AutismKB 2.0

Annotation Detail for ME1


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Basic Information Top
Gene Symbol:ME1 ( HUMNDME,MES )
Gene Full Name: malic enzyme 1, NADP(+)-dependent, cytosolic
Band: 6q14.2
Quick LinksEntrez ID:4199; OMIM: 154250; Uniprot ID:MAOX_HUMAN; ENSEMBL ID: ENSG00000065833; HGNC ID: 6983
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
60N6-acetyllysine.
84N6-acetyllysine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
1AcetylmethionineHMM predict
11Phosphothreonine(PKA)HMM predict
221Phosphotyrosine(EGFR)HMM predict
346Phosphoserine(PKG)HMM predict
408N-linkedHMM predict
411Phosphoserine(IKK)HMM predict
453N-linkedHMM predict
454N-linkedHMM predict
505Phosphothreonine(PKC)HMM predict
522Phosphotyrosine(EGFR)HMM predict
549Phosphotyrosine(Jak)HMM predict
549Phosphotyrosine(Syk)HMM predict
549SulfotyrosineHMM predict
557TyrosineHMM predict
558Phosphoserine(IKK)HMM predict
558SerineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002395
  • Location:chr6 83976830-84197497
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 84197333 84198694 1361 516
FoxA1 MCF7MACSdata 84200991 84201161 170 3579
NFkBII GM10847GSE19485 84196870 84198203 1333 39
Nanog hESGSE18292 84209879 84210232 353 12558
Oct1 HelaGSE14283 84204972 84205030 58 7504
Oct1 HelaGSE14283 84206141 84206172 31 8659
Oct1 HelaGSE14283 84206525 84206563 38 9047
Oct1 HelaGSE14283 84206886 84206919 33 9405
p130 shRbQuiescentGSE19898 84197573 84197976 403 277
p130 shRbSenescentGSE19898 84197614 84197879 265 249
p63 keratinocytesGSE17611 84203102 84203741 639 5924
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 84065207 84065414 207 0
CTCF CD4GSE12889 83981573 83981951 378 0
CTCF CD4SISSRdata 83981573 83981951 378 0
CTCF G2GSE9613 83988093 83988688 595 0
CTCF G2GSE9613 84131337 84131511 174 0
CTCF G2GSE9613 84158663 84159440 777 0
CTCF G2GSE9613 84197179 84197632 453 0
ER E2-MCF7GSE14664 84013776 84013808 32 0
ER E2-MCF7GSE14664 84023496 84023528 32 0
ER Fulvestrant-MCF7GSE14664 84063089 84063122 33 0
Fos K562GSE19551 84037739 84038201 462 0
FoxA1 MCF7MACSdata 83981750 83981914 164 0
Myc K562GSE19551 83981613 83981887 274 0
Oct1 H2O2-HelaGSE14283 83978135 83978163 28 0
Oct1 H2O2-HelaGSE14283 83979693 83979727 34 0
Oct1 H2O2-HelaGSE14283 83982991 83983019 28 0
Oct1 H2O2-HelaGSE14283 84005471 84005500 29 0
Oct1 H2O2-HelaGSE14283 84020396 84020425 29 0
Oct1 H2O2-HelaGSE14283 84032108 84032141 33 0
Oct1 H2O2-HelaGSE14283 84054583 84054614 31 0
Oct1 HelaGSE14283 83979690 83979727 37 0
Oct1 HelaGSE14283 83990390 83990429 39 0
Oct1 HelaGSE14283 84004759 84004789 30 0
Oct1 HelaGSE14283 84011368 84011399 31 0
Oct1 HelaGSE14283 84015540 84015616 76 0
Oct1 HelaGSE14283 84020395 84020424 29 0
Oct1 HelaGSE14283 84030160 84030223 63 0
Oct1 HelaGSE14283 84032109 84032141 32 0
Oct1 HelaGSE14283 84058210 84058254 44 0
Oct1 HelaGSE14283 84058513 84058545 32 0
Oct1 HelaGSE14283 84059753 84059780 27 0
Oct1 HelaGSE14283 84061344 84061372 28 0
Oct1 HelaGSE14283 84063090 84063127 37 0
Oct1 HelaGSE14283 84099580 84099607 27 0
Oct1 HelaGSE14283 84130130 84130161 31 0
Oct1 HelaGSE14283 84135758 84135794 36 0
Oct1 HelaGSE14283 84141609 84141642 33 0
P300 T0-glioblastomaGSE21026 84019180 84019835 655 0
P300 T30-glioblastomaGSE21026 84019170 84019787 617 0
P300 T30-glioblastomaGSE21026 84037628 84038262 634 0
