AutismKB 2.0

Annotation Detail for MCM6


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Basic Information Top
Gene Symbol:MCM6 ( MCG40308,Mis5,P105MCM )
Gene Full Name: minichromosome maintenance complex component 6
Band: 2q21.3
Quick LinksEntrez ID:4175; OMIM: 601806; Uniprot ID:MCM6_HUMAN; ENSEMBL ID: ENSG00000076003; HGNC ID: 6949
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
271Phosphoserine.
531Arginine finger.
599N6-acetyllysine.
762Phosphoserine.
775N6-acetyllysine.
791Phosphothreonine.
Location(AA) Modifications Resource
271Phosphoserine.Swiss-Prot 53.0
762Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
84Phosphotyrosine(Syk)HMM predict
111Phosphotyrosine(Jak)HMM predict
111Phosphotyrosine(EGFR)HMM predict
158S-palmitoylHMM predict
174Phosphotyrosine(Jak)HMM predict
196N-linkedHMM predict
259Phosphothreonine(MAPK)HMM predict
266Phosphothreonine(PKC)HMM predict
301S-palmitoylHMM predict
302S-palmitoylHMM predict
424Phosphoserine(PKG)HMM predict
439PhosphoserineHMM predict
515Phosphoserine(CK1)HMM predict
762Phosphoserine(CK1)HMM predict
804PhosphoserineHMM predict
804Phosphoserine(CK2)HMM predict
805Phosphotyrosine(Syk)HMM predict
810Phosphotyrosine(Jak)HMM predict
810Phosphotyrosine(Syk)HMM predict
810Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005915
  • Location:chr2 136313673-136350480
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 136350304 136350984 680 164
LIN9 G0GSE7516 136350243 136350959 716 121
LIN9 SGSE7516 136350172 136350855 683 33
Nanog hESGSE18292 136365433 136365701 268 15087
Oct1 H2O2-HelaGSE14283 136357422 136357449 27 6955
Rb GrowingGSE19898 136350400 136350757 357 98
Rb QuiescentGSE19898 136350398 136350859 461 148
Rb SenescentGSE19898 136350380 136350909 529 164
Rb shRbQuiescentGSE19898 136350407 136350724 317 85
Rb shRbSenescenceGSE19898 136350360 136350704 344 52
TFAP2C MCF7GSE21234 136350330 136351219 889 294
p130 QuiescentGSE19898 136350305 136351004 699 174
p130 shRbQuiescentGSE19898 136350326 136350968 642 167
p130 shRbSenescentGSE19898 136350337 136350978 641 177
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 136349539 136350099 560 0
H3K4me2 HCT116GSE10453 136348029 136348385 356 0
Nanog hESGSE18292 136348127 136348513 386 0
Oct1 HelaGSE14283 136322113 136322147 34 0
PHF8 HeLaGSE20725 136349471 136350948 1477 0
SRF HelaGSE8489 136338185 136338562 377 0
TAF HelaGSE8489 136338185 136338562 377 0
TAF k562GSE8489 136348067 136348485 418 0
TAF k562GSE8489 136349539 136349720 181 0
hScc1 BcellGSE12603 136349720 136350545 825 0
p130 SenescentGSE19898 136349807 136350786 979 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018