Annotation Detail for MAN2A1

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Basic Information Top

Gene Symbol:	MAN2A1 ( GOLIM7,MANA2,MANII )
Gene Full Name:	mannosidase, alpha, class 2A, member 1
Band:	5q21.3
Quick Links	Entrez ID:4124; OMIM: 154582; Uniprot ID:MA2A1_HUMAN; ENSEMBL ID: ENSG00000112893; HGNC ID: 6824
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
78	N-linked (GlcNAc...).
80	Phosphoserine (By similarity).
82	Phosphoserine (By similarity).
93	N-linked (GlcNAc...) (Potential).
1125	N-linked (GlcNAc...).

Location(AA)	Modifications	Resource
78	N-linked (GlcNAc...).	Swiss-Prot 53.0
80	Phosphoserine (By similarity).	Swiss-Prot 53.0
82	Phosphoserine (By similarity).	Swiss-Prot 53.0
93	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
1125	N-linked (GlcNAc...).	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	109052508	109053303	795	149
FoxA1	MCF7	MACSdata	109052095	109052228	133	893
p63	keratinocytes	GSE17611	109045216	109046351	1135	7271

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Rb	Senescent	GSE19898	109240981	109241163	182	9745
hScc1	Bcell	GSE12603	109248801	109249095	294	17621

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	109053667	109054091	424
CTCF	G2	GSE9613	109054369	109055086	717
ER	MCF7	GSE19013	109078173	109078602	429
FoxA1	MCF7	MACSdata	109071161	109071364	203
FoxA1	MCF7	MACSdata	109078614	109078811	197
Gata2	K562	GSE18868	109067259	109067885	626
H3K4me2	HCT116	GSE10453	109054663	109055050	387
H3K4me3	colorectal	cancer	109054467	109055248	781
H3ac	HepG2	E	109054540	109055212	672
Myc	K562	GSE19551	109107392	109107800	408
Myc	K562	GSE19551	109169573	109169923	350
Nanog	hES	GSE18292	109104533	109106072	1539
Nanog	hES	GSE18292	109201570	109202214	644
Oct1	Hela	GSE14283	109063543	109063580	37
PHF8	HeLa	GSE20725	109052385	109054299	1914
Sox2	hES	GSE18292	109105109	109105519	410
TFAP2C	MCF7	GSE21234	109057963	109058316	353
hScc1	Bcell	GSE12603	109052508	109053731	1223
hScc1	Bcell	GSE12603	109054283	109055113	830
hScc1	CdLS	GSE12603	109052508	109053848	1340
hScc1	CdLS	GSE12603	109054369	109055190	821
hScc1	G2	GSE9613	109053667	109055050	1383

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
329	Unknown	MicroArray	miR-124	MAN2A1	n_a	15685193
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000112893		G1-to-S transition	n_a	n_a	"epithelium, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018