AutismKB 2.0

Annotation Detail for MECP2


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Basic Information Top
Gene Symbol:MECP2 ( AUTSX3,DKFZp686A24160,MRX16,MRX79,MRXS13,MRXSL,PPMX,RS,RTS,RTT )
Gene Full Name: methyl CpG binding protein 2 (Rett syndrome)
Band: Xq28
Quick LinksEntrez ID:4204; OMIM: 300005; Uniprot ID:MECP2_HUMAN; ENSEMBL ID: ENSG00000169057; HGNC ID: 6990
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
80Phosphoserine.
116Phosphoserine.
229Phosphoserine (By similarity).
423Phosphoserine (By similarity).
426Phosphoserine.
449N6-acetyllysine.
Location(AA) Modifications Resource
80Phosphoserine.Swiss-Prot 53.0
80PhosphoserinePhospho.ELM 6.0
166PhosphoserinePhospho.ELM 6.0
229Phosphoserine (By similarity).Swiss-Prot 53.0
423Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
65O-linkedHMM predict
65O-linkedHMM predict
68O-linkedHMM predict
68O-linkedHMM predict
68Phosphoserine(IKK)HMM predict
80PhosphoserineHMM predict
164Phosphoserine(CDC2)HMM predict
178Phosphoserine(IKK)HMM predict
178Phosphoserine(CDC2)HMM predict
186MethylarginineHMM predict
188MethylarginineHMM predict
196Phosphothreonine(PKC)HMM predict
216Phosphoserine(CDC2)HMM predict
229Phosphoserine(CDC2)HMM predict
242O-linkedHMM predict
308Phosphothreonine(PKA)HMM predict
311Phosphothreonine(PKA)HMM predict
341Phosphoserine(CDC2)HMM predict
346Phosphoserine(PKG)HMM predict
350Phosphoserine(CDC2)HMM predict
356O-linkedHMM predict
357O-linkedHMM predict
357Phosphoserine(IKK)HMM predict
357PhosphoserineHMM predict
360Phosphoserine(CDK)HMM predict
360Phosphoserine(ATM)HMM predict
360Phosphoserine(CDC2)HMM predict
396O-linkedHMM predict
400O-linkedHMM predict
401Phosphoserine(IKK)HMM predict
401Phosphoserine(ATM)HMM predict
401Phosphoserine(CDK)HMM predict
401Phosphoserine(MAPK)HMM predict
423Phosphoserine(IKK)HMM predict
436Phosphothreonine(PKC)HMM predict
479Phosphothreonine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004992
  • Location:chrX 152940457-153016322
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 153016374 153016859 485 294
Oct1 HelaGSE14283 153035130 153035160 30 18823
SRF HelaGSE8489 153023732 153024258 526 7673
hScc1 BcellGSE12603 153016083 153016569 486 4
p130 SenescentGSE19898 153016554 153016938 384 424
p130 shRbQuiescentGSE19898 153016495 153016895 400 373
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
p130 shRbSenescentGSE19898 152939796 152940089 293 515
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 152969844 152970144 300 0
CTCF CD4SISSRdata 152969844 152970144 300 0
CTCF JurkatGSE12889 152970008 152970124 116 0
CTCF G2GSE9613 152942220 152942433 213 0
CTCF G2GSE9613 152948236 152948646 410 0
CTCF G2GSE9613 152949153 152949541 388 0
CTCF G2GSE9613 152950722 152951874 1152 0
CTCF G2GSE9613 152954823 152954974 151 0
CTCF G2GSE9613 152958542 152958858 316 0
CTCF G2GSE9613 152968710 152970152 1442 0
CTCF G2GSE9613 152975319 152975536 217 0
CTCF G2GSE9613 152979305 152979907 602 0
CTCF G2GSE9613 152983745 152984107 362 0
