AutismKB 2.0

Annotation Detail for MARK1


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Basic Information Top
Gene Symbol:MARK1 ( KIAA1477,MARK,MGC126512,MGC126513 )
Gene Full Name: MAP/microtubule affinity-regulating kinase 1
Band: 1q41
Quick LinksEntrez ID:4139; OMIM: 606511; Uniprot ID:MARK1_HUMAN; ENSEMBL ID: ENSG00000116141; HGNC ID: 6896
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
5Phosphothreonine.
46Phosphoserine.
215Phosphothreonine.
219Phosphoserine.
394Phosphoserine (By similarity).
403Phosphoserine.
423Phosphoserine.
463Phosphoserine.
468Phosphoserine.
470Phosphoserine.
475Phosphoserine.
588Phosphoserine.
596Phosphothreonine.
633Phosphoserine.
649Phosphoserine.
666Phosphoserine (By similarity).
Location(AA) Modifications Resource
215Phosphothreonine.Swiss-Prot 53.0
215Phosphothreonine (LKB1)Phospho.ELM 6.0
219Phosphoserine (By similarity).Swiss-Prot 53.0
394Phosphoserine (By similarity).Swiss-Prot 53.0
403Phosphoserine (By similarity).Swiss-Prot 53.0
649Phosphoserine.Swiss-Prot 53.0
666Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
5Phosphothreonine(MAPK)HMM predict
17N-linkedHMM predict
24Phosphotyrosine(INSR)HMM predict
32O-linkedHMM predict
34Phosphoserine(CK1)HMM predict
34Phosphoserine(CDC2)HMM predict
46Phosphoserine(PKG)HMM predict
97N-linkedHMM predict
133Phosphotyrosine(INSR)HMM predict
177Phosphotyrosine(Jak)HMM predict
215PhosphothreonineHMM predict
222Phosphotyrosine(Abl)HMM predict
222Phosphotyrosine(Syk)HMM predict
233Phosphotyrosine(INSR)HMM predict
323Phosphotyrosine(INSR)HMM predict
331N-linkedHMM predict
397N-linkedHMM predict
398N-linkedHMM predict
403Phosphoserine(CDK)HMM predict
412Phosphoserine(IKK)HMM predict
423Phosphoserine(PKA)HMM predict
423Phosphoserine(PKB)HMM predict
423Phosphoserine(CK1)HMM predict
429O-linkedHMM predict
444Phosphoserine(CK2)HMM predict
447PhosphoserineHMM predict
468O-linkedHMM predict
485Phosphoserine(PKG)HMM predict
485Phosphoserine(IKK)HMM predict
504Phosphothreonine(PKC)HMM predict
504Phosphothreonine(PKA)HMM predict
505Phosphotyrosine(PKA)HMM predict
505Phosphotyrosine(Jak)HMM predict
514Phosphotyrosine(Jak)HMM predict
524Phosphoserine(IKK)HMM predict
531O-linkedHMM predict
542O-linkedHMM predict
554Phosphoserine(IKK)HMM predict
556Phosphoserine(CK1)HMM predict
558Phosphoserine(ATM)HMM predict
588O-linkedHMM predict
588Phosphoserine(MAPK)HMM predict
593Phosphoserine(CK1)HMM predict
593O-linkedHMM predict
595O-linkedHMM predict
595O-linkedHMM predict
596O-linkedHMM predict
598Phosphothreonine(CDC2)HMM predict
598Phosphothreonine(MAPK)HMM predict
609Phosphoserine(PKB)HMM predict
633Phosphoserine(CDC2)HMM predict
633Phosphoserine(CDK)HMM predict
633Phosphoserine(MAPK)HMM predict
633Phosphoserine(ATM)HMM predict
633PhosphoserineHMM predict
633Phosphoserine(MAPK)HMM predict
648Phosphothreonine(PKA)HMM predict
671O-linkedHMM predict
681Phosphoserine(CK2)HMM predict
732SulfotyrosineHMM predict
789IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_018650
  • Location:chr1 218768190-218903894
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TFAP2C MCF7GSE21234 218751176 218751516 340 16845
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 218768122 218768875 753 0
CTCF G2GSE9613 218785024 218785369 345 0
FoxA1 MCF7MACSdata 218844926 218845220 294 0
Rb shRbQuiescentGSE19898 218791072 218791234 162 0
hScc1 BcellGSE12603 218767964 218768912 948 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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