AutismKB 2.0

Annotation Detail for MCM2


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Basic Information Top
Gene Symbol:MCM2 ( BM28,CCNL1,CDCL1,D3S3194,KIAA0030,MGC10606,MITOTIN,cdc19 )
Gene Full Name: minichromosome maintenance complex component 2
Band: 3q21.3
Quick LinksEntrez ID:4171; OMIM: 116945; Uniprot ID:MCM2_HUMAN; ENSEMBL ID: ENSG00000073111; HGNC ID: 6944
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
4Phosphoserine.
5Phosphoserine.
7Phosphoserine.
12Phosphoserine (By similarity).
13Phosphoserine.
25Phosphothreonine.
26Phosphoserine.
27Phosphoserine.
32Phosphoserine.
39Phosphothreonine.
40Phosphoserine; by CDC7.
41Phosphoserine.
53Phosphoserine; by CDC7.
59Phosphothreonine.
106Phosphothreonine.
108Phosphoserine; by ATR.
139Phosphoserine.
216N6-acetyllysine.
381Phosphoserine.
658Arginine finger.
896N6-acetyllysine.
Location(AA) Modifications Resource
13Phosphoserine.Swiss-Prot 53.0
13PhosphoserinePhospho.ELM 6.0
26Phosphoserine (By similarity).Swiss-Prot 53.0
26PhosphoserinePhospho.ELM 6.0
27PhosphoserinePhospho.ELM 6.0
27Phosphoserine.Swiss-Prot 53.0
35PhosphothreoninePhospho.ELM 6.0
39PhosphothreoninePhospho.ELM 6.0
39Phosphothreonine.Swiss-Prot 53.0
40PhosphoserinePhospho.ELM 6.0
40Phosphoserine.Swiss-Prot 53.0
41Phosphoserine.Swiss-Prot 53.0
41PhosphoserinePhospho.ELM 6.0
106Phosphothreonine.Swiss-Prot 53.0
106PhosphothreoninePhospho.ELM 6.0
108Phosphoserine (by ATR).Swiss-Prot 53.0
139PhosphoserinePhospho.ELM 6.0
139Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
7O-linkedHMM predict
9O-linkedHMM predict
27Phosphoserine(CDK)HMM predict
27PhosphoserineHMM predict
27Phosphoserine(CDC2)HMM predict
41Phosphoserine(CDC2)HMM predict
81Phosphotyrosine(EGFR)HMM predict
90Phosphotyrosine(INSR)HMM predict
108Phosphoserine(ATM)HMM predict
139Phosphoserine(CK2)HMM predict
139Phosphoserine(CK2)HMM predict
139Phosphoserine(ATM)HMM predict
158Phosphothreonine(PKA)HMM predict
158Phosphothreonine(CK2)HMM predict
370Phosphotyrosine(SRC)HMM predict
370Phosphotyrosine(Syk)HMM predict
381Phosphoserine(CDC2)HMM predict
552O-linkedHMM predict
599Phosphoserine(CK1)HMM predict
608Phosphoserine(IKK)HMM predict
698N-linkedHMM predict
754Phosphoserine(PKG)HMM predict
759Phosphoserine(IKK)HMM predict
876N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004526
  • Location:chr3 128799942-128823963
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 128791289 128793029 1740 7784
CTCF G2GSE9613 128798201 128798331 130 1677
CTCF G2GSE9613 128799645 128799989 344 126
Fos K562GSE19551 128792111 128792545 434 7615
Gata1 K562GSE18868 128796818 128797291 473 2888
Gata2 K562GSE18868 128796766 128797306 540 2907
H3K4me2 HCT116GSE10453 128797959 128798331 372 1798
H3ac HepG2E 128797959 128798331 372 1798
H3ac HepG2E 128798676 128799318 642 946
NFkBII GM15510GSE19485 128799250 128800629 1379 3
Rb GrowingGSE19898 128799759 128800051 292 38
Rb shRbQuiescentGSE19898 128799734 128800131 397 10
Rb shRbSenescenceGSE19898 128799703 128800078 375 52
TFAP2C MCF7GSE21234 128799402 128800052 650 216
USF1 HepG2E 128797959 128798331 372 1798
USF1 HepG2E 128798676 128799318 642 946
hScc1 BcellGSE12603 128791212 128793029 1817 7822
hScc1 CdLSGSE12603 128792334 128792771 437 7390
hScc1 G2GSE9613 128792011 128792802 791 7536
hScc1 G2GSE9613 128799645 128799785 140 228
p130 shRbSenescentGSE19898 128790919 128791196 277 8885
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 128824664 128825210 546 974
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 128806205 128806662 457 0
CTCF G2GSE9613 128808255 128808694 439 0
CTCF G2GSE9613 128818643 128819019 376 0
FOXA1 MCF7GSE15244 128800489 128801348 859 0
H3ac HepG2E 128799954 128801509 1555 0
H3ac HepG2E 128801839 128802360 521 0
LIN9 SGSE7516 128799645 128800277 632 0
Myc K562GSE19551 128799573 128800404 831 0
PHF8 HeLaGSE20725 128799395 128800640 1245 0
RARG MCF7GSE15244 128800416 128801434 1018 0
Rb QuiescentGSE19898 128799799 128800143 344 0
Rb SenescentGSE19898 128799704 128800301 597 0
TAF k562GSE8489 128800160 128800810 650 0
USF1 HepG2E 128799645 128801509 1864 0
hScc1 BcellGSE12603 128822154 128822581 427 0
p130 QuiescentGSE19898 128799815 128800436 621 0
p130 SenescentGSE19898 128799717 128800440 723 0
p130 shRbQuiescentGSE19898 128799612 128800326 714 0
p130 shRbSenescentGSE19898 128799682 128800385 703 0
p130 SGSE7516 128799645 128800336 691 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7g hsa-let-7g 3 21293479
hsa-let-7g hsa-let-7g 3 21293479
hsa-let-7g* hsa-let-7g 3 21293479
hsa-let-7g* hsa-let-7g 3 21293479
hsa-miR-126 hsa-mir-126 9 21293479
hsa-miR-126 hsa-mir-126 9 21293479
hsa-miR-126* hsa-mir-126 9 21293479
hsa-miR-126* hsa-mir-126 9 21293479
hsa-miR-1296 hsa-mir-1296 10 20332239
hsa-miR-1296 hsa-mir-1296 10 20332239
hsa-miR-196a hsa-mir-196a-1 17 21293479
hsa-miR-196a hsa-mir-196a-2 12 21293479
hsa-miR-196a hsa-mir-196a-1 17 21293479
hsa-miR-196a hsa-mir-196a-2 12 21293479
hsa-miR-31 hsa-mir-31 9 21293479
hsa-miR-31 hsa-mir-31 9 21293479
hsa-miR-31* hsa-mir-31 9 21293479
hsa-miR-31* hsa-mir-31 9 21293479
hsa-miR-338-3p hsa-mir-338 17 21293479
hsa-miR-338-3p hsa-mir-338 17 21293479
hsa-miR-338-5p hsa-mir-338 17 21293479
hsa-miR-338-5p hsa-mir-338 17 21293479
hsa-miR-7 hsa-mir-7-1 9 21293479
hsa-miR-7 hsa-mir-7-2 15 21293479
hsa-miR-7 hsa-mir-7-3 19 21293479
hsa-miR-7 hsa-mir-7-1 9 21293479
hsa-miR-7 hsa-mir-7-2 15 21293479
hsa-miR-7 hsa-mir-7-3 19 21293479
hsa-miR-98 hsa-mir-98 X 21293479
hsa-miR-98 hsa-mir-98 X 21293479
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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