Annotation Detail for SMAD5

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	SMAD5 ( DKFZp781C1895,DKFZp781O1323,Dwfc,JV5-1,MADH5 )
Gene Full Name:	SMAD family member 5
Band:	5q31.1
Quick Links	Entrez ID:4090; OMIM: 603110; Uniprot ID:SMAD5_HUMAN; ENSEMBL ID: ENSG00000113658; HGNC ID: 6771
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	MCF7	GSE15244	135486499	135487668	1169	9351
FoxA1	MCF7	MACSdata	135486766	135487235	469	9434
Oct1	H2O2-Hela	GSE14283	135486750	135486803	53	9658
Oct1	Hela	GSE14283	135486742	135486801	59	9663
P300	T30-glioblastoma	GSE21026	135486752	135487525	773	9296

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	135555308	135556088	780	9378
CTCF	G2	GSE9613	135556435	135557443	1008	10619
ER	Fulvestrant-MCF7	GSE14664	135548182	135548227	45	1884
Gata2	K562	GSE18868	135552378	135552943	565	6340

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	135537765	135537939	174
CTCF	CD4	SISSRdata	135537765	135537939	174
ER	E2-MCF7	GSE14664	135542584	135542618	34
ER	E2-MCF7	GSE14664	135544468	135544500	32
ER	Fulvestrant-MCF7	GSE14664	135542584	135542618	34
FoxA1	MCF7	MACSdata	135513407	135513686	279
Myc	hES	GSE17917	135496266	135496657	391
Myc	hES	GSE17917	135537966	135538264	298
Nanog	hES	GSE18292	135537640	135538150	510
Oct1	H2O2-Hela	GSE14283	135542586	135542617	31
Oct1	Hela	GSE14283	135503127	135503156	29
Oct1	Hela	GSE14283	135505279	135505319	40
Oct1	Hela	GSE14283	135542587	135542615	28
PHF8	HeLa	GSE20725	135495998	135497462	1464
PHF8	Hs68minusFBS	GSE20725	135495808	135497770	1962
PHF8	Hs68plusFBS	GSE20725	135495855	135497536	1681
Rb	Quiescent	GSE19898	135497336	135497604	268
hScc1	CdLS	GSE12603	135537577	135538092	515
p130	Quiescent	GSE19898	135497250	135497449	199
p130	shRbSenescent	GSE19898	135497188	135497571	383
p63	keratinocytes	GSE17611	135500959	135502006	1047

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-133a	hsa-mir-133a-1	18	18784367
hsa-miR-133a	hsa-mir-133a-2	20	18784367
hsa-miR-133b	hsa-mir-133b	6	18784367
hsa-miR-135a	hsa-mir-135a-1	3	18784367
hsa-miR-135a	hsa-mir-135a-2	12	18784367
hsa-miR-135a*	hsa-mir-135a-1	3	18784367
hsa-miR-135b	hsa-mir-135b	1	18784367
hsa-miR-135b*	hsa-mir-135b	1	18784367
hsa-miR-155	hsa-mir-155	21	20427544
hsa-miR-155	hsa-mir-155	21	20133617
hsa-miR-155	hsa-mir-155	21	18367535
hsa-miR-155*	hsa-mir-155	21	20427544
hsa-miR-155*	hsa-mir-155	21	20133617
hsa-miR-155*	hsa-mir-155	21	18367535
hsa-miR-34c-3p	hsa-mir-34c	11	18784367
hsa-miR-34c-5p	hsa-mir-34c	11	18784367
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
286	Unknown	MicroArray	miR-124	SMAD5	n_a	15685193
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000113658		G1-to-S transition	n_a	n_a	"epithelium, squamous cell, lymphoblast, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
21504	mRNA	SMAD5	chr5	135496940	135517351	607	mRNA	DAMS	chr5	135493102	135498478	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018