AutismKB 2.0

Annotation Detail for LYN


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LYN ( FLJ26625,JTK8 )
Gene Full Name: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Band: 8q12.1
Quick LinksEntrez ID:4067; OMIM: 165120; Uniprot ID:LYN_HUMAN; ENSEMBL ID: ENSG00000147507,ENSG00000249529,ENSG00000250967; HGNC ID: 6735
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
6Phosphoserine.
11Phosphoserine.
13Phosphoserine.
30Phosphothreonine.
32Phosphotyrosine.
37Phosphothreonine.
193Phosphotyrosine.
194Phosphotyrosine.
228Phosphoserine.
265Phosphotyrosine.
306Phosphotyrosine.
316Phosphotyrosine.
397Phosphotyrosine; by autocatalysis (By
473Phosphotyrosine.
489Phosphothreonine.
502Phosphothreonine.
508Phosphotyrosine.
Location(AA) Modifications Resource
2N-myristoyl glycine (By similarity).Swiss-Prot 53.0
3S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
11Phosphoserine.Swiss-Prot 53.0
13Phosphoserine.Swiss-Prot 53.0
192PhosphotyrosinePhospho.ELM 6.0
396Phosphotyrosine (Lyn)Phospho.ELM 6.0
397Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
507Phosphotyrosine (Csk)Phospho.ELM 6.0
508Phosphotyrosine.Swiss-Prot 53.0
Location(AA) Modification Resource
13Phosphoserine(CK1)HMM predict
38Phosphoserine(IKK)HMM predict
48Phosphoserine(IKK)HMM predict
194Phosphotyrosine(INSR)HMM predict
268N-linkedHMM predict
276Phosphothreonine(PKC)HMM predict
316Phosphotyrosine(Jak)HMM predict
316Phosphotyrosine(SRC)HMM predict
316SulfotyrosineHMM predict
316Phosphotyrosine(EGFR)HMM predict
363Phosphotyrosine(INSR)HMM predict
397PhosphotyrosineHMM predict
397Phosphotyrosine(Syk)HMM predict
397Phosphotyrosine(Jak)HMM predict
397Phosphotyrosine(INSR)HMM predict
460Phosphotyrosine(Syk)HMM predict
492Phosphotyrosine(Jak)HMM predict
501Phosphotyrosine(Jak)HMM predict
501Phosphotyrosine(Syk)HMM predict
508Phosphotyrosine(SRC)HMM predict
508PhosphotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002350
  • Location:chr8 56954925-57085684
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Pol2 GM12878GSE19551 56953825 56955313 1488 357
Stat6 IL-4-hr4GSE17850 56947367 56948027 660 7229
TFAP2C MCF7GSE21234 56943514 56943834 320 11252
TFAP2C MCF7GSE21234 56954533 56954971 438 174
hScc1 BcellGSE12603 56954212 56955351 1139 144
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 57085790 57085997 207 209
CTCF CD4GSE12889 57104035 57104325 290 18496
CTCF CD4SISSRdata 57085790 57085997 207 209
CTCF CD4SISSRdata 57104035 57104325 290 18496
CTCF JurkatGSE12889 57085737 57085989 252 179
CTCF G2GSE9613 57094446 57094974 528 9026
Myc K562GSE19551 57103967 57104260 293 18429
hScc1 BcellGSE12603 57104101 57104352 251 18542
hScc1 CdLSGSE12603 57104101 57104423 322 18578
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 56954722 56955960 1238 0
CTCF G2GSE9613 56988982 56989248 266 0
CTCF G2GSE9613 57020920 57021378 458 0
CTCF G2GSE9613 57033079 57033301 222 0