CTCF G2GSE9613 152994974 152995164 190 0
CTCF G2GSE9613 153016002 153016605 603 0
FOXA1 MCF7GSE15244 152951576 152952170 594 0
FOXA1 MCF7GSE15244 152964947 152965113 166 0
FOXA1 MCF7GSE15244 152968348 152969619 1271 0
H3ac HepG2E 153013797 153015431 1634 0
KLF4 hESGSE17917 153015624 153015903 279 0
Myc K562GSE19551 152975291 152975623 332 0
Nanog hESGSE18292 152955341 152955500 159 0
Oct1 HelaGSE14283 152970894 152970924 30 0
Oct1 HelaGSE14283 153011743 153011817 74 0
RARA MCF7GSE15244 152964921 152965113 192 0
RARA MCF7GSE15244 152968348 152969119 771 0
RARA MCF7GSE15244 153009842 153010356 514 0
RARA MCF7GSE15244 153013761 153014951 1190 0
RARG MCF7GSE15244 152968348 152969684 1336 0
RNAII Tamoxifen-MCF7GSE14664 152942638 152942682 44 0
Sox2 hESGSE18292 152955330 152955554 224 0
TAF k562GSE8489 153014262 153015431 1169 0
hScc1 BcellGSE12603 152957509 152957935 426 0
hScc1 BcellGSE12603 152969281 152969792 511 0
hScc1 BcellGSE12603 152983662 152984030 368 0
hScc1 CdLSGSE12603 152969619 152970075 456 0
hScc1 CdLSGSE12603 153015611 153016645 1034 0
hScc1 G2GSE9613 152942104 152942399 295 0
hScc1 G2GSE9613 152945633 152945987 354 0
hScc1 G2GSE9613 152949196 152949470 274 0
hScc1 G2GSE9613 152954823 152954974 151 0
hScc1 G2GSE9613 152956239 152956425 186 0
hScc1 G2GSE9613 152994948 152995164 216 0
hScc1 G2GSE9613 153015813 153016605 792 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7c hsa-let-7c 21 19897480
hsa-let-7c hsa-let-7c 21 19897480
hsa-let-7c* hsa-let-7c 21 19897480
hsa-let-7c* hsa-let-7c 21 19897480
hsa-miR-1 hsa-mir-1-2 18 14697198
hsa-miR-1 hsa-mir-1-1 20 14697198
hsa-miR-1 hsa-mir-1-2 18 14697198
hsa-miR-1 hsa-mir-1-1 20 14697198
hsa-miR-101 hsa-mir-101-1 1 14697198
hsa-miR-101 hsa-mir-101-2 9 14697198
hsa-miR-101 hsa-mir-101-1 1 14697198
hsa-miR-101 hsa-mir-101-2 9 14697198
hsa-miR-122 hsa-mir-122 18 19296470
hsa-miR-122 hsa-mir-122 18 19296470
hsa-miR-122* hsa-mir-122 18 19296470
hsa-miR-122* hsa-mir-122 18 19296470
hsa-miR-125a-3p hsa-mir-125a 19 16331254
hsa-miR-125a-3p hsa-mir-125a 19 16331254
hsa-miR-125a-5p hsa-mir-125a 19 16331254
hsa-miR-125a-5p hsa-mir-125a 19 16331254
hsa-miR-125b hsa-mir-125b-1 11 19897480
hsa-miR-125b hsa-mir-125b-2 21 19897480
hsa-miR-125b hsa-mir-125b-1 11 19897480
hsa-miR-125b hsa-mir-125b-2 21 19897480
hsa-miR-125b-2* hsa-mir-125b-2 21 19897480
hsa-miR-125b-2* hsa-mir-125b-2 21 19897480
hsa-miR-130a hsa-mir-130a 11 20716963
hsa-miR-130a hsa-mir-130a 11 14697198
hsa-miR-130a hsa-mir-130a 11 20716963
hsa-miR-130a hsa-mir-130a 11 14697198
hsa-miR-130a* hsa-mir-130a 11 20716963
hsa-miR-130a* hsa-mir-130a 11 14697198
hsa-miR-130a* hsa-mir-130a 11 20716963
hsa-miR-130a* hsa-mir-130a 11 14697198
hsa-miR-130b hsa-mir-130b 22 20716963
hsa-miR-130b hsa-mir-130b 22 17573714
hsa-miR-130b hsa-mir-130b 22 20716963
hsa-miR-130b hsa-mir-130b 22 17573714
hsa-miR-130b* hsa-mir-130b 22 20716963
hsa-miR-130b* hsa-mir-130b 22 17573714
hsa-miR-130b* hsa-mir-130b 22 20716963
hsa-miR-130b* hsa-mir-130b 22 17573714
hsa-miR-132 hsa-mir-132 17 21124738
