AutismKB 2.0

Annotation Detail for MCM4


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Basic Information Top
Gene Symbol:MCM4 ( CDC21,CDC54,MGC33310,P1-CDC21,hCdc21 )
Gene Full Name: minichromosome maintenance complex component 4
Band: 8q11.21
Quick LinksEntrez ID:4173; OMIM: 602638; Uniprot ID:MCM4_HUMAN; ENSEMBL ID: ENSG00000104738; HGNC ID: 6947
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
19Phosphothreonine.
26Phosphoserine.
31Phosphoserine.
32Phosphoserine.
34Phosphoserine.
54Phosphoserine.
102Phosphothreonine.
105Phosphoserine.
110Phosphothreonine.
120Phosphoserine.
131Phosphoserine.
142Phosphoserine.
145Phosphoserine.
220N6-acetyllysine.
326Phosphoserine.
450N6-acetyllysine.
645Arginine finger.
Location(AA) Modifications Resource
7PhosphothreoninePhospho.ELM 6.0
19Phosphothreonine.Swiss-Prot 53.0
26Phosphoserine.Swiss-Prot 53.0
32Phosphoserine.Swiss-Prot 53.0
32Phosphoserine (CDK2)Phospho.ELM 6.0
54Phosphoserine (CHK1;CDK2)Phospho.ELM 6.0
110Phosphothreonine (CDK2)Phospho.ELM 6.0
120Phosphoserine.Swiss-Prot 53.0
120PhosphoserinePhospho.ELM 6.0
131PhosphoserinePhospho.ELM 6.0
131Phosphoserine.Swiss-Prot 53.0
142Phosphoserine.Swiss-Prot 53.0
142PhosphoserinePhospho.ELM 6.0
145PhosphoserinePhospho.ELM 6.0
145Phosphoserine.Swiss-Prot 53.0
326Phosphoserine.Swiss-Prot 53.0
326PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
7Phosphothreonine(CDC2)HMM predict
7Phosphothreonine(MAPK)HMM predict
7Phosphothreonine(CDK)HMM predict
17MethylarginineHMM predict
19O-linkedHMM predict
23Phosphothreonine(CDK)HMM predict
23Phosphothreonine(MAPK)HMM predict
23Phosphothreonine(CDC2)HMM predict
23Phosphothreonine(PKC)HMM predict
26Phosphoserine(MAPK)HMM predict
31Phosphoserine(CK1)HMM predict
31Phosphoserine(IKK)HMM predict
32Phosphoserine(CDK)HMM predict
32PhosphoserineHMM predict
44Phosphoserine(CK1)HMM predict
54Phosphoserine(MAPK)HMM predict
61Phosphoserine(MAPK)HMM predict
71Phosphoserine(CDC2)HMM predict
92Phosphotyrosine(INSR)HMM predict
97O-linkedHMM predict
108MethylarginineHMM predict
110Phosphothreonine(CDK)HMM predict
110Phosphothreonine(CDC2)HMM predict
249Phosphotyrosine(EGFR)HMM predict
342N-linkedHMM predict
366Phosphothreonine(MAPK)HMM predict
389N-linkedHMM predict
406O-linkedHMM predict
459Phosphotyrosine(EGFR)HMM predict
580N-linkedHMM predict
585Phosphoserine(CK1)HMM predict
707Phosphoserine(ATM)HMM predict
750Phosphoserine(PKG)HMM predict
793Phosphothreonine(PKC)HMM predict
794Phosphoserine(PKC)HMM predict
815PhosphothreonineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005914
  • Location:chr8 49036046-49052620
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 49035134 49036251 1117 354
LIN9 G0GSE7516 49035134 49036289 1155 335
LIN9 SGSE7516 49035284 49036217 933 296
PHF8 HeLaGSE20725 49034556 49036965 2409 286
PHF8 Hs68plusFBSGSE20725 49034647 49037183 2536 132
Rb GrowingGSE19898 49035683 49036169 486 121
Rb shRbQuiescentGSE19898 49035636 49036200 564 129
Rb shRbSenescenceGSE19898 49035576 49036181 605 168
p130 G0GSE7516 49035446 49036217 771 215
p130 SGSE7516 49035315 49036217 902 281
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 49066435 49066759 324 13977
ER E2-MCF7GSE14664 49058050 49058088 38 5449
Oct1 H2O2-HelaGSE14283 49061981 49062008 27 9374
Oct1 HelaGSE14283 49061980 49062008 28 9374
TFAP2C MCF7GSE21234 49062492 49063056 564 10154
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 49036171 49036483 312 0
CTCF G2GSE9613 49041092 49041364 272 0
CTCF G2GSE9613 49047957 49048160 203 0
H3K4me3 colorectalcancer 49035946 49036251 305 0
H3ac HepG2E 49036483 49038258 1775 0
NRSF pAbJurkat 49040987 49041424 437 0
TFAP2C MCF7GSE21234 49036382 49036962 580 0
TFAP2C MCF7GSE21234 49042338 49042729 391 0
hScc1 BcellGSE12603 49049337 49049601 264 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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