AutismKB 2.0

Annotation Detail for LRP5


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Basic Information Top
Gene Symbol:LRP5 ( BMND1,EVR1,EVR4,HBM,LR3,LRP7,OPPG,OPS,OPTA1,VBCH2 )
Gene Full Name: low density lipoprotein receptor-related protein 5
Band: 11q13.2
Quick LinksEntrez ID:4041; OMIM: 603506; Uniprot ID:LRP5_HUMAN; ENSEMBL ID: ENSG00000162337; HGNC ID: 6697
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
93N-linked (GlcNAc...) (Potential).
138N-linked (GlcNAc...) (Potential).
446N-linked (GlcNAc...) (Potential).
499N-linked (GlcNAc...) (Potential).
705N-linked (GlcNAc...) (Potential).
878N-linked (GlcNAc...) (Potential).
1506PPPSP motif A.
1545PPPSP motif B.
1581PPPSP motif C.
1596PPPSP motif D.
1612PPPSP motif E.
Location(AA) Modifications Resource
93N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
138N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
446N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
499N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
705N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
878N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
23S-palmitoylHMM predict
25S-palmitoylHMM predict
32Phosphoserine(MAPK)HMM predict
93N-linkedHMM predict
109Phosphoserine(CDK)HMM predict
109Phosphoserine(MAPK)HMM predict
138N-linkedHMM predict
164Phosphotyrosine(Jak)HMM predict
173Phosphothreonine(CDC2)HMM predict
313Phosphoserine(MAPK)HMM predict
313Phosphoserine(CDC2)HMM predict
320O-linkedHMM predict
356Phosphoserine(PKG)HMM predict
356Phosphoserine(CAMK2)HMM predict
386Phosphotyrosine(Jak)HMM predict
446N-linkedHMM predict
705N-linkedHMM predict
719SulfotyrosineHMM predict
774Phosphotyrosine(Jak)HMM predict
878N-linkedHMM predict
940N-linkedHMM predict
942Phosphoserine(ATM)HMM predict
951Phosphoserine(ATM)HMM predict
1017Phosphoserine(ATM)HMM predict
1138PhosphoserineHMM predict
1357Phosphoserine(IKK)HMM predict
1380Phosphoserine(IKK)HMM predict
1380PhosphoserineHMM predict
1428O-linkedHMM predict
1443Phosphoserine(ATM)HMM predict
1460Phosphoserine(ATM)HMM predict
1484O-linkedHMM predict
1485Phosphoserine(CK1)HMM predict
1487Phosphoserine(CK1)HMM predict
1487O-linkedHMM predict
1487Phosphoserine(CDC2)HMM predict
1488Phosphoserine(CK1)HMM predict
1492O-linkedHMM predict
1503O-linkedHMM predict
1503Phosphoserine(MAPK)HMM predict
1503Phosphoserine(CDC2)HMM predict
1524O-linkedHMM predict
1541Phosphothreonine(MAPK)HMM predict
1553Phosphoserine(CK1)HMM predict
1563Phosphotyrosine(Syk)HMM predict
1570Phosphoserine(ATM)HMM predict
1573Phosphotyrosine(Syk)HMM predict
1578Phosphothreonine(MAPK)HMM predict
1583Phosphotyrosine(Syk)HMM predict
1589Phosphoserine(IKK)HMM predict
1589O-linkedHMM predict
1593Phosphoserine(CDC2)HMM predict
1593Phosphoserine(MAPK)HMM predict
1593PhosphoserineHMM predict
1596Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002335
  • Location:chr11 67836710-67973316
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 67821857 67822076 219 14744
CTCF CD4SISSRdata 67821857 67822076 219 14744
CTCF JurkatGSE12889 67821892 67822151 259 14689
FOXA1 DLD1GSE12801 67822022 67822580 558 14410
FOXA1 MCF7GSE15244 67821833 67822385 552 14602
H3ac HepG2E 67822349 67823589 1240 13742
hScc1 BcellGSE12603 67820526 67821281 755 15807
hScc1 BcellGSE12603 67821797 67822612 815 14506
hScc1 CdLSGSE12603 67821797 67822488 691 14568
hScc1 G2GSE9613 67821797 67822022 225 14801
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 67904101 67905063 962 0
CBP T30-glioblastomaGSE21026 67877686 67879152 1466 0
CBP T30-glioblastomaGSE21026 67904115 67905605 1490 0
CTCF CD4GSE12889 67907868 67908336 468 0
CTCF CD4GSE12889 67971242 67971609 367 0
CTCF CD4SISSRdata 67907868 67908336 468 0
CTCF CD4SISSRdata 67971242 67971609 367 0
CTCF JurkatGSE12889 67908089 67908243 154 0
CTCF JurkatGSE12889 67971324 67971611 287 0
ER E2-MCF7GSE14664 67840031 67840068 37 0
ER Fulvestrant-MCF7GSE14664 67840017 67840069 52 0
ER MCF7GSE19013 67865181 67865801 620 0
ER MCF7GSE19013 67904252 67904676 424 0
FOXA1 DLD1GSE12801 67845394 67845700 306 0
FOXA1 DLD1GSE12801 67864686 67865430 744 0
FOXA1 DLD1GSE12801 67904615 67904916 301 0
FOXA1 MCF7GSE15244 67837577 67838799 1222 0