hsa-miR-132 hsa-mir-132 17 21118894
hsa-miR-132 hsa-mir-132 17 20010955
hsa-miR-132 hsa-mir-132 17 19843474
hsa-miR-132 hsa-mir-132 17 17994015
hsa-miR-132 hsa-mir-132 17 21124738
hsa-miR-132 hsa-mir-132 17 21118894
hsa-miR-132 hsa-mir-132 17 20010955
hsa-miR-132 hsa-mir-132 17 19843474
hsa-miR-132 hsa-mir-132 17 17994015
hsa-miR-132* hsa-mir-132 17 21124738
hsa-miR-132* hsa-mir-132 17 21118894
hsa-miR-132* hsa-mir-132 17 20010955
hsa-miR-132* hsa-mir-132 17 19843474
hsa-miR-132* hsa-mir-132 17 17994015
hsa-miR-132* hsa-mir-132 17 21124738
hsa-miR-132* hsa-mir-132 17 21118894
hsa-miR-132* hsa-mir-132 17 20010955
hsa-miR-132* hsa-mir-132 17 19843474
hsa-miR-132* hsa-mir-132 17 17994015
hsa-miR-137 hsa-mir-137 1 20368621
hsa-miR-137 hsa-mir-137 1 20368621
hsa-miR-146a hsa-mir-146a 5 20716963
hsa-miR-146a hsa-mir-146a 5 20716963
hsa-miR-146a* hsa-mir-146a 5 20716963
hsa-miR-146a* hsa-mir-146a 5 20716963
hsa-miR-146b-3p hsa-mir-146b 10 20716963
hsa-miR-146b-3p hsa-mir-146b 10 20716963
hsa-miR-146b-5p hsa-mir-146b 10 20716963
hsa-miR-146b-5p hsa-mir-146b 10 20716963
hsa-miR-155 hsa-mir-155 21 19897480
hsa-miR-155 hsa-mir-155 21 19897480
hsa-miR-155* hsa-mir-155 21 19897480
hsa-miR-155* hsa-mir-155 21 19897480
hsa-miR-181a hsa-mir-181a-2 9 19811318
hsa-miR-181a hsa-mir-181a-1 1 19811318
hsa-miR-181a hsa-mir-181a-2 9 19811318
hsa-miR-181a hsa-mir-181a-1 1 19811318
hsa-miR-181a* hsa-mir-181a-1 1 19811318
hsa-miR-181a* hsa-mir-181a-1 1 19811318
hsa-miR-181a-2* hsa-mir-181a-2 9 19811318
hsa-miR-181a-2* hsa-mir-181a-2 9 19811318
hsa-miR-181b hsa-mir-181b-1 1 19811318
hsa-miR-181b hsa-mir-181b-2 9 19811318
hsa-miR-181b hsa-mir-181b-1 1 19811318
hsa-miR-181b hsa-mir-181b-2 9 19811318
hsa-miR-181c hsa-mir-181c 19 19811318
hsa-miR-181c hsa-mir-181c 19 19811318
hsa-miR-181c* hsa-mir-181c 19 19811318
hsa-miR-181c* hsa-mir-181c 19 19811318
hsa-miR-181d hsa-mir-181d 19 19811318
hsa-miR-181d hsa-mir-181d 19 19811318
hsa-miR-184 hsa-mir-184 15 18203756
hsa-miR-184 hsa-mir-184 15 18203756
hsa-miR-186 hsa-mir-186 1 19811318
hsa-miR-186 hsa-mir-186 1 19811318
hsa-miR-186* hsa-mir-186 1 19811318
hsa-miR-186* hsa-mir-186 1 19811318
hsa-miR-194 hsa-mir-194-1 1 17347136
hsa-miR-194 hsa-mir-194-2 11 17347136
hsa-miR-194 hsa-mir-194-1 1 17347136
hsa-miR-194 hsa-mir-194-2 11 17347136
hsa-miR-195 hsa-mir-195 17 16331254
hsa-miR-195 hsa-mir-195 17 16331254
hsa-miR-195* hsa-mir-195 17 16331254
hsa-miR-195* hsa-mir-195 17 16331254
hsa-miR-199b-3p hsa-mir-199b 9 20716963
hsa-miR-199b-3p hsa-mir-199b 9 20716963
hsa-miR-199b-5p hsa-mir-199b 9 20716963
hsa-miR-199b-5p hsa-mir-199b 9 20716963
hsa-miR-19a hsa-mir-19a 13 14697198
hsa-miR-19a hsa-mir-19a 13 14697198
hsa-miR-19a* hsa-mir-19a 13 14697198
hsa-miR-19a* hsa-mir-19a 13 14697198
hsa-miR-200a hsa-mir-200a 1 16331254
hsa-miR-200a hsa-mir-200a 1 16331254
hsa-miR-200a* hsa-mir-200a 1 16331254
hsa-miR-200a* hsa-mir-200a 1 16331254
hsa-miR-212 hsa-mir-212 17 20711185
hsa-miR-212 hsa-mir-212 17 20711185
hsa-miR-221 hsa-mir-221 X 20716963
