AutismKB 2.0

Annotation Detail for MAPT


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Basic Information Top
Gene Symbol:MAPT ( DDPAC,FLJ31424,FTDP-17,MAPTL,MGC138549,MSTD,MTBT1,MTBT2,PPND,TAU )
Gene Full Name: microtubule-associated protein tau
Band: 17q21.31
Quick LinksEntrez ID:4137; OMIM: 157140; Uniprot ID:TAU_HUMAN; ENSEMBL ID: ENSG00000186868; HGNC ID: 6893
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
46Phosphoserine; by PDPK.
50Phosphothreonine; by PDPK.
87N-linked (Glc) (glycation); in PHF-tau;
111Phosphothreonine (By similarity).
383N-linked (Glc) (glycation); in PHF-tau;
467N-linked (Glc) (glycation); in PHF-tau;
470Phosphothreonine; by PDPK.
480N-linked (Glc) (glycation); in PHF-tau;
484Deamidated asparagine; in tau and PHF-
491N-linked (Glc) (glycation); in PHF-tau;
492Phosphothreonine; by PDPK.
498Phosphothreonine; by PDPK.
514Phosphotyrosine; by TTBK1.
515Phosphoserine; by PDPK and TTBK1.
516Phosphoserine; by PDPK and TTBK1.
519Phosphoserine; by PDPK and TTBK1.
522Phosphothreonine; by PDPK.
529Phosphothreonine; by PDPK.
531Phosphoserine; by PKA.
534Phosphothreonine; by PDPK.
542N-linked (Glc) (glycation); in PHF-tau;
548Phosphothreonine; by PDPK.
551N-linked (Glc) (glycation); in PHF-tau;
552Phosphoserine; by PDPK.
554Phosphoserine; in PHF-tau.
576N-linked (Glc) (glycation); in PHF-tau;
579Phosphoserine; by MARK1.
596Deamidated asparagine; in tau and PHF-
597N-linked (Glc) (glycation); in PHF-tau;
598N-linked (Glc) (glycation); in PHF-tau;
610Phosphoserine; by MARK1; in PHF-tau.
622Phosphoserine; by MARK1; in PHF-tau.
641Phosphoserine; by MARK1; in PHF-tau.
664N-linked (Glc) (glycation); in PHF-tau;
670N-linked (Glc) (glycation); in PHF-tau;
673Phosphoserine; by MARK1; in PHF-tau.
686N-linked (Glc) (glycation); in PHF-tau;
713Phosphoserine; by PDPK.
717Phosphoserine.
720Phosphothreonine.
721Phosphoserine; by PDPK.
726Phosphoserine.
729Phosphoserine (By similarity).
731Phosphothreonine (By similarity).
733Phosphoserine; by CaMK2 and TTBK1.
739Phosphoserine; by PDPK and TTBK1.
744Phosphothreonine; by TTBK1.
Location(AA) Modifications Resource
2N-acetylalanine.Swiss-Prot 53.0
46Phosphoserine; by PDPK.Swiss-Prot 53.0
50Phosphothreonine; by PDPK.Swiss-Prot 53.0
87N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
111Phosphothreonine (By similarity).Swiss-Prot 53.0
236Phosphoserine (PHK
261Phosphoserine (PHK
284Phosphoserine (PHK
304Phosphoserine (PHK
351Phosphoserine (PHK
383N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
467N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
470Phosphothreonine; by PDPK.Swiss-Prot 53.0
480N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
484Deamidated asparagine; in tau and PHF-tau; partial.Swiss-Prot 53.0
491N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
492Phosphothreonine; by PDPK.Swiss-Prot 53.0
498Phosphothreonine; by PDPK.Swiss-Prot 53.0
514Phosphotyrosine (By similarity).Swiss-Prot 53.0
515Phosphoserine; by PDPK.Swiss-Prot 53.0
516Phosphoserine; by PDPK.Swiss-Prot 53.0
518Phosphoserine (CDK
519Phosphoserine; by PDPK.Swiss-Prot 53.0
521Phosphothreonine (CDK
522Phosphothreonine; by PDPK.Swiss-Prot 53.0
528Phosphothreonine (CDK
529Phosphothreonine; by PDPK.Swiss-Prot 53.0
530Phosphoserine (PKA
531Phosphoserine; by PKA.Swiss-Prot 53.0
