73174789
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 73131209 73132166 957 4404
CTCF G2GSE9613 73135287 73135615 328 641
P300 T30-glioblastomaGSE21026 73131079 73132291 1212 4407
PHF8 293TGSE20725 73135220 73135982 762 491
p130 shRbQuiescentGSE19898 73135402 73135892 490 445
p63 keratinocytesGSE17611 73131157 73132087 930 4470
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Breast-CancerGSE22609 73185987 73186340 353 11374
ER Breast-CancerGSE22609 73191874 73192106 232 17201
Nanog hESGSE18292 73191391 73191615 224 16714
Oct1 H2O2-HelaGSE14283 73180233 73180263 30 5459
Oct1 HelaGSE14283 73185560 73185589 29 10785
STAT1 HeLaGSE12782 73185829 73187570 1741 11910
STAT1 HeLaGSE12782 73192588 73194746 2158 18878
STAT1 HeLaGSE12783 73185610 73187536 1926 11784
STAT1 HeLaGSE12783 73192622 73195006 2384 19025
STAT1 IFNSISSRdata 73185906 73186997 1091 11662
STAT1 IFNSISSRdata 73192625 73193566 941 18306
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 73137719 73138192 473 0
CTCF G2GSE9613 73141813 73142118 305 0
CTCF G2GSE9613 73143920 73144109 189 0
CTCF G2GSE9613 73144815 73145054 239 0
CTCF G2GSE9613 73146256 73146979 723 0
CTCF G2GSE9613 73147984 73148192 208 0
CTCF G2GSE9613 73150620 73150800 180 0
CTCF G2GSE9613 73159148 73159352 204 0
CTCF G2GSE9613 73159984 73160251 267 0
CTCF G2GSE9613 73160957 73161209 252 0
CTCF G2GSE9613 73167717 73168313 596 0
CTCF G2GSE9613 73173031 73174178 1147 0
ER E2-MCF7GSE14664 73172619 73172667 48 0
Fos K562GSE19551 73136689 73137146 457 0
Fos K562GSE19551 73146216 73146855 639 0
Oct1 H2O2-HelaGSE14283 73172622 73172666 44 0
Oct1 HelaGSE14283 73172621 73172663 42 0
Rb GrowingGSE19898 73136808 73136990 182 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-134 hsa-mir-134 14 16488859
hsa-miR-134 hsa-mir-134 14 16421561
hsa-miR-138 hsa-mir-138-2 16 20064393
hsa-miR-138 hsa-mir-138-1 3 20064393
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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