AutismKB 2.0

Annotation Detail for MCC


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Basic Information Top
Gene Symbol:MCC ( DKFZp762O1615,FLJ38893,FLJ46755,MCC1 )
Gene Full Name: mutated in colorectal cancers
Band: 5q22.2
Quick LinksEntrez ID:4163; OMIM: 159350; Uniprot ID:CRCM_HUMAN; ENSEMBL ID: ENSG00000171444; HGNC ID: 6935
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
294Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
11N-linkedHMM predict
18Phosphoserine(CK1)HMM predict
110SulfotyrosineHMM predict
110Phosphotyrosine(INSR)HMM predict
110Phosphotyrosine(SRC)HMM predict
110Phosphotyrosine(Syk)HMM predict
110Phosphotyrosine(EGFR)HMM predict
111Phosphoserine(SRC)HMM predict
111Phosphoserine(CK1)HMM predict
115Phosphoserine(CK1)HMM predict
118Phosphoserine(ATM)HMM predict
118Phosphoserine(CK1)HMM predict
120Phosphoserine(ATM)HMM predict
130Phosphoserine(IKK)HMM predict
143N-linkedHMM predict
154N-linkedHMM predict
159N-linkedHMM predict
179Phosphoserine(IKK)HMM predict
180Phosphoserine(IKK)HMM predict
257N-linkedHMM predict
262Phosphothreonine(PKA)HMM predict
286Phosphoserine(CAMK2)HMM predict
294Phosphoserine(CDC2)HMM predict
294Phosphoserine(CDK)HMM predict
315Phosphoserine(CK1)HMM predict
315Phosphoserine(IKK)HMM predict
315O-linkedHMM predict
333Phosphoserine(PKG)HMM predict
337Phosphoserine(IKK)HMM predict
339Phosphoserine(CK2)HMM predict
341Phosphoserine(CDC2)HMM predict
341Phosphoserine(CK1)HMM predict
359Phosphoserine(ATM)HMM predict
441N-linkedHMM predict
490Phosphoserine(IKK)HMM predict
494N-linkedHMM predict
543Phosphoserine(CK1)HMM predict
547O-linkedHMM predict
548O-linkedHMM predict
548O-linkedHMM predict
550O-linkedHMM predict
553O-linkedHMM predict
555Phosphoserine(IKK)HMM predict
556O-linkedHMM predict
660Phosphotyrosine(Jak)HMM predict
683Phosphoserine(CK1)HMM predict
683Phosphoserine(CK2)HMM predict
683Phosphoserine(IKK)HMM predict
702Phosphoserine(IKK)HMM predict
702Phosphoserine(MAPK)HMM predict
770Phosphoserine(PKG)HMM predict
770Phosphoserine(PKA)HMM predict
812IsoleucineHMM predict
820Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002387
  • Location:chr5 112389427-112658200
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 112662689 112663111 422 4700
CTCF G2GSE9613 112658187 112658554 367 170
H3K4me2 HCT116GSE10453 112658621 112659220 599 720
H3K4me3 colorectalcancer 112658726 112659291 565 808
P300 T30-glioblastomaGSE21026 112662784 112663346 562 4865
RARA MCF7GSE15244 112676294 112676617 323 18255
TAF HelaGSE8489 112661377 112662521 1144 3749
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 112399101 112399654 553 0
CTCF CD4GSE12889 112407242 112407393 151 0
CTCF CD4SISSRdata 112407242 112407393 151 0
CTCF JurkatGSE12889 112407274 112407528 254 0
CTCF G2GSE9613 112407152 112407409 257 0
CTCF G2GSE9613 112416958 112417310 352 0
CTCF G2GSE9613 112418205 112418667 462 0
CTCF G2GSE9613 112420701 112420862 161 0
CTCF G2GSE9613 112422390 112422587 197 0
CTCF G2GSE9613 112430641 112430926 285 0
CTCF G2GSE9613 112431661 112431942 281 0
CTCF G2GSE9613 112459715 112460135 420 0
CTCF G2GSE9613 112482917 112483232 315 0
ER E2-MCF7GSE14664 112548271 112548360 89 0
ER E2-MCF7GSE14664 112558432 112558464 32 0
ER E2-MCF7GSE14664 112564663 112564697 34 0
ER Fulvestrant-MCF7GSE14664 112527184 112527225 41 0
FOXA1 MCF7GSE15244 112566554 112567395 841 0
H3K27me3 colorectalcancer 112655874 112657934 2060 0
H3K4me3 colorectalcancer 112657158 112657865 707 0
Myc hESGSE17917 112597972 112598210 238 0
Nanog ESGSE20650 112444520 112445253 733 0
Nanog hESGSE18292 112444565 112445200 635 0
Nanog hESGSE18292 112563220 112563407 187 0
Nanog hESGSE18292 112608955 112609603 648 0
Oct1 H2O2-HelaGSE14283 112452848 112452888 40 0
Oct1 H2O2-HelaGSE14283 112483868 112483898 30 0
Oct1 H2O2-HelaGSE14283 112484627 112484654 27 0
Oct1 H2O2-HelaGSE14283 112564663 112564694 31 0
Oct1 H2O2-HelaGSE14283 112627922 112627948 26 0
Oct1 H2O2-HelaGSE14283 112655158 112655188 30 0
Oct1 HelaGSE14283 112398615 112398660 45 0
Oct1 HelaGSE14283 112452848 112452888 40 0
Oct1 HelaGSE14283 112480753 112480786 33 0
Oct1 HelaGSE14283 112483869 112483898 29 0
Oct1 HelaGSE14283 112502379 112502483 104 0
Oct1 HelaGSE14283 112502497 112502544 47 0
Oct1 HelaGSE14283 112509425 112509457 32 0
Oct1 HelaGSE14283 112527190 112527221 31 0
Oct1 HelaGSE14283 112536534 112536565 31 0
Oct1 HelaGSE14283 112558431 112558476 45 0
Oct1 HelaGSE14283 112564662 112564695 33 0
Oct1 HelaGSE14283 112565039 112565072 33 0
Oct1 HelaGSE14283 112627919 112627950 31 0
Oct1 HelaGSE14283 112637465 112637496 31 0
Oct4 hESGSE21916 112433728 112434194 466 0
RARA MCF7GSE15244 112566480 112567615 1135 0
RARA MCF7GSE15244 112588001 112588725 724 0
Rb QuiescentGSE19898 112575890 112576033 143 0
Rb shRbSenescenceGSE19898 112483765 112484136 371 0
Sox2 hESGSE18292 112444708 112445197 489 0
TFAP2C MCF7GSE21234 112456302 112456666 364 0
TFAP2C MCF7GSE21234 112568106 112568525 419 0
USF1 HepG2E 112621629 112621798 169 0
p130 QuiescentGSE19898 112431258 112431462 204 0
p63 keratinocytesGSE17611 112408327 112409065 738 0
p63 keratinocytesGSE17611 112480895 112481687 792 0
p63 keratinocytesGSE17611 112509029 112510035 1006 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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