533Phosphothreonine (CDK
534Phosphothreonine; by PDPK.Swiss-Prot 53.0
542N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
547Phosphothreonine (CDK
548Phosphothreonine; by PDPK.Swiss-Prot 53.0
551N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
551Phosphoserine (CDK
552Phosphoserine; by PDPK.Swiss-Prot 53.0
554Phosphoserine; in PHF-tau.Swiss-Prot 53.0
571Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin) (inPHF-tau).Swiss-Prot 53.0
574Phosphoserine (GSK-3beta)Phospho.ELM 6.0
576N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
578Phosphoserine (GSK-3beta)Phospho.ELM 6.0
579Phosphoserine; by MARK1.Swiss-Prot 53.0
596Deamidated asparagine; in tau and PHF-tau; partial.Swiss-Prot 53.0
597N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
598N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
610Phosphoserine; by MARK1; in PHF-tau.Swiss-Prot 53.0
622Phosphoserine; by MARK1; in PHF-tau.Swiss-Prot 53.0
628Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin) (inPHF-tau).Swiss-Prot 53.0
641Phosphoserine; by MARK1; in PHF-tau.Swiss-Prot 53.0
664N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
670Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin) (inPHF-tau).Swiss-Prot 53.0
670N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
673Phosphoserine; by MARK1; in PHF-tau.Swiss-Prot 53.0
686N-linked (Glc) (glycation); in PHF-tau.Swiss-Prot 53.0
689Phosphothreonine (CDK
712Phosphoserine (CDK
713Phosphoserine; by PDPK.Swiss-Prot 53.0
717Phosphoserine (By similarity).Swiss-Prot 53.0
720Phosphoserine (CDK
720Phosphothreonine.Swiss-Prot 53.0
721Phosphoserine; by PDPK.Swiss-Prot 53.0
726Phosphoserine (By similarity).Swiss-Prot 53.0
729Phosphoserine (By similarity).Swiss-Prot 53.0
731Phosphothreonine (By similarity).Swiss-Prot 53.0
733Phosphoserine; by CaMK2.Swiss-Prot 53.0
739Phosphoserine; by PDPK.Swiss-Prot 53.0
Location(AA) Modification Resource
39Phosphothreonine(CK2)HMM predict
50PhosphothreonineHMM predict
50Phosphothreonine(MAPK)HMM predict
61Phosphoserine(CK2)HMM predict
61Phosphoserine(IKK)HMM predict
69Phosphothreonine(MAPK)HMM predict
113PhosphoserineHMM predict
171Phosphoserine(IKK)HMM predict
214Phosphoserine(IKK)HMM predict
235Phosphoserine(CDK)HMM predict
235O-linkedHMM predict
238Phosphoserine(IKK)HMM predict
282O-linkedHMM predict
318Phosphoserine(CK1)HMM predict
380Phosphoserine(CAMK2)HMM predict
382Phosphoserine(IKK)HMM predict
395Phosphothreonine(PKC)HMM predict
403Phosphothreonine(PKC)HMM predict
411Phosphoserine(CDC2)HMM predict
416Phosphothreonine(MAPK)HMM predict
416Phosphothreonine(CDK)HMM predict
428Phosphoserine(CDK)HMM predict
438Phosphoserine(CDK)HMM predict
438Phosphoserine(CDC2)HMM predict
438O-linkedHMM predict
446O-linkedHMM predict
447Phosphoserine(CK1)HMM predict
480O-linkedHMM predict
484N-linkedHMM predict
492Phosphothreonine(CDC2)HMM predict
498Phosphothreonine(CDC2)HMM predict
498Phosphothreonine(MAPK)HMM predict
498PhosphothreonineHMM predict
498Phosphothreonine(CDK)HMM predict
501O-linkedHMM predict
502Phosphoserine(ATM)HMM predict
502O-linkedHMM predict
514Phosphotyrosine(Syk)HMM predict
514Phosphotyrosine(INSR)HMM predict
515O-linkedHMM predict
516Phosphoserine(CDC2)HMM predict
516O-linkedHMM predict
516PhosphoserineHMM predict
516Phosphoserine(ATM)HMM predict
