AutismKB 2.0

Annotation Detail for MAN2A2


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Basic Information Top
Gene Symbol:MAN2A2 ( MANA2X )
Gene Full Name: mannosidase, alpha, class 2A, member 2
Band: 15q25
Quick LinksEntrez ID:4122; OMIM: 600988; Uniprot ID:MA2A2_HUMAN; ENSEMBL ID: ENSG00000196547; HGNC ID: 6825
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
95N-linked (GlcNAc...) (Potential).
305N-linked (GlcNAc...) (Potential).
1082N-linked (GlcNAc...) (Potential).
1120N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
95N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
305N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1082N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1120N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
95N-linkedHMM predict
187SulfotyrosineHMM predict
305N-linkedHMM predict
354SulfotyrosineHMM predict
429Phosphotyrosine(Jak)HMM predict
429Phosphotyrosine(Syk)HMM predict
442Phosphotyrosine(EGFR)HMM predict
670Phosphoserine(CDC2)HMM predict
677Phosphoserine(CK1)HMM predict
729Phosphothreonine(CDK)HMM predict
732Phosphoserine(CDC2)HMM predict
744Phosphoserine(CAMK2)HMM predict
807Phosphoserine(PKA)HMM predict
823Phosphoserine(CDC2)HMM predict
825Phosphothreonine(PKC)HMM predict
826Phosphoserine(CDC2)HMM predict
826O-linkedHMM predict
826Phosphoserine(IKK)HMM predict
826Phosphoserine(CDK)HMM predict
826Phosphoserine(MAPK)HMM predict
841Phosphoserine(ATM)HMM predict
866S-palmitoylHMM predict
883O-linkedHMM predict
893O-linkedHMM predict
991Phosphoserine(IKK)HMM predict
1082N-linkedHMM predict
1117Phosphoserine(CDC2)HMM predict
1117Phosphoserine(CDK)HMM predict
1120N-linkedHMM predict
1125Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006122
  • Location:chr15 89248423-89266817
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 89246420 89246791 371 1818
CTCF CD4SISSRdata 89246420 89246791 371 1818
CTCF G2GSE9613 89246529 89247731 1202 1294
Gata1 K562GSE18868 89245846 89246539 693 2231
Gata2 K562GSE18868 89245719 89246823 1104 2153
H3K4me3 colorectalcancer 89246778 89247118 340 1476
P300 T0-glioblastomaGSE21026 89246283 89247084 801 1740
PHF8 293TGSE20725 89246397 89247722 1325 1364
PHF8 HeLaGSE20725 89246420 89247836 1416 1296
PHF8 Hs68minusFBSGSE20725 89246393 89247244 851 1605
TFAP2C MCF7GSE21234 89246363 89246821 458 1832
hScc1 BcellGSE12603 89246529 89247188 659 1565
hScc1 CdLSGSE12603 89246529 89246821 292 1749
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 89268191 89268554 363 1555
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 89254579 89255394 815 0
CTCF G2GSE9613 89259612 89260005 393 0
CTCF G2GSE9613 89261229 89262056 827 0
hScc1 BcellGSE12603 89249458 89249801 343 0
hScc1 BcellGSE12603 89250866 89251136 270 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018