AutismKB 2.0

Annotation Detail for MANBA


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Basic Information Top
Gene Symbol:MANBA ( MANB1 )
Gene Full Name: mannosidase, beta A, lysosomal
Band: 4q24
Quick LinksEntrez ID:4126; OMIM: 609489; Uniprot ID:MANBA_HUMAN; ENSEMBL ID: ENSG00000109323; HGNC ID: 6831
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
28N-linked (GlcNAc...) (Potential).
35N-linked (GlcNAc...) (Potential).
77N-linked (GlcNAc...) (Potential).
280N-linked (GlcNAc...) (Potential).
284N-linked (GlcNAc...) (Potential).
297N-linked (GlcNAc...) (Potential).
302N-linked (GlcNAc...) (Potential).
763N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
28N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
35N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
77N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
280N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
284N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
297N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
302N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
763N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
28N-linkedHMM predict
33N-linkedHMM predict
35N-linkedHMM predict
77N-linkedHMM predict
161Phosphotyrosine(Syk)HMM predict
284N-linkedHMM predict
297N-linkedHMM predict
301Phosphotyrosine(Abl)HMM predict
302N-linkedHMM predict
336Phosphoserine(CDC2)HMM predict
477Phosphotyrosine(INSR)HMM predict
504O-linkedHMM predict
506Phosphoserine(CDC2)HMM predict
570Phosphoserine(CK2)HMM predict
571Phosphoserine(CK1)HMM predict
572Phosphothreonine(PKC)HMM predict
582Phosphoserine(CK1)HMM predict
736Phosphothreonine(PKA)HMM predict
761S-palmitoylHMM predict
763N-linkedHMM predict
768Phosphoserine(PKA)HMM predict
809Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005908
  • Location:chr4 103771690-103901195
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 103901312 103901633 321 277
FOXA1 eGFPGSE10845 103901312 103901633 321 277
Oct1 HelaGSE14283 103902688 103902736 48 1517
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 103765782 103766152 370 5724
CTCF CD4SISSRdata 103765782 103766152 370 5724
hScc1 BcellGSE12603 103765758 103766292 534 5666
hScc1 CdLSGSE12603 103765758 103766292 534 5666
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 103774776 103775015 239 0
CTCF G2GSE9613 103776255 103776426 171 0
CTCF G2GSE9613 103858190 103858441 251 0
CTCF G2GSE9613 103868964 103869572 608 0
CTCF G2GSE9613 103874487 103875517 1030 0
CTCF G2GSE9613 103900633 103901264 631 0
FoxA1 MCF7MACSdata 103898489 103898721 232 0
H3K4me2 HCT116GSE10453 103899643 103900772 1129 0
H3K4me3 colorectalcancer 103899643 103901219 1576 0
H3ac HepG2E 103900141 103900772 631 0
Myc hESGSE17917 103900836 103901261 425 0
P300 T30-glioblastomaGSE21026 103874724 103875286 562 0
RNAII Tamoxifen-MCF7GSE14664 103823805 103823893 88 0
TAF HelaGSE8489 103899710 103900854 1144 0
TFAP2C MCF7GSE21234 103818341 103818630 289 0
TFAP2C MCF7GSE21234 103872532 103872995 463 0
TFAP2C MCF7GSE21234 103877273 103877733 460 0
hScc1 BcellGSE12603 103868890 103869381 491 0
hScc1 BcellGSE12603 103900410 103901312 902 0
hScc1 G2GSE9613 103900339 103901633 1294 0
p130 shRbQuiescentGSE19898 103836618 103837253 635 0
p63 keratinocytesGSE17611 103824497 103825492 995 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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