Annotation Detail for SMAD4

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Basic Information Top

Gene Symbol:	SMAD4 ( DPC4,JIP,MADH4 )
Gene Full Name:	SMAD family member 4
Band:	18q21.2
Quick Links	Entrez ID:4089; OMIM: 600993; Uniprot ID:SMAD4_HUMAN; ENSEMBL ID: ENSG00000141646; HGNC ID: 6770
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modifications	Resource
277	Phosphothreonine (MAP2K2)	Phospho.ELM 6.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3ac	HepG2	E	46809608	46810663	1055	475
Oct1	Hela	GSE14283	46791156	46791191	35	19437
PHF8	293T	GSE20725	46810016	46811113	1097	46
PHF8	Hs68minusFBS	GSE20725	46809552	46811397	1845	136
p130	Quiescent	GSE19898	46809824	46810452	628	473
p130	shRbQuiescent	GSE19898	46809974	46810823	849	212

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ER	E2-MCF7	GSE14664	46868883	46868924	41	8760
Oct1	H2O2-Hela	GSE14283	46872658	46872689	31	12530
Oct1	H2O2-Hela	GSE14283	46875122	46875159	37	14997
Oct1	Hela	GSE14283	46868870	46868922	52	8753
Oct1	Hela	GSE14283	46872655	46872692	37	12530
Oct1	Hela	GSE14283	46875122	46875162	40	14999

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	46831545	46831865	320
CTCF	CD4	SISSRdata	46831545	46831865	320
CTCF	G2	GSE9613	46810249	46811264	1015
CTCF	G2	GSE9613	46831407	46831870	463
ER	E2-MCF7	GSE14664	46831775	46831818	43
ER	E2-MCF7	GSE14664	46836911	46836947	36
H3K4me3	colorectal	cancer	46811412	46812369	957
Nanog	hES	GSE18292	46829063	46830371	1308
Oct1	H2O2-Hela	GSE14283	46848060	46848087	27
Oct1	H2O2-Hela	GSE14283	46852264	46852292	28
Oct1	Hela	GSE14283	46829172	46829230	58
Oct1	Hela	GSE14283	46831776	46831814	38
Oct1	Hela	GSE14283	46833892	46833922	30
Oct1	Hela	GSE14283	46836915	46836952	37
Oct1	Hela	GSE14283	46848060	46848088	28
PHF8	HeLa	GSE20725	46810026	46811446	1420
PHF8	Hs68plusFBS	GSE20725	46809829	46811402	1573
PolII	HeLa	GSE12783	46809825	46811615	1790
hScc1	Bcell	GSE12603	46810169	46811136	967
hScc1	CdLS	GSE12603	46831198	46832008	810

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-146a	hsa-mir-146a	5	20577838
hsa-miR-146a*	hsa-mir-146a	5	20577838
hsa-miR-155	hsa-mir-155	21	18794355
hsa-miR-155*	hsa-mir-155	21	18794355
hsa-miR-17	hsa-mir-17	13	20940405
hsa-miR-17*	hsa-mir-17	13	20940405
hsa-miR-181a	hsa-mir-181a-2	9	20023698
hsa-miR-181a	hsa-mir-181a-1	1	20023698
hsa-miR-181a*	hsa-mir-181a-1	1	20023698
hsa-miR-181a-2*	hsa-mir-181a-2	9	20023698
hsa-miR-181b	hsa-mir-181b-1	1	20023698
hsa-miR-181b	hsa-mir-181b-2	9	20023698
hsa-miR-181c	hsa-mir-181c	19	20023698
hsa-miR-181c*	hsa-mir-181c	19	20023698
hsa-miR-181d	hsa-mir-181d	19	20023698
hsa-miR-206	hsa-mir-206	6	19341710
hsa-miR-21	hsa-mir-21	17	18548003
hsa-miR-21*	hsa-mir-21	17	18548003
hsa-miR-224	hsa-mir-224	X	20118412
hsa-miR-23a	hsa-mir-23a	19	18508316
hsa-miR-23a*	hsa-mir-23a	19	18508316
hsa-miR-421	hsa-mir-421	X	21352803
hsa-miR-483-3p	hsa-mir-483	11	21112326
hsa-miR-92a	hsa-mir-92a-1	13	20940405
hsa-miR-92a	hsa-mir-92a-2	X	20940405

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018