CTCF G2GSE9613 57047092 57047606 514 0
CTCF G2GSE9613 57051542 57051923 381 0
CTCF G2GSE9613 57053602 57053864 262 0
CTCF G2GSE9613 57054854 57055123 269 0
CTCF G2GSE9613 57085145 57086041 896 0
ER Breast-CancerGSE22609 57023551 57024125 574 0
ER MCF7GSE19013 56995257 56995735 478 0
ER MCF7GSE19013 57023565 57024328 763 0
FOXA1 DLD1GSE12801 57063857 57064744 887 0
FOXA1 MCF7GSE15244 57063857 57064744 887 0
FOXA1 MCF7GSE15244 57066041 57066362 321 0
FoxA1 MCF7MACSdata 57001255 57001548 293 0
FoxA1 MCF7MACSdata 57064067 57064377 310 0
GATA3 MCF7GSE15244 57066041 57066446 405 0
Gata2 K562GSE18868 57016041 57016759 718 0
Myc K562GSE19551 56988954 56989410 456 0
Myc K562GSE19551 57005640 57006135 495 0
NFkBII GM10847GSE19485 56953550 56957017 3467 0
NFkBII GM12878GSE19485 57047378 57049443 2065 0
NFkBII GM12878GSE19485 57062780 57070087 7307 0
NFkBII GM12892GSE19485 57063158 57065094 1936 0
NFkBII GM15510GSE19485 56953807 56957983 4176 0
NRSF pAbJurkat 57053747 57054127 380 0
Nanog ESGSE20650 57005600 57006184 584 0
Nanog ESGSE20650 57059939 57060452 513 0
Nanog hESGSE18292 57060052 57060321 269 0
Oct4 hESGSE17917 57005740 57006012 272 0
Oct4 hESGSE21916 57005600 57006138 538 0
P300 T0-glioblastomaGSE21026 56976496 56977391 895 0
P300 T30-glioblastomaGSE21026 56975444 56977608 2164 0
P300 T30-glioblastomaGSE21026 57023291 57024033 742 0
RARA MCF7GSE15244 57063571 57064744 1173 0
RARA MCF7GSE15244 57066041 57066296 255 0
RARG MCF7GSE15244 57063826 57064744 918 0
RARG MCF7GSE15244 57066041 57066791 750 0
STAT1 HeLaGSE12782 56981513 56982709 1196 0
STAT1 HeLaGSE12783 56981567 56982631 1064 0
STAT1 IFNSISSRdata 56981848 56982457 609 0
TFAP2C MCF7GSE21234 56961415 56962107 692 0
TFAP2C MCF7GSE21234 57063895 57064621 726 0
TFAP2C MCF7GSE21234 57072577 57072895 318 0
hScc1 BcellGSE12603 56956500 56957426 926 0
hScc1 BcellGSE12603 57005736 57005919 183 0
hScc1 BcellGSE12603 57047164 57047569 405 0
hScc1 CdLSGSE12603 56954722 56955924 1202 0
hScc1 CdLSGSE12603 56956531 56957221 690 0
hScc1 CdLSGSE12603 56960637 56961225 588 0
hScc1 CdLSGSE12603 57005425 57005919 494 0
hScc1 CdLSGSE12603 57014655 57015436 781 0
hScc1 CdLSGSE12603 57047059 57047535 476 0
p63 keratinocytesGSE17611 56981642 56982519 877 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-181a hsa-mir-181a-2 9 20693279
hsa-miR-181a hsa-mir-181a-1 1 20693279
hsa-miR-181a* hsa-mir-181a-1 1 20693279
hsa-miR-181a-2* hsa-mir-181a-2 9 20693279
hsa-miR-181b hsa-mir-181b-1 1 20693279
hsa-miR-181b hsa-mir-181b-2 9 20693279
hsa-miR-181c hsa-mir-181c 19 20693279
hsa-miR-181c* hsa-mir-181c 19 20693279
hsa-miR-181d hsa-mir-181d 19 20693279
hsa-miR-205 hsa-mir-205 1 21330408
hsa-miR-337-5p hsa-mir-337 14 19290526
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
25450 mRNA LYN chr8 56954925 57085685 641 EST chr8 56959554 56960195 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved