Annotation Detail for MCL1
Basic Information Top
| Gene Symbol: | MCL1 ( BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S,MGC104264,MGC1839,Mcl-1,TM,bcl2-L-3,mcl1/EAT ) |
|---|---|
| Gene Full Name: | myeloid cell leukemia sequence 1 (BCL2-related) |
| Band: | 1q21.2 |
| Quick Links | Entrez ID:4170; OMIM: 159552; Uniprot ID:MCL1_HUMAN; ENSEMBL ID: ENSG00000143384; HGNC ID: 6943 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 121 | Phosphoserine. | |
| 163 | Phosphothreonine; by MAPK. | |
| 223 | BH3. | |
| 272 | BH1. | |
| 319 | BH2. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 5 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 |
| 40 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 |
| 121 | Phosphoserine. | Swiss-Prot 53.0 |
| 136 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 |
| 163 | Phosphothreonine (by MAPK). | Swiss-Prot 53.0 |
| 163 | Phosphothreonine (MAPK1;MAPK3) | Phospho.ELM 6.0 |
| 194 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 |
| 197 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 64 | Phosphoserine(IKK) | HMM predict |
| 64 | Phosphoserine(ATM) | HMM predict |
| 64 | O-linked | HMM predict |
| 64 | O-linked | HMM predict |
| 67 | Phosphoserine(IKK) | HMM predict |
| 67 | O-linked | HMM predict |
| 68 | O-linked | HMM predict |
| 70 | Phosphothreonine(CDC2) | HMM predict |
| 70 | Phosphothreonine(CDK) | HMM predict |
| 70 | Phosphothreonine(MAPK) | HMM predict |
| 92 | Phosphothreonine(MAPK) | HMM predict |
| 121 | Phosphoserine(MAPK) | HMM predict |
| 129 | Phosphotyrosine(Syk) | HMM predict |
| 129 | Phosphotyrosine(INSR) | HMM predict |
| 129 | Phosphotyrosine(EGFR) | HMM predict |
| 129 | Sulfotyrosine | HMM predict |
| 152 | N-linked | HMM predict |
| 153 | N-linked | HMM predict |
| 159 | Phosphoserine(IKK) | HMM predict |
| 159 | O-linked | HMM predict |
| 162 | O-linked | HMM predict |
| 163 | Phosphothreonine(CDK) | HMM predict |
| 163 | O-linked | HMM predict |
| 163 | Phosphothreonine(MAPK) | HMM predict |
| 163 | Phosphothreonine(CDC2) | HMM predict |
| 212 | Phosphothreonine(PKC) | HMM predict |
| 245 | Phosphoserine(CK1) | HMM predict |
- RefSeq ID: NM_182763
- Location:chr1 148813660-148818759
- strand:-
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| H3ac | HepG2 | E | 148819166 | 148819436 | 270 | 542 |
| Oct1 | Hela | GSE14283 | 148819810 | 148819846 | 36 | 1069 |
| SRF | GMO | GSE8489 | 148818972 | 148819436 | 464 | 445 |
| SRF | Hela | GSE8489 | 148818837 | 148819436 | 599 | 377 |
| SRF | k562 | GSE8489 | 148819046 | 148819436 | 390 | 482 |
| hScc1 | Bcell | GSE12603 | 148818362 | 148819202 | 840 | 23 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| TFAP2C | MCF7 | GSE21234 | 148807234 | 148807722 | 488 | 6183 |
| VDR | GM10855-stim | GSE22484 | 148798592 | 148819643 | 21051 | 4543 |
| VDR | GM10861-stim | GSE22484 | 148798603 | 148819759 | 21156 | 4480 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | G2 | GSE9613 | 148818289 | 148818715 | 426 | 0 |
| FoxA1 | MCF7 | MACSdata | 148814971 | 148815260 | 289 | 0 |
| H3K4me2 | HCT116 | GSE10453 | 148816698 | 148817709 | 1011 | 0 |
| H3K4me3 | colorectal | cancer | 148816556 | 148818094 | 1538 | 0 |
| H3ac | HepG2 | E | 148815550 | 148816308 | 758 | 0 |
| H3ac | HepG2 | E | 148816605 | 148818061 | 1456 | 0 |
| Myc | hES | GSE17917 | 148818191 | 148818545 | 354 | 0 |
| NFkBII | GM15510 | GSE19485 | 148817393 | 148819699 | 2306 | 0 |
| PHF8 | 293T | GSE20725 | 148817872 | 148819559 | 1687 | 0 |
| Pol2 | GM12878 | GSE19551 | 148816779 | 148818879 | 2100 | 0 |
| RARA | MCF7 | GSE15244 | 148817057 | 148817911 | 854 | 0 |
| RARG | MCF7 | GSE15244 | 148817294 | 148817987 | 693 | 0 |
| SRF | Hela | GSE8489 | 148815869 | 148818190 | 2321 | 0 |
| SRF | k562 | GSE8489 | 148815980 | 148818094 | 2114 | 0 |
| TAF | Hela | GSE8489 | 148816234 | 148817987 | 1753 | 0 |
| TAF | k562 | GSE8489 | 148814823 | 148818094 | 3271 | 0 |
| hScc1 | Bcell | GSE12603 | 148817381 | 148817947 | 566 | 0 |
| hScc1 | CdLS | GSE12603 | 148816698 | 148818748 | 2050 | 0 |
| p130 | Senescent | GSE19898 | 148813851 | 148814088 | 237 | 0 |
| p130 | S | GSE7516 | 148817323 | 148817947 | 624 | 0 |
| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-let-7a | hsa-let-7a-1 | 9 | 20347499 |
| hsa-let-7a | hsa-let-7a-2 | 11 | 20347499 |
| hsa-let-7a | hsa-let-7a-3 | 22 | 20347499 |
| hsa-let-7a* | hsa-let-7a-1 | 9 | 20347499 |
| hsa-let-7a* | hsa-let-7a-3 | 22 | 20347499 |
| hsa-let-7b | hsa-let-7b | 22 | 20347499 |
| hsa-let-7b* | hsa-let-7b | 22 | 20347499 |
| hsa-let-7c | hsa-let-7c | 21 | 20347499 |
| hsa-let-7c | hsa-let-7c | 21 | 17891175 |
| hsa-let-7c* | hsa-let-7c | 21 | 20347499 |
| hsa-let-7c* | hsa-let-7c | 21 | 17891175 |
| hsa-let-7d | hsa-let-7d | 9 | 20347499 |
| hsa-let-7d* | hsa-let-7d | 9 | 20347499 |
| hsa-let-7e | hsa-let-7e | 19 | 20347499 |
| hsa-let-7e* | hsa-let-7e | 19 | 20347499 |
| hsa-let-7f | hsa-let-7f-1 | 9 | 20347499 |
| hsa-let-7f | hsa-let-7f-2 | X | 20347499 |
| hsa-let-7f-1* | hsa-let-7f-1 | 9 | 20347499 |
| hsa-let-7f-2* | hsa-let-7f-2 | X | 20347499 |
| hsa-let-7g | hsa-let-7g | 3 | 20347499 |
| hsa-let-7g* | hsa-let-7g | 3 | 20347499 |
| hsa-let-7i | hsa-let-7i | 12 | 20347499 |
| hsa-let-7i* | hsa-let-7i | 12 | 20347499 |
| hsa-miR-101 | hsa-mir-101-1 | 1 | 20965124 |
| hsa-miR-101 | hsa-mir-101-2 | 9 | 20965124 |
| hsa-miR-101 | hsa-mir-101-1 | 1 | 20712078 |
| hsa-miR-101 | hsa-mir-101-2 | 9 | 20712078 |
| hsa-miR-101 | hsa-mir-101-1 | 1 | 19155302 |
| hsa-miR-101 | hsa-mir-101-2 | 9 | 19155302 |
| hsa-miR-101 | hsa-mir-101-1 | 1 | 19074828 |
| hsa-miR-101 | hsa-mir-101-2 | 9 | 19074828 |
| hsa-miR-106b | hsa-mir-106b | 7 | 19096009 |
| hsa-miR-106b* | hsa-mir-106b | 7 | 19096009 |
| hsa-miR-10a | hsa-mir-10a | 17 | 19074828 |
| hsa-miR-10a* | hsa-mir-10a | 17 | 19074828 |
| hsa-miR-125b | hsa-mir-125b-1 | 11 | 17891175 |
| hsa-miR-125b | hsa-mir-125b-2 | 21 | 17891175 |
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 20056941 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 20056941 |
| hsa-miR-133b | hsa-mir-133b | 6 | 19654003 |
| hsa-miR-133b | hsa-mir-133b | 6 | 20056941 |
| hsa-miR-137 | hsa-mir-137 | 1 | 18381414 |
| hsa-miR-145 | hsa-mir-145 | 5 | 17891175 |
| hsa-miR-145* | hsa-mir-145 | 5 | 17891175 |
| hsa-miR-150 | hsa-mir-150 | 19 | 19074828 |
| hsa-miR-150* | hsa-mir-150 | 19 | 19074828 |
| hsa-miR-151-3p | hsa-mir-151 | 8 | 19074828 |
| hsa-miR-151-5p | hsa-mir-151 | 8 | 19074828 |
| hsa-miR-153 | hsa-mir-153-1 | 2 | 21213215 |
| hsa-miR-153 | hsa-mir-153-2 | 7 | 21213215 |
| hsa-miR-153 | hsa-mir-153-1 | 2 | 19676043 |
| hsa-miR-153 | hsa-mir-153-2 | 7 | 19676043 |
| hsa-miR-15a | hsa-mir-15a | 13 | 19347736 |
| hsa-miR-15a | hsa-mir-15a | 13 | 18362358 |
| hsa-miR-15a* | hsa-mir-15a | 13 | 19347736 |
| hsa-miR-15a* | hsa-mir-15a | 13 | 18362358 |
| hsa-miR-16 | hsa-mir-16-1 | 13 | 20643754 |
| hsa-miR-16 | hsa-mir-16-2 | 3 | 20643754 |
| hsa-miR-16 | hsa-mir-16-1 | 13 | 19347736 |
| hsa-miR-16 | hsa-mir-16-2 | 3 | 19347736 |
| hsa-miR-16 | hsa-mir-16-1 | 13 | 18362358 |
| hsa-miR-16 | hsa-mir-16-2 | 3 | 18362358 |
| hsa-miR-16-1* | hsa-mir-16-1 | 13 | 19347736 |
| hsa-miR-16-1* | hsa-mir-16-1 | 13 | 18362358 |
| hsa-miR-17 | hsa-mir-17 | 13 | 20643754 |
| hsa-miR-17 | hsa-mir-17 | 13 | 19347736 |
| hsa-miR-17* | hsa-mir-17 | 13 | 20643754 |
| hsa-miR-17* | hsa-mir-17 | 13 | 19347736 |
| hsa-miR-181a | hsa-mir-181a-2 | 9 | 20693279 |
| hsa-miR-181a | hsa-mir-181a-1 | 1 | 20693279 |
| hsa-miR-181a* | hsa-mir-181a-1 | 1 | 20693279 |
| hsa-miR-181a-2* | hsa-mir-181a-2 | 9 | 20693279 |
| hsa-miR-181b | hsa-mir-181b-1 | 1 | 20693279 |
| hsa-miR-181b | hsa-mir-181b-2 | 9 | 20693279 |
| hsa-miR-181c | hsa-mir-181c | 19 | 20693279 |
| hsa-miR-181c* | hsa-mir-181c | 19 | 20693279 |
| hsa-miR-181d | hsa-mir-181d | 19 | 20693279 |
| hsa-miR-192 | hsa-mir-192 | 11 | 19074875 |
| hsa-miR-192* | hsa-mir-192 | 11 | 19074875 |
| hsa-miR-193a-3p | hsa-mir-193a | 17 | 18381414 |
| hsa-miR-193a-5p | hsa-mir-193a | 17 | 18381414 |
| hsa-miR-193b | hsa-mir-193b | 16 | 20103677 |
| hsa-miR-193b* | hsa-mir-193b | 16 | 20103677 |
| hsa-miR-194 | hsa-mir-194-1 | 1 | 19074875 |
| hsa-miR-194 | hsa-mir-194-2 | 11 | 19074875 |
| hsa-miR-203 | hsa-mir-203 | 14 | 18381414 |
| hsa-miR-204 | hsa-mir-204 | 9 | 19074875 |
| hsa-miR-204 | hsa-mir-204 | 9 | 19070389 |
| hsa-miR-215 | hsa-mir-215 | 1 | 19074875 |
| hsa-miR-29a | hsa-mir-29a | 7 | 20643754 |
| hsa-miR-29a | hsa-mir-29a | 7 | 20164119 |
| hsa-miR-29a | hsa-mir-29a | 7 | 19850741 |
| hsa-miR-29a | hsa-mir-29a | 7 | 19347736 |
| hsa-miR-29a | hsa-mir-29a | 7 | 20041405 |
| hsa-miR-29a* | hsa-mir-29a | 7 | 20643754 |
| hsa-miR-29a* | hsa-mir-29a | 7 | 20164119 |
| hsa-miR-29a* | hsa-mir-29a | 7 | 19850741 |
| hsa-miR-29a* | hsa-mir-29a | 7 | 19347736 |
| hsa-miR-29a* | hsa-mir-29a | 7 | 20041405 |
| hsa-miR-29b | hsa-mir-29b-1 | 7 | 20657750 |
| hsa-miR-29b | hsa-mir-29b-2 | 1 | 20657750 |
| hsa-miR-29b | hsa-mir-29b-1 | 7 | 20643754 |
| hsa-miR-29b | hsa-mir-29b-2 | 1 | 20643754 |
| hsa-miR-29b | hsa-mir-29b-1 | 7 | 20164119 |
| hsa-miR-29b | hsa-mir-29b-2 | 1 | 20164119 |
| hsa-miR-29b | hsa-mir-29b-1 | 7 | 19850741 |
| hsa-miR-29b | hsa-mir-29b-2 | 1 | 19850741 |
| hsa-miR-29b | hsa-mir-29b-1 | 7 | 19347736 |
| hsa-miR-29b | hsa-mir-29b-2 | 1 | 19347736 |
| hsa-miR-29b | hsa-mir-29b-1 | 7 | 20041405 |
| hsa-miR-29b | hsa-mir-29b-2 | 1 | 20041405 |
| hsa-miR-29b | hsa-mir-29b-1 | 7 | 17404574 |
| hsa-miR-29b | hsa-mir-29b-2 | 1 | 17404574 |
| hsa-miR-29b-1* | hsa-mir-29b-1 | 7 | 20643754 |
| hsa-miR-29b-1* | hsa-mir-29b-1 | 7 | 20164119 |
| hsa-miR-29b-1* | hsa-mir-29b-1 | 7 | 19850741 |
| hsa-miR-29b-1* | hsa-mir-29b-1 | 7 | 19347736 |
| hsa-miR-29b-1* | hsa-mir-29b-1 | 7 | 20041405 |
| hsa-miR-29b-2* | hsa-mir-29b-2 | 1 | 20643754 |
| hsa-miR-29b-2* | hsa-mir-29b-2 | 1 | 20164119 |
| hsa-miR-29b-2* | hsa-mir-29b-2 | 1 | 19850741 |
| hsa-miR-29b-2* | hsa-mir-29b-2 | 1 | 19347736 |
| hsa-miR-29b-2* | hsa-mir-29b-2 | 1 | 20041405 |
| hsa-miR-29c | hsa-mir-29c | 1 | 20643754 |
| hsa-miR-29c | hsa-mir-29c | 1 | 20164119 |
| hsa-miR-29c | hsa-mir-29c | 1 | 19850741 |
| hsa-miR-29c | hsa-mir-29c | 1 | 19347736 |
| hsa-miR-29c | hsa-mir-29c | 1 | 20041405 |
| hsa-miR-29c* | hsa-mir-29c | 1 | 20643754 |
| hsa-miR-29c* | hsa-mir-29c | 1 | 20164119 |
| hsa-miR-29c* | hsa-mir-29c | 1 | 19850741 |
| hsa-miR-29c* | hsa-mir-29c | 1 | 19347736 |
| hsa-miR-29c* | hsa-mir-29c | 1 | 20041405 |
| hsa-miR-320a | hsa-mir-320a | 8 | 19096009 |
| hsa-miR-320a | hsa-mir-320a | 8 | 19070389 |
| hsa-miR-320b | hsa-mir-320b-1 | 1 | 19096009 |
| hsa-miR-320b | hsa-mir-320b-2 | 1 | 19096009 |
| hsa-miR-320c | hsa-mir-320c-1 | 18 | 19096009 |
| hsa-miR-320c | hsa-mir-320c-2 | 18 | 19096009 |
| hsa-miR-320d | hsa-mir-320d-1 | 13 | 19096009 |
| hsa-miR-320d | hsa-mir-320d-2 | X | 19096009 |
| hsa-miR-34a | hsa-mir-34a | 1 | 19347736 |
| hsa-miR-34a | hsa-mir-34a | 1 | 19074875 |
| hsa-miR-34a* | hsa-mir-34a | 1 | 19347736 |
| hsa-miR-34a* | hsa-mir-34a | 1 | 19074875 |
| hsa-miR-34b | hsa-mir-34b | 11 | 18381414 |
| hsa-miR-34b* | hsa-mir-34b | 11 | 18381414 |
| hsa-miR-512-3p | hsa-mir-512-1 | 19 | 19503096 |
| hsa-miR-512-3p | hsa-mir-512-2 | 19 | 19503096 |
| hsa-miR-512-5p | hsa-mir-512-1 | 19 | 19503096 |
| hsa-miR-512-5p | hsa-mir-512-2 | 19 | 19503096 |
| hsa-miR-96 | hsa-mir-96 | 7 | 19074828 |
| hsa-miR-96* | hsa-mir-96 | 7 | 19074828 |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 584 | Unknown | TRUE | miR-29b | Mcl1 | Reporter assay | 17404574 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000143384 | G1/S phase transition | n_a | n_a | "epithelium, lymphoblast, leukocyte, lymphocyte, macrophage, muscle cell" | "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma" |
Cis-Nats regulation