AutismKB 2.0

Annotation Detail for LOXL2


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Basic Information Top
Gene Symbol:LOXL2 ( LOR2,WS9-14 )
Gene Full Name: lysyl oxidase-like 2
Band: 8p21.3
Quick LinksEntrez ID:4017; OMIM: 606663; Uniprot ID:LOXL2_HUMAN; ENSEMBL ID: ENSG00000134013; HGNC ID: 6666
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
288N-linked (GlcNAc...) (Potential).
455N-linked (GlcNAc...) (Potential).
644N-linked (GlcNAc...) (Potential).
6892',4',5'-topaquinone (By similarity).
Location(AA) Modifications Resource
288N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
455N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
644N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
653Lysine tyrosylquinone (Lys-Tyr) (Bysimilarity).Swiss-Prot 53.0
6892',4',5'-topaquinone (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
20Phosphoserine(MAPK)HMM predict
36SulfotyrosineHMM predict
44Phosphotyrosine(Abl)HMM predict
89Phosphoserine(CK1)HMM predict
107O-linkedHMM predict
112Phosphoserine(CDC2)HMM predict
199Phosphothreonine(PKA)HMM predict
242Phosphotyrosine(EGFR)HMM predict
252Phosphoserine(PKC)HMM predict
288N-linkedHMM predict
293N-linkedHMM predict
308Phosphoserine(CDC2)HMM predict
319Phosphotyrosine(Jak)HMM predict
333Phosphotyrosine(INSR)HMM predict
426Phosphothreonine(PKA)HMM predict
455N-linkedHMM predict
593Phosphotyrosine(Jak)HMM predict
644N-linkedHMM predict
725Phosphotyrosine(INSR)HMM predict
726Phosphoserine(IKK)HMM predict
763PhenylalanineHMM predict
764PhenylalanineHMM predict
765PhenylalanineHMM predict
766PhenylalanineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002318
  • Location:chr8 23210354-23317666
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 23323802 23324198 396 6334
CTCF CD4SISSRdata 23323802 23324198 396 6334
CTCF HelaGSE12889 23323847 23324207 360 6361
CTCF JurkatGSE12889 23323886 23324151 265 6352
CTCF G2GSE9613 23321540 23321783 243 3995
CTCF G2GSE9613 23323752 23324266 514 6343
CTCF G2GSE9613 23329255 23329953 698 11938
ER Breast-CancerGSE22609 23331179 23331826 647 13836
Myc K562GSE19551 23323754 23324251 497 6336
Oct4 hESGSE17917 23323884 23324136 252 6344
TAFII hESGSE17917 23323881 23324268 387 6408
hScc1 BcellGSE12603 23323752 23324266 514 6343
hScc1 CdLSGSE12603 23323752 23324266 514 6343
hScc1 G2GSE9613 23323752 23324371 619 6395
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 23201271 23201656 385 8891
CTCF CD4GSE12889 23209670 23209933 263 553
CTCF CD4SISSRdata 23201271 23201656 385 8891
CTCF CD4SISSRdata 23209670 23209933 263 553
CTCF HelaGSE12889 23201333 23201584 251 8896
CTCF JurkatGSE12889 23201218 23201717 499 8887
CTCF G2GSE9613 23201079 23202141 1062 8745
CTCF G2GSE9613 23203566 23204036 470 6554
CTCF G2GSE9613 23205036 23205480 444 5097
CTCF G2GSE9613 23207863 23208168 305 2339
CTCF G2GSE9613 23209171 23210125 954 707
Myc K562GSE19551 23201216 23201808 592 8843
NRSF pAbJurkat 23203313 23204281 968 6558
P300 T0-glioblastomaGSE21026 23201298 23201783 485 8814
PHF8 293TGSE20725 23201225 23202290 1065 8597
PHF8 HeLaGSE20725 23201173 23202226 1053 8655
VDR GM10861-UnstimGSE22484 23200864 23202210 1346 8818
VDR GM10861-stimGSE22484 23200924 23202052 1128 8867
hScc1 BcellGSE12603 23198167 23198400 233 12071
hScc1 BcellGSE12603 23209344 23210089 745 638
hScc1 CdLSGSE12603 23201404 23201757 353 8774
hScc1 G2GSE9613 23201032 23201724 692 8977
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 23295156 23295310 154 0
CTCF CD4SISSRdata 23295156 23295310 154 0
CTCF HelaGSE12889 23233525 23233757 232 0
CTCF G2GSE9613 23211112 23211670 558 0
CTCF G2GSE9613 23216254 23217658 1404 0
CTCF G2GSE9613 23222754 23223496 742 0
CTCF G2GSE9613 23228339 23228582 243 0
CTCF G2GSE9613 23229722 23230023 301 0
CTCF G2GSE9613 23232886 23234051 1165 0
CTCF G2GSE9613 23237793 23238101 308 0
CTCF G2GSE9613 23240225 23240402 177 0
CTCF G2GSE9613 23241738 23242059 321 0
CTCF G2GSE9613 23252171 23252373 202 0
CTCF G2GSE9613 23253070 23253505 435 0
CTCF G2GSE9613 23257039 23257467 428 0
CTCF G2GSE9613 23316672 23317819 1147 0
FOXA1 MCF7GSE15244 23269807 23270490 683 0
FOXA1 MCF7GSE15244 23304958 23305777 819 0
GATA3 MCF7GSE15244 23267150 23267775 625 0
GATA3 MCF7GSE15244 23305352 23305777 425 0
KLF4 hESGSE17917 23246798 23247145 347 0
NFkBII GM12892GSE19485 23248969 23250218 1249 0
NRSF pAbJurkat 23212135 23212975 840 0
NRSF pAbJurkat 23252883 23253244 361 0
Nanog hESGSE18292 23267373 23267792 419 0
Oct1 H2O2-HelaGSE14283 23276992 23277021 29 0
Oct1 H2O2-HelaGSE14283 23297426 23297461 35 0
Oct1 HelaGSE14283 23231008 23231087 79 0
Oct1 HelaGSE14283 23276990 23277021 31 0
Oct1 HelaGSE14283 23278860 23278893 33 0
Oct1 HelaGSE14283 23279929 23279967 38 0
Oct1 HelaGSE14283 23281034 23281067 33 0
RARA MCF7GSE15244 23266788 23268152 1364 0
RARA MCF7GSE15244 23269807 23270247 440 0
RARG MCF7GSE15244 23237464 23237685 221 0
RARG MCF7GSE15244 23267174 23267909 735 0
RARG MCF7GSE15244 23269807 23270490 683 0
RARG MCF7GSE15244 23304958 23305704 746 0
Rb GrowingGSE19898 23257125 23257301 176 0
Rb GrowingGSE19898 23258223 23258632 409 0
Rb SenescentGSE19898 23258871 23259117 246 0
Sox2 hESGSE18292 23267470 23267688 218 0
TFAP2C MCF7GSE21234 23217276 23217958 682 0
TFAP2C MCF7GSE21234 23239283 23239734 451 0
TFAP2C MCF7GSE21234 23262914 23263284 370 0
TFAP2C MCF7GSE21234 23267274 23267846 572 0
TFAP2C MCF7GSE21234 23269466 23269873 407 0
hScc1 BcellGSE12603 23248970 23249655 685 0
hScc1 BcellGSE12603 23295159 23295388 229 0
hScc1 BcellGSE12603 23316600 23317320 720 0
p130 SenescentGSE19898 23258720 23259106 386 0
p130 shRbSenescentGSE19898 23276836 23277128 292 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
25176 HTC chr8 23249628 23254994 178 mRNA LOXL2 chr8 23210640 23317575Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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