AutismKB 2.0

Annotation Detail for LTK


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Basic Information Top
Gene Symbol:LTK ( TYK1 )
Gene Full Name: leukocyte receptor tyrosine kinase
Band: 15q15.1
Quick LinksEntrez ID:4058; OMIM: 151520; Uniprot ID:LTK_HUMAN; ENSEMBL ID: ENSG00000062524; HGNC ID: 6721
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
257N-linked (GlcNAc...) (Potential).
380N-linked (GlcNAc...) (Potential).
412N-linked (GlcNAc...) (Potential).
672Phosphotyrosine.
676Phosphotyrosine; by autocatalysis (By
677Phosphotyrosine.
Location(AA) Modifications Resource
257N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
380N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
412N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
676Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
21Phosphoserine(CDK)HMM predict
24Phosphoserine(ATM)HMM predict
32Phosphoserine(CDK)HMM predict
32Phosphoserine(MAPK)HMM predict
32Phosphoserine(CDC2)HMM predict
38Phosphoserine(CDC2)HMM predict
38Phosphoserine(CDK)HMM predict
38Phosphoserine(MAPK)HMM predict
38O-linkedHMM predict
51Phosphoserine(IKK)HMM predict
57Phosphoserine(MAPK)HMM predict
57Phosphoserine(CDC2)HMM predict
61Phosphoserine(MAPK)HMM predict
61Phosphoserine(CDC2)HMM predict
245MethylarginineHMM predict
248Phosphothreonine(PKC)HMM predict
251Phosphoserine(CDC2)HMM predict
251Phosphoserine(CDK)HMM predict
257N-linkedHMM predict
267MethylarginineHMM predict
283Phosphoserine(PKB)HMM predict
283Phosphoserine(CDC2)HMM predict
306Phosphothreonine(PKC)HMM predict
331Phosphotyrosine(INSR)HMM predict
332MethylarginineHMM predict
380N-linkedHMM predict
412N-linkedHMM predict
470Phosphoserine(CK1)HMM predict
509N-linkedHMM predict
545Phosphothreonine(PKC)HMM predict
721Phosphotyrosine(Jak)HMM predict
746MethylarginineHMM predict
769Phosphoserine(PKA)HMM predict
798Phosphothreonine(MAPK)HMM predict
824Phosphoserine(CDC2)HMM predict
834Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002344
  • Location:chr15 39583131-39593368
  • strand:-
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 39590803 39591224 421 0
H3ac HepG2E 39587180 39587742 562 0
RARA MCF7GSE15244 39587145 39587742 597 0
TFAP2C MCF7GSE21234 39587326 39587934 608 0
hScc1 BcellGSE12603 39586860 39587180 320 0
hScc1 BcellGSE12603 39590610 39591773 1163 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018