FOXA1 MCF7GSE15244 67851508 67852015 507 0
FOXA1 MCF7GSE15244 67861221 67861622 401 0
FOXA1 MCF7GSE15244 67871131 67872168 1037 0
FOXA1 MCF7GSE15244 67876535 67877097 562 0
FOXA1 MCF7GSE15244 67878594 67879324 730 0
FOXA1 MCF7GSE15244 67904615 67904916 301 0
FOXA1 MCF7GSE15244 67912982 67914062 1080 0
FOXA1 MCF7GSE15244 67930294 67931188 894 0
FOXA1 MCF7GSE15244 67937095 67938625 1530 0
FOXA1 MCF7GSE15244 67971804 67971970 166 0
FoxA1 MCF7MACSdata 67904169 67904730 561 0
H3ac HepG2E 67837376 67839805 2429 0
H3ac HepG2E 67851297 67855606 4309 0
H3ac HepG2E 67856611 67857613 1002 0
H3ac HepG2E 67864686 67865430 744 0
KLF4 hESGSE17917 67887975 67888139 164 0
NRSF pAbJurkat 67845394 67845666 272 0
NRSF pAbJurkat 67858304 67858599 295 0
NRSF pAbJurkat 67861622 67861851 229 0
NRSF pAbJurkat 67866088 67866575 487 0
NRSF pAbJurkat 67875724 67876205 481 0
NRSF pAbJurkat 67896002 67896702 700 0
NRSF pAbJurkat 67897485 67897609 124 0
NRSF pAbJurkat 67912808 67913477 669 0
NRSF pAbJurkat 67933911 67934216 305 0
NRSF pAbJurkat 67956833 67957165 332 0
NRSF pAbJurkat 67961888 67962479 591 0
NRSF pAbJurkat 67970159 67970549 390 0
Oct1 H2O2-HelaGSE14283 67931810 67931851 41 0
Oct1 HelaGSE14283 67840011 67840076 65 0
Oct1 HelaGSE14283 67846214 67846278 64 0
Oct1 HelaGSE14283 67849919 67849967 48 0
Oct1 HelaGSE14283 67893241 67893275 34 0
Oct1 HelaGSE14283 67899560 67899599 39 0
Oct1 HelaGSE14283 67906388 67906446 58 0
Oct1 HelaGSE14283 67921045 67921074 29 0
Oct1 HelaGSE14283 67931812 67931844 32 0
Oct1 HelaGSE14283 67950291 67950324 33 0
Oct4 ESGSE20650 67841450 67841825 375 0
P300 T0-glioblastomaGSE21026 67904159 67905154 995 0
P300 T30-glioblastomaGSE21026 67877814 67879310 1496 0
P300 T30-glioblastomaGSE21026 67903933 67905819 1886 0
RARA MCF7GSE15244 67860957 67861286 329 0
RARA MCF7GSE15244 67866685 67867699 1014 0
RARA MCF7GSE15244 67867999 67868322 323 0
RARA MCF7GSE15244 67873390 67874086 696 0
RARA MCF7GSE15244 67878234 67879250 1016 0
RARA MCF7GSE15244 67912261 67913799 1538 0
RARA MCF7GSE15244 67930814 67931188 374 0
RARA MCF7GSE15244 67936802 67938656 1854 0
RARG MCF7GSE15244 67838072 67838799 727 0
RARG MCF7GSE15244 67851714 67852051 337 0
RARG MCF7GSE15244 67865430 67866347 917 0
RARG MCF7GSE15244 67866685 67868322 1637 0
RARG MCF7GSE15244 67873390 67874086 696 0
RARG MCF7GSE15244 67876285 67879288 3003 0
RARG MCF7GSE15244 67904615 67904885 270 0
RARG MCF7GSE15244 67910235 67910809 574 0
RARG MCF7GSE15244 67930545 67931188 643 0
RARG MCF7GSE15244 67936802 67939168 2366 0
RARG MCF7GSE15244 67971840 67971970 130 0
Rb GrowingGSE19898 67904346 67904672 326 0
Rb QuiescentGSE19898 67904283 67904775 492 0
Rb SenescentGSE19898 67904385 67904833 448 0
TAF HelaGSE8489 67837750 67838426 676 0
TAF HelaGSE8489 67876249 67877097 848 0
TAF k562GSE8489 67837523 67838683 1160 0
TFAP2C MCF7GSE21234 67865101 67865832 731 0
TFAP2C MCF7GSE21234 67866130 67868514 2384 0
TFAP2C MCF7GSE21234 67894373 67894981 608 0
hScc1 BcellGSE12603 67836938 67837332 394 0
hScc1 BcellGSE12603 67861622 67861930 308 0
hScc1 BcellGSE12603 67887858 67888243 385 0
hScc1 BcellGSE12603 67907839 67908501 662 0
hScc1 BcellGSE12603 67919686 67920035 349 0
hScc1 BcellGSE12603 67928395 67928708 313 0
hScc1 BcellGSE12603 67930545 67930740 195 0
hScc1 BcellGSE12603 67935574 67935865 291 0
hScc1 BcellGSE12603 67937803 67938180 377 0
hScc1 BcellGSE12603 67947365 67947628 263 0
hScc1 BcellGSE12603 67961993 67962554 561 0
hScc1 BcellGSE12603 67971193 67971804 611 0
hScc1 CdLSGSE12603 67836938 67837819 881 0
hScc1 CdLSGSE12603 67887717 67888276 559 0
hScc1 CdLSGSE12603 67894738 67895749 1011 0
hScc1 CdLSGSE12603 67907839 67908501 662 0
hScc1 CdLSGSE12603 67941121 67941466 345 0
hScc1 CdLSGSE12603 67971193 67971970 777 0
hScc1 G2GSE9613 67971089 67971970 881 0
p130 QuiescentGSE19898 67878165 67878313 148 0
p130 QuiescentGSE19898 67878471 67878677 206 0
p130 QuiescentGSE19898 67904260 67904670 410 0
p130 SenescentGSE19898 67904251 67904833 582 0
p130 shRbQuiescentGSE19898 67904227 67904873 646 0
p63 keratinocytesGSE17611 67860993 67863047 2054 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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