hsa-miR-221 hsa-mir-221 X 20716963
hsa-miR-221* hsa-mir-221 X 20716963
hsa-miR-221* hsa-mir-221 X 20716963
hsa-miR-224 hsa-mir-224 X 16331254
hsa-miR-224 hsa-mir-224 X 16331254
hsa-miR-23a hsa-mir-23a 19 14697198
hsa-miR-23a hsa-mir-23a 19 14697198
hsa-miR-23a* hsa-mir-23a 19 14697198
hsa-miR-23a* hsa-mir-23a 19 14697198
hsa-miR-23b hsa-mir-23b 9 14697198
hsa-miR-23b hsa-mir-23b 9 14697198
hsa-miR-23b* hsa-mir-23b 9 14697198
hsa-miR-23b* hsa-mir-23b 9 14697198
hsa-miR-26a hsa-mir-26a-1 3 14697198
hsa-miR-26a hsa-mir-26a-2 12 14697198
hsa-miR-26a hsa-mir-26a-1 3 14697198
hsa-miR-26a hsa-mir-26a-2 12 14697198
hsa-miR-296-3p hsa-mir-296 20 20716963
hsa-miR-296-3p hsa-mir-296 20 20716963
hsa-miR-296-5p hsa-mir-296 20 20716963
hsa-miR-296-5p hsa-mir-296 20 20716963
hsa-miR-29b hsa-mir-29b-1 7 20716963
hsa-miR-29b hsa-mir-29b-2 1 20716963
hsa-miR-29b hsa-mir-29b-1 7 20716963
hsa-miR-29b hsa-mir-29b-2 1 20716963
hsa-miR-302a hsa-mir-302a 4 20870751
hsa-miR-302a hsa-mir-302a 4 20870751
hsa-miR-302a* hsa-mir-302a 4 20870751
hsa-miR-302a* hsa-mir-302a 4 20870751
hsa-miR-302b hsa-mir-302b 4 20870751
hsa-miR-302b hsa-mir-302b 4 20870751
hsa-miR-302b* hsa-mir-302b 4 20870751
hsa-miR-302b* hsa-mir-302b 4 20870751
hsa-miR-302c hsa-mir-302c 4 20870751
hsa-miR-302c hsa-mir-302c 4 20870751
hsa-miR-302c* hsa-mir-302c 4 20870751
hsa-miR-302c* hsa-mir-302c 4 20870751
hsa-miR-302d hsa-mir-302d 4 20870751
hsa-miR-302d hsa-mir-302d 4 20870751
hsa-miR-302d* hsa-mir-302d 4 20870751
hsa-miR-302d* hsa-mir-302d 4 20870751
hsa-miR-302f hsa-mir-302f 0 20870751
hsa-miR-302f hsa-mir-302f 0 20870751
hsa-miR-329 hsa-mir-329-1 14 20716963
hsa-miR-329 hsa-mir-329-2 14 20716963
hsa-miR-329 hsa-mir-329-1 14 20716963
hsa-miR-329 hsa-mir-329-2 14 20716963
hsa-miR-342-3p hsa-mir-342 14 20716963
hsa-miR-342-3p hsa-mir-342 14 20716963
hsa-miR-342-5p hsa-mir-342 14 20716963
hsa-miR-342-5p hsa-mir-342 14 20716963
hsa-miR-34a hsa-mir-34a 1 14697198
hsa-miR-34a hsa-mir-34a 1 14697198
hsa-miR-34a* hsa-mir-34a 1 14697198
hsa-miR-34a* hsa-mir-34a 1 14697198
hsa-miR-373 hsa-mir-373 19 21086164
hsa-miR-373 hsa-mir-373 19 21086164
hsa-miR-373* hsa-mir-373 19 21086164
hsa-miR-373* hsa-mir-373 19 21086164
hsa-miR-382 hsa-mir-382 14 20716963
hsa-miR-382 hsa-mir-382 14 20716963
hsa-miR-409-3p hsa-mir-409 14 20716963
hsa-miR-409-3p hsa-mir-409 14 20716963
hsa-miR-409-5p hsa-mir-409 14 20716963
hsa-miR-409-5p hsa-mir-409 14 20716963
hsa-miR-590-3p hsa-mir-590 7 19811318
hsa-miR-590-3p hsa-mir-590 7 19811318
hsa-miR-802 hsa-mir-802 21 19897480
hsa-miR-802 hsa-mir-802 21 19897480
hsa-miR-99a hsa-mir-99a 21 19897480
hsa-miR-99a hsa-mir-99a 21 19897480
hsa-miR-99a* hsa-mir-99a 21 19897480
hsa-miR-99a* hsa-mir-99a 21 19897480
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
506 Unknown FALSE miR-19a MECP2 in vitro reporter gene assay (Luciferase) 14697198
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000169057 n_a n_a n_a n_a n_a
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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