516Phosphoserine(CDK)HMM predict
519Phosphoserine(IKK)HMM predict
519Phosphoserine(CDC2)HMM predict
519Phosphoserine(ATM)HMM predict
519O-linkedHMM predict
519Phosphoserine(CDK)HMM predict
522O-linkedHMM predict
522Phosphothreonine(MAPK)HMM predict
522Phosphothreonine(CDC2)HMM predict
522Phosphothreonine(CDK)HMM predict
527O-linkedHMM predict
529Phosphothreonine(PKA)HMM predict
529Phosphothreonine(CDK)HMM predict
531Phosphoserine(PKA)HMM predict
531O-linkedHMM predict
531O-linkedHMM predict
531Phosphoserine(IKK)HMM predict
534Phosphothreonine(MAPK)HMM predict
534Phosphothreonine(CDK)HMM predict
548Phosphothreonine(CDK)HMM predict
548Phosphothreonine(MAPK)HMM predict
552Phosphoserine(CDK)HMM predict
552Phosphoserine(CDC2)HMM predict
554Phosphoserine(CDC2)HMM predict
641Phosphoserine(PKA)HMM predict
673Phosphoserine(PKA)HMM predict
676N-linkedHMM predict
713Phosphoserine(CDK)HMM predict
717O-linkedHMM predict
721Phosphoserine(CDK)HMM predict
721PhosphoserineHMM predict
726O-linkedHMM predict
726Phosphoserine(IKK)HMM predict
726Phosphoserine(PKA)HMM predict
727N-linkedHMM predict
733Phosphoserine(PKA)HMM predict
739PhosphoserineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005910
  • Location:chr17 41327623-41461543
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 41327480 41327690 210 39
CTCF CD4SISSRdata 41327480 41327690 210 39
CTCF HelaGSE12889 41327483 41327735 252 15
CTCF G2GSE9613 41327229 41327949 720 35
H3K27me3 colorectalcancer 41324950 41325556 606 2371
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 41435776 41436011 235 0
CTCF CD4SISSRdata 41435776 41436011 235 0
CTCF JurkatGSE12889 41435849 41436061 212 0
CTCF G2GSE9613 41382346 41382675 329 0
CTCF G2GSE9613 41388765 41388930 165 0
CTCF G2GSE9613 41404870 41405123 253 0
CTCF G2GSE9613 41433603 41433870 267 0
CTCF G2GSE9613 41435092 41435959 867 0
ER MCF7GSE19013 41332138 41333218 1080 0
ER MCF7GSE19013 41334075 41334794 719 0
Gata2 K562GSE18868 41335857 41336656 799 0
H3K27me3 colorectalcancer 41331489 41332208 719 0
H3ac HepG2E 41367559 41369529 1970 0
NRSF-mono JurkatQuESTdata 41389427 41389668 241 0
Oct1 H2O2-HelaGSE14283 41361868 41361911 43 0
Oct1 HelaGSE14283 41361868 41361907 39 0
Oct1 HelaGSE14283 41369605 41369680 75 0
Oct4 hESGSE21916 41375399 41376236 837 0
P300 T30-glioblastomaGSE21026 41442944 41443768 824 0
Rb shRbSenescenceGSE19898 41373643 41373827 184 0
STAT1 IFNSISSRdata 41410000 41410743 743 0
TFAP2C MCF7GSE21234 41334071 41334563 492 0
TFAP2C MCF7GSE21234 41386102 41386642 540 0
TFAP2C MCF7GSE21234 41407118 41407575 457 0
TFAP2C MCF7GSE21234 41454121 41454640 519 0
hScc1 BcellGSE12603 41327428 41328067 639 0
hScc1 BcellGSE12603 41378001 41378335 334 0
hScc1 BcellGSE12603 41429493 41429860 367 0
hScc1 BcellGSE12603 41435571 41435959 388 0
hScc1 BcellGSE12603 41445398 41446140 742 0
hScc1 CdLSGSE12603 41327465 41327980 515 0
hScc1 CdLSGSE12603 41435639 41435959 320 0
hScc1 G2GSE9613 41435352 41435959 607 0
p130 shRbSenescentGSE19898 41383379 41383533 154 0
p63 keratinocytesGSE17611 41392458 41392951 493 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
11268 mRNA MAPT chr17 41327623 41458611 75 mRNA chr17 41277025 41327933Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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