TAF HelaGSE8489 84196256 84196855 599 0
TAF k562GSE8489 84196116 84196783 667 0
hScc1 BcellGSE12603 84159702 84160054 352 0
hScc1 CdLSGSE12603 83988093 83988869 776 0
p130 shRbSenescentGSE19898 84197124 84197420 296 0
p63 keratinocytesGSE17611 84075589 84076362 773 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 15183728
hsa-let-7a hsa-let-7a-2 11 15183728
hsa-let-7a hsa-let-7a-3 22 15183728
hsa-let-7a* hsa-let-7a-1 9 15183728
hsa-let-7a* hsa-let-7a-3 22 15183728
hsa-miR-103 hsa-mir-103-2 20 15183728
hsa-miR-103 hsa-mir-103-1 5 15183728
hsa-miR-124 hsa-mir-124-1 8 15183728
hsa-miR-124 hsa-mir-124-2 8 15183728
hsa-miR-124 hsa-mir-124-3 20 15183728
hsa-miR-124* hsa-mir-124-1 8 15183728
hsa-miR-124* hsa-mir-124-2 8 15183728
hsa-miR-124* hsa-mir-124-3 20 15183728
hsa-miR-130a hsa-mir-130a 11 15183728
hsa-miR-130a* hsa-mir-130a 11 15183728
hsa-miR-134 hsa-mir-134 14 15183728
hsa-miR-135a hsa-mir-135a-1 3 15183728
hsa-miR-135a hsa-mir-135a-2 12 15183728
hsa-miR-135a* hsa-mir-135a-1 3 15183728
hsa-miR-136 hsa-mir-136 14 15183728
hsa-miR-136* hsa-mir-136 14 15183728
hsa-miR-154 hsa-mir-154 14 15183728
hsa-miR-154* hsa-mir-154 14 15183728
hsa-miR-16 hsa-mir-16-1 13 15183728
hsa-miR-16 hsa-mir-16-2 3 15183728
hsa-miR-16-1* hsa-mir-16-1 13 15183728
hsa-miR-16-2* hsa-mir-16-2 3 15183728
hsa-miR-17 hsa-mir-17 13 15183728
hsa-miR-17* hsa-mir-17 13 15183728
hsa-miR-19b hsa-mir-19b-1 13 15183728
hsa-miR-19b hsa-mir-19b-2 X 15183728
hsa-miR-19b-1* hsa-mir-19b-1 13 15183728
hsa-miR-19b-2* hsa-mir-19b-2 X 15183728
hsa-miR-200c hsa-mir-200c 12 15183728
hsa-miR-200c* hsa-mir-200c 12 15183728
hsa-miR-21 hsa-mir-21 17 19150961
hsa-miR-21 hsa-mir-21 17 15183728
hsa-miR-21* hsa-mir-21 17 19150961
hsa-miR-21* hsa-mir-21 17 15183728
hsa-miR-222 hsa-mir-222 X 15183728
hsa-miR-222* hsa-mir-222 X 15183728
hsa-miR-26a hsa-mir-26a-1 3 15183728
hsa-miR-26a hsa-mir-26a-2 12 15183728
hsa-miR-26a-1* hsa-mir-26a-1 3 15183728
hsa-miR-26a-2* hsa-mir-26a-2 12 15183728
hsa-miR-296-3p hsa-mir-296 20 15183728
hsa-miR-296-5p hsa-mir-296 20 15183728
hsa-miR-29a hsa-mir-29a 7 15183728
hsa-miR-29a* hsa-mir-29a 7 15183728
hsa-miR-29b hsa-mir-29b-1 7 15183728
hsa-miR-29b hsa-mir-29b-2 1 15183728
hsa-miR-29b-1* hsa-mir-29b-1 7 15183728
hsa-miR-29b-2* hsa-mir-29b-2 1 15183728
hsa-miR-301a hsa-mir-301a 17 15183728
hsa-miR-302a hsa-mir-302a 4 15183728
hsa-miR-302a* hsa-mir-302a 4 15183728
hsa-miR-302b hsa-mir-302b 4 15183728
hsa-miR-302b* hsa-mir-302b 4 15183728
hsa-miR-302c hsa-mir-302c 4 15183728
hsa-miR-302c* hsa-mir-302c 4 15183728
hsa-miR-302d hsa-mir-302d 4 15183728
hsa-miR-302d* hsa-mir-302d 4 15183728
hsa-miR-367 hsa-mir-367 4 15183728
hsa-miR-367* hsa-mir-367 4 15183728
hsa-miR-369-3p hsa-mir-369 14 15183728
hsa-miR-369-5p hsa-mir-369 14 15183728
hsa-miR-370 hsa-mir-370 14 15183728
hsa-miR-371-3p hsa-mir-371 19 15183728
hsa-miR-371-5p hsa-mir-371 19 15183728
hsa-miR-372 hsa-mir-372 19 15183728
hsa-miR-373 hsa-mir-373 19 15183728
hsa-miR-373* hsa-mir-373 19 15183728
hsa-miR-374a hsa-mir-374a X 15183728
hsa-miR-374a* hsa-mir-374a X 15183728
hsa-miR-376c hsa-mir-376c 0 15183728
hsa-miR-429 hsa-mir-429 1 21233447
hsa-miR-92a hsa-mir-92a-1 13 15183728
hsa-miR-92a hsa-mir-92a-2 X 15183728
hsa-miR-92a-1* hsa-mir-92a-1 13 15183728
hsa-miR-92a-2* hsa-mir-92a-2 X 